Trichomonas Transmembrane Cyclases Result from Massive Gene Duplication and Concomitant Development of Pseudogenes

Trichomonas vaginalis is the only medically important protist (single-cell eukaryote) that is sexually transmitted. The ∼160-Mb Trichomonas genome contains more predicted protein-encoding genes (∼60,000) than the human genome. To begin to understand why there are so many copies of some genes, we chose here to study a large family of genes encoding unique transmembrane cyclases. Our most important results include the following. More than 100 transmembrane cyclase genes do not result from chromosomal duplications, because for the most part only the coding regions of the genes, rather than flanking sequences, are duplicated. Almost half of the transmembrane cyclase genes are pseudogenes, and these pseudogenes are polymorphic among laboratory strains of Trichomonas. Messenger RNAs for numerous transmembrane cyclases are expressed simultaneously, and representative cyclase domains have adenylyl cyclase activity. In summary, the large family of Trichomonas genes encoding transmembrane adenylyl cyclases results from massive gene duplication and concomitant development of pseudogenes

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Transition Services For Youth With Autism: A Systematic Review

Purpose: As the number of individuals diagnosed with autism spectrum disorders (ASDs) rises, attention is increasingly focused on employment outcomes for individuals with ASD who are exiting public school settings. This review aimed to identify what works in transition programs to help students with ASD obtain competitive employment after graduation. Method: Authors combed through the literature to find all research that could definitively identify interventions that predictably led to employment for transitioning youth. Results: While no definitive conclusions can be drawn based upon the current review, the authors identified qualitative research that addressed elements of potential successful employment placements for individuals with ASD. Discussion: Future research efforts are needed to develop studies that utilize rigorous experimental designs to determine the relative effectiveness of the various interventions being utilized in transition programming for students with ASD. This review is published in its entirety in the Campbell Collaboration Library of Systematic Reviews

Declines in efficacy of anti-bullying programs among older adolescents: Theory and a three-level meta-analysis

10.1016/j.appdev.2014.11.005JOURNAL OF APPLIED DEVELOPMENTAL PSYCHOLOGY37136-5

The Increasing Trend of Inferring Causality from Correlation in Educational Psychology Journals

The field of educational psychology has been moving away from intervention and experimental methods and toward observational and correlational methods (Hsieh et al., 2005; Reinhart et al., 2013; Robinson et al., 2007). Additionally, there has been an increase in the percentage of observational/correlational articles that include recommendations for practice. The present study updated previous data to 2020 by examining methodologies and recommendations for practice in articles published in five empirical educational psychology journals (Journal of Educational Psychology, American Educational Research Journal, Cognition and Instruction, Journal of Experimental Education, and Contemporary Educational Psychology). The percentage of articles employing experimental methods has continued to decrease (20%), whereas qualitative methods have increased (22%). Across correlational, qualitative, and mixed-methods articles, two-thirds included recommendations for practice – up from 46% in 2010. Implications are discussed

Individual and Institutional Productivity in Educational Psychology Journals from 2015 to 2021

This study updates and extends prior work on institutional and individual productivity in educational psychology journals (Cognition and Instruction, Contemporary Educational Psychology, Educational Psychologist, Educational Psychology Review, Journal of Educational Psychology) from 2015 to 2021. As in previous studies, the University of Maryland, College Park, was the top-producing institution. Several universities (e.g., University of Tübingen) emerged as highly productive compared to previous time periods. Using two approaches to measure individual productivity, we found that Richard Mayer, Ulrich Trautwein, Fred Paas, Patricia Alexander, and Logan Fiorella claimed the top spots. We also identified productive early career scholars and, for some, recognized connections to productive doctoral advisors. Overall, compared to prior years, authors of educational psychology journal articles were increasingly working from non-US institutions and in larger teams (higher mean number of authors per article). A discussion of these trends and future directions for research are included