The Atelier: a fundamental method of the architectural education

In times of instability in Portugal and almost in the entire world, due to a shortage of resources and a decrease in population, in a context in which construction and demolition are being responsible for a huge amount of garbage and waste, the great challenges facing architecture are centered on interrogating the territories, their history, memory and identity. Today’s context is made of moments of enormous doubts and changes followed by a hyper-specialization of knowledge. The deeper we look and search into, the more we become focused on particularities, isolating unconsciously from the complexity of context phenomena.info:eu-repo/semantics/publishedVersio

Experiencing spaces – a different approache of the architectural space

In today's society, where visualization predominate, there is little spatial experiences that can stimulate the entire repertoire of human senses. Architecture is the only art that is capable of producing inhabited spaces and provides spatial boundaries in which we, as human beings, can experiencespace. By virtue of this, the most of the experiences on a space can be reduced to a single sensory experience, the visual one.info:eu-repo/semantics/publishedVersio

Preventing weight gain in African American breast cancer survivors using smart scales and activity trackers: a randomized controlled pilot study

This study evaluated the feasibility and preliminary efficacy of two 6-month, self-regulation interventions that focused on daily self-weighing (DSW), and used objective monitoring and tailored feedback about weight (±activity), to prevent weight gain among African American breast cancer survivors

Precision of readout at the hunchback gene: analyzing short transcription time traces in living fly embryos

The simultaneous expression of the hunchback gene in the numerous nuclei of the developing fly embryo gives us a unique opportunity to study how transcription is regulated in living organisms. A recently developed MS2-MCP technique for imaging nascent messenger RNA in living Drosophila embryos allows us to quantify the dynamics of the developmental transcription process. The initial measurement of the morphogens by the hunchback promoter takes place during very short cell cycles, not only giving each nucleus little time for a precise readout, but also resulting in short time traces of transcription. Additionally, the relationship between the measured signal and the promoter state depends on the molecular design of the reporting probe. We develop an analysis approach based on tailor made autocorrelation functions that overcomes the short trace problems and quantifies the dynamics of transcription initiation. Based on live imaging data, we identify signatures of bursty transcription initiation from the hunchback promoter. We show that the precision of the expression of the hunchback gene to measure its position along the anterior-posterior axis is low both at the boundary and in the anterior even at cycle 13, suggesting additional post-transcriptional averaging mechanisms to provide the precision observed in fixed embryos

Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome.

Central fat distribution is increased in anovulatory women with polycystic ovary syndrome (PCOS) compared with ovulatory PCOS and matched controls. Among secreted adipocytokines, this is reflected mainly in lower levels of adiponectin

Classification of uterine anomalies by three-dimensional ultrasonography using ESHRE/ESGE criteria: inter-observer variability.

Objective: To evaluate the interobserver repeatability of the coronal view measurements and classification of the uterine malformations (UM) according to the ESHRE/ESGE consensus by transvaginal three-dimensional ultrasound (3D US). Methods: 89 transvaginal 3D volumes acquired during the last two years at Delta Ecografía in Madrid, Spain, were selected from our archive by convenience sampling. Two expert operators blinded from each other, performed post-hoc analysis using render mode and multiplanar-VCI navigation. Uterine wall thickness at the fundus, indentation of the cavity and indentation of the fundus were measured, classified and sub-classified following the recommendations of the ESHRE/ESGE consensus. The reproducibility of interobserver measurements and classification was examined by calculating intraclass correlation coefficients (ICC) and their 95% confidence intervals (CI) and kappa statistic (k).pre-print261 K

Modeling of the residue transport of lambda cyhalothrin, cypermethrin, malathion and endosulfan in three different environmental compartments in the Philippines

AbstractThis study aims to determine the environmental transport and fate of the residue of four Philippines priority chemicals; i.e., lambda cyhalothrin (L-cyhalothrin), cypermethrin, endosulfan and malathion, in three different environmental compartments (air, water and soil). In the Philippines, pesticide application is the most common method of controlling pests and weeds in rice and vegetable farming. This practice aided the agricultural industry to minimize losses and increase yield. However, indiscriminate use of pesticides resulted to adverse effects to public health and environment. Studies showed that 95% of the applied pesticides went to non-target species. Data from previous studies in Pagsanjan Laguna, Philippines were used as input data. Dispersion, Gaussian plume, and regression equations were employed to simulate the behavior of L-cyhalothrin, cypermethrin, endosulfan and malathion in air, water and soil. Substance decay was calculated using first order reaction. This study showed how L-cyhalothrin, cypermethrin, endosulfan, and malathion behaved in the environment after release from nozzle spray, and its possible duration of stay in the environment. It will also show a tool in determining the percolation depth through soil by endosulfan. This tool can be utilized in determining the depth of contaminated soil during remediation strategic planning and project implementation of similar environmental condition