Spes Nova II

Este PAP consistió en el seguimiento del proyecto iniciado en Otoño de 2022 en donde se siguió trabajando en colaboración con Spes Nova de la Universidad de Fordham para impulsar el comercio y desarrollo social de artesanos de la Zona Metropolitana de Guadalajara. Como continuación de este trabajo, los principales puntos que se abordaron fueron los siguientes: Se revisaron los aspectos legales, tanto documentos como económicos para la salida de artesanías de territorio nacional, se hizo un seguimiento con las dos partes, con el artesano en cuanto el pedido de muestras para elaboración de fichas técnicas y seguimiento de la producción de los productos, y hacia Spes Nova con el tema del seguimiento previo y para la solicitud de la orden del compra; para el apartado logístico se trabajó en la selección de los proveedores del servicio y coordinación con estos; en el tema financiero, se habló con ambas partes sobre que opciones de pago/cobro era más conveniente para cada uno y la selección del método adecuado; la realización de la documentación de todo el proceso realizado, a manera de guía, para que el artesano pueda continuar de manera autónoma. Por último todo este trabajo concluyó con el envío de las artesanías hacia Spes Nova.ITESO, A.C

Relationship of the Financial Audit Reports with the Going Concern Principle of the Manufacturing Companies in Dissolution and Liquidation of the City of Cuenca for the Period 2016 - 2021: Relación de los informes de Auditoría Financiera con el principio de Negocio en Marcha de las empresas manufactureras en disolución y liquidación de la ciudad de Cuenca del periodo 2016 – 2021

Varias empresas de manufactura de la ciudad de Cuenca han tratado de mantenerse en el mercado, que cada vez es más competitivo, pero una pequeña parte, ha tomado la decisión de disolver y liquidar su empresa debido a factores económicos. El objetivo de este estudio es determinar la relación existente entre el principio de Negocio en Marcha y las Auditorías financieras basándonos en la selección de una muestra, teniendo en cuenta criterios que causan la disolución y liquidación, dictados por el ente regulador. También se tomó en cuenta la presentación del último balance presentado del 2016 al 2021 de las empresas que se encuentren en situación legal de Disolución y Liquidación; tomando en cuenta solo empresas manufactureras que estén domiciliadas en la ciudad de Cuenca. Se aplicó un modelo predictivo de insolvencia el modelo Z-Score de Altman, mismo que fue aplicado a las 5 empresas seleccionadas para el estudio, compuesto por dos modelos, el primer Modelo Z1 que está estructurado para aplicarse específicamente a empresas manufactureras que no cotizan en bolsa de valores, y el Modelo Z2 que enfatiza en la generación de rendimientos sobre el activo y su reinversión, el cual puede ser aplicado a cualquier tipo de empresa. El resultado final muestra una relación entre el informe de Auditoría Externa y el principio de Negocio en Marcha de las empresas manufactureras de la ciudad de Cuenca de un 40%, mientras que la no relación entre el informe y el principio de negocio en marcha representa un 60%

South American Plasmodium falciparum after the Malaria Eradication Era: Clonal Population Expansion and Survival of the Fittest Hybrids

Malaria has reemerged in many regions where once it was nearly eliminated. Yet the source of these parasites, the process of repopulation, their population structure, and dynamics are ill defined. Peru was one of malaria eradication's successes, where Plasmodium falciparum was nearly eliminated for two decades. It reemerged in the 1990s. In the new era of malaria elimination, Peruvian P. falciparum is a model of malaria reinvasion. We investigated its population structure and drug resistance profiles. We hypothesized that only populations adapted to local ecological niches could expand and repopulate and originated as vestigial populations or recent introductions. We investigated the genetic structure (using microsatellites) and drug resistant genotypes of 220 parasites collected from patients immediately after peak epidemic expansion (1999–2000) from seven sites across the country. The majority of parasites could be grouped into five clonal lineages by networks and AMOVA. The distribution of clonal lineages and their drug sensitivity profiles suggested geographic structure. In 2001, artesunate combination therapy was introduced in Peru. We tested 62 parasites collected in 2006–2007 for changes in genetic structure. Clonal lineages had recombined under selection for the fittest parasites. Our findings illustrate that local adaptations in the post-eradication era have contributed to clonal lineage expansion. Within the shifting confluence of drug policy and malaria incidence, populations continue to evolve through genetic outcrossing influenced by antimalarial selection pressure. Understanding the population substructure of P. falciparum has implications for vaccine, drug, and epidemiologic studies, including monitoring malaria during and after the elimination phase

The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry

Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

COVID-19 Mortality in Patients Aged 80 and over Residing in Nursing Homes—Six Pandemic Waves: OCTA-COVID Study

During the first COVID-19 pandemic wave in Spain, 50% of deaths occurred in nursing homes, making it necessary for some hospitals to support these facilities with the care of infected patients. This study compares origin, characteristics, and mortality of patients admitted with COVID-19 during six pandemic waves in the Hospital Central de la Cruz Roja in Madrid. It is a retrospective observational study of patients ≥80 years old, admitted with an acute SARS-CoV-2 infection, with a total of 546 patients included, whose final outcome was death or discharge. During the first wave, those from nursing homes had a higher risk of death than those from home; during the two successive waves, the risk was higher for those from home; and in the last two waves, the risk equalized and decreased exponentially in both groups. Men had 72% higher risk of death than women. For each year of age, the risk increased by 4% (p = 0.036). For each Charlson index point, the risk increased by 14% (p = 0.019). Individuals in nursing homes, despite being older with higher comorbidity, did not show a higher overall lethality. The mortality decreased progressively in each successive wave due to high vaccination rates and COVID-19 control measures in this population

ASISTENCIA A PADRES DE EMBARAZOS CON RECIEN NACIDOS CON PROBLEMAS VITALES

El Consultorio de Asistencia Perinatal atiende a padres de embarazos con fetos en riesgo vital, malformados complejos y nacidos con problemas graves que impliquen impacto familiar, basados en la hipótesis de que la atención de los padres incide en el bienestar del feto y del recién nacido. Se ha construido un protocolo multiprofesional con participación de pediatra, psicóloga, matronas, obstetra y servicio social que sigue el caso con reuniones grupales y de especialidad desde antes del parto hasta después del desenlace, cualquiera sea éste. Este trabajo a permitido conocer, asistir e investigar sobre la realidad de estos padres que requieren de apoyo especializado para sobrellevar los sentimientos de duelo, temor y culpa que se desarrollan en estas situaciones, derivar a otros tratamientos psiquiátricos cuando es necesario y preparar a los padres ante la eventualidad de nuevos embarazo

The other stone. Dacite quarries and workshops in the prehispanic Tarascan territory, Michoacán, Mexico

International audience"Due to its sheer abundance and informative potential, Mesoamerican archaeology tends to focus on obsidian as a mineral resource. As a result, other volcanic rocks such as basalt, andesite, or dacite have received much less attention. In the highlands of Mesoamerica, knapped tools from the latter raw materials are generally perceived to stem from local resources from which they were procured by simple surface collection. The extensive dacite quarry-workshops of Las Lajitas and La Tronconera in Northern Michoacán represent thus an unprecedented discovery. In this paper, we examine from the quarry-workshop perspective how dacite was a crucial resource for the economy of pre-Tarascan and Tarascan societies from the Early Classic period to the Postclassic period (350–1450 CE). Dacite was central to an integrated production system for the large-scale manufacture of normalized knapped tools, which operated in the same way as at major obsidian deposits in Mesoamerica. The fieldwork with methodical Global Positioning System (GPS) and total station surveying brought to light numerous zones of lithic waste accumulation, some of which extend over several hectares. They are located on a lava flow identified as dacitic from a petrographic and chemical viewpoint. Topographic depressions correspond to open extraction pits alongside areas reserved for debitage. The techno-morphological characteristics of the lithic sample gathered in test units shows that production was mainly geared towards the normalized manufacture of large dome-shaped scraper-plane preforms, which were traded within the entire region." (source éditeur