General Time-Dependent Configuration-Interaction Singles II: The Atomic Case

We present a specialization of the grid-based implementation of the time-dependent configuration-interaction singles described in the preceding paper [S. Carlström et al., preceding paper, Phys. Rev. A 106, 043104 (2022)]. to the case of spherical symmetry. We describe the intricate time propagator in detail and conclude with a few example calculations. Among these, of note are high-resolution photoelectron spectra in the vicinity of the Fano resonances in photoionization of neon and spin-polarized photoelectrons from xenon, in agreement with recent experiments

Thomas--Reiche--Kuhn Correction for Truncated Configuration Interaction Spaces: Case of Laser-Assisted Dynamical Interference

The Thomas--Reiche--Kuhn sum rule is used to form an effective potential that is added to the time-dependent configuration interaction singles (TDCIS) equations of motion in velocity gauge. The purpose of the effective potential is to include virtual coupling from singles to doubles, which is required for size-consistent velocity gauge TDCIS results. The proposed method is compared to length gauge TDCIS results for laser-assisted photoionization. Finally, a novel dynamical interference effect controlled by two-color fields is predicted for atomic targets

Development of Salt-Sensitive Hypertension in Hydronephrosis

Hydronephrosis, due to ureteropelvic junction obstruction, is a common condition in infants with an incidence of approximately 0.5-1%. During the last decade, the surgical management of non-symptomatic hydronephrosis has become more conservative, and the long-term physiological consequences of this new policy are unclear. The overall aim of this thesis was to determine whether there is a link between hydronephrosis and the development of hypertension. Hydronephrosis was induced by partial ureteral obstruction in 3-week old rats or mice. In the adult animals, blood pressure was measured telemetrically during different sodium conditions and the renal function was evaluated. Both species developed salt-sensitive hypertension and histopathological changes (i.e. fibrosis, inflammation, glomerular and tubular changes) that correlated with the degree of hydronephrosis. An abnormal renal excretion pattern with increased diuresis and impaired urine concentrating ability was observed in hydronephrosis. The mechanisms were primarily located to the diseased kidney, as relief of the obstruction attenuated blood pressure and salt-sensitivity. Increased renin angiotensin system activity, due to ureteral obstruction, might be involved in the development but not necessary the maintenance of hypertension. Hydronephrotic animals displayed reduced nitric oxide availability, which might be due to increased oxidative stress in the diseased kidney. Renal nitric oxide deficiency and subsequent resetting of the tubuloglomerular feedback mechanism, appeared to have an important role in the development of hypertension. In conclusion, experimental hydronephrosis, induced by partial ureteral obstruction, provides a new model for studies of salt-sensitive hypertension. Furthermore, the new findings imply that the current conservative treatment strategy in hydronephrosis should be reconsidered in favour of treatment that is more active, in order to prevent the development of renal injury and hypertension in later life

Närståendes erfarenheter av intensivsjukvård i Norden : En litteraturstudie

Bakgrund: Synen på närståendes betydelse för den sjukes välmående har radikalt förändras under de senaste århundraden, till en allt mer holistisk syn på den sjuke och dennes behov. Patienter vårdandes på en intensivvårdsavdelning riskerar eller är försatta i ett livshotande tillstånd där specialiserad vård krävs. Det är därför av vikt att veta hur närstående upplever en intensivvårdsavdelning för att kunna erbjuda både den sjuke och dess närstående bästa möjliga vård. Syftet är att beskriva erfarenheter av att vara närstående till en person som vårdats på en intensivvårdsavdelning i Norden. Metoden som användes är en systematisk litteraturstudie av vetenskapliga artiklar, som inhämtades via sökningar i Cinahl, PubMed och PsycINFO. Artiklarna kvalitetsgranskades och resultaten analyserades med kvalitativ innehållsanalys. Resultatet visar att närstående upplever en kaotisk tillvaro i och med deras anhörigas insjuknande. De uttrycker behov av att få information både angående den sjukes medicinska status, men även om den medicintekniska miljön patienten omges av. Närstående erfar även att sjuksköterskans agerande är avgörande för om de själva involverar sig i omvårdnaden av den sjuke, och uttrycker ett behov av att få stöd och tröst från sjuksköterskan. Kommunikationen mellan närstående och sjuksköterskan är stundtals bristfällig, vilket närstående upplevde som svårt. Slutsatsen av studien är att närstående behöver stöd från sjuksköterskan för att kunna minska stress och kunna skapa balans i tillvaron. Korrekt och kontinuerlig information samt att sjuksköterskan säkerställer att närstående uppfattar informationen korrekt kan hjälpa närstående att hantera situationen. Nyckelord: Kritiskt sjuk, Intensivsjukvård, Närstående, Närståendes erfarenheter, besökare till patiente

Närståendes erfarenheter av intensivsjukvård i Norden : En litteraturstudie

Bakgrund: Synen på närståendes betydelse för den sjukes välmående har radikalt förändras under de senaste århundraden, till en allt mer holistisk syn på den sjuke och dennes behov. Patienter vårdandes på en intensivvårdsavdelning riskerar eller är försatta i ett livshotande tillstånd där specialiserad vård krävs. Det är därför av vikt att veta hur närstående upplever en intensivvårdsavdelning för att kunna erbjuda både den sjuke och dess närstående bästa möjliga vård. Syftet är att beskriva erfarenheter av att vara närstående till en person som vårdats på en intensivvårdsavdelning i Norden. Metoden som användes är en systematisk litteraturstudie av vetenskapliga artiklar, som inhämtades via sökningar i Cinahl, PubMed och PsycINFO. Artiklarna kvalitetsgranskades och resultaten analyserades med kvalitativ innehållsanalys. Resultatet visar att närstående upplever en kaotisk tillvaro i och med deras anhörigas insjuknande. De uttrycker behov av att få information både angående den sjukes medicinska status, men även om den medicintekniska miljön patienten omges av. Närstående erfar även att sjuksköterskans agerande är avgörande för om de själva involverar sig i omvårdnaden av den sjuke, och uttrycker ett behov av att få stöd och tröst från sjuksköterskan. Kommunikationen mellan närstående och sjuksköterskan är stundtals bristfällig, vilket närstående upplevde som svårt. Slutsatsen av studien är att närstående behöver stöd från sjuksköterskan för att kunna minska stress och kunna skapa balans i tillvaron. Korrekt och kontinuerlig information samt att sjuksköterskan säkerställer att närstående uppfattar informationen korrekt kan hjälpa närstående att hantera situationen. Nyckelord: Kritiskt sjuk, Intensivsjukvård, Närstående, Närståendes erfarenheter, besökare till patiente

Legacy system : organisationers användning av systemförvaltning för att hantera legacy systemproblem

Validerat; 20101217 (root

Effect of nitric oxide on renal autoregulation during hypothermia in the rat.

Hypothermia-induced reduction of metabolic rate is accompanied by depression of both glomerular perfusion and filtration. The present study investigated whether these changes are linked to changes in renal autoregulation and nitric oxide (NO) signalling. During hypothermia, renal blood flow (RBF) and glomerular filtration rate (GFR) were reduced and urine production was increased, and this was linked with reduced plasma cGMP levels and increased renal vascular resistance. Although stimulation of NO production decreased vascular resistance, blood pressure and urine flow, intravenous infusion of the NO precursor L-arginine or the NO donor sodium nitroprusside did not alter RBF or GFR. In contrast, inhibition of NO synthesis by N(w)-nitro-L-arginine led to a further decline in both parameters. Functional renal autoregulation was apparent at both temperatures. Below the autoregulatory range, RBF in both cases increased in proportion to the perfusion ±pressure, although, the slope of the first ascending limb of the pressure-flow relationship was lower during hypothermia. The main difference was rather that the curves obtained during hypothermia levelled off already at a RBF of 3.9 ± 0.3 mL/min then remained stable throughout the autoregulatory pressure range, compared to 7.6 ± 0.3 mL/min during normothermia. This was found to be due to a threefold increase in, primarily, the afferent arteriolar resistance from 2.6 to 7.5 mmHg min mL(-1). Infusion of sodium nitroprusside did not significantly affect RBF during hypothermia, although a small increase at pressures below the autoregulatory range was observed. In conclusion, cold-induced rise in renal vascular resistance results from afferent arteriolar vasoconstriction by the autoregulatory mechanism, setting RBF and GFR in proportion to the metabolic rate, which cannot be explained by reduced NO production alone

General time-dependent configuration-interaction singles. II. Atomic case

We present a specialization of the grid-based implementation of the time-dependent configuration-interaction singles described in the preceding paper [S. Carlström et al., preceding paper, Phys. Rev. A 106, 043104 (2022)]10.1103/PhysRevA.106.043104. to the case of spherical symmetry. We describe the intricate time propagator in detail and conclude with a few example calculations. Among these, of note are high-resolution photoelectron spectra in the vicinity of the Fano resonances in photoionization of neon and spin-polarized photoelectrons from xenon, in agreement with recent experiments

Dose-Dependent Effects of Long-Term Administration of Hydrogen Sulfide on Myocardial Ischemia–Reperfusion Injury in Male Wistar Rats: Modulation of RKIP, NF-κB, and Oxidative Stress

Decreased circulating levels of hydrogen sulfide (H2S) are associated with higher mortality following myocardial ischemia. This study aimed at determining the long-term dose-dependent effects of sodium hydrosulfide (NaSH) administration on myocardial ischemia-reperfusion (IR) injury. Male rats were divided into control and NaSH groups that were treated for 9 weeks with daily intraperitoneal injections of normal saline or NaSH (0.28, 0.56, 1.6, 2.8, and 5.6 mg/kg), respectively. At the end of the study, hearts from all rats were isolated and hemodynamic parameters were recorded during baseline and following IR. In isolated hearts, infarct size, oxidative stress indices as well as mRNA expression of H2S-, nitric oxide (NO)-producing enzymes, and inflammatory markers were measured. In heart tissue following IR, low doses of NaSH (0.28 and 0.56 mg/kg) had no effect, whereas an intermediate dose (1.6 mg/kg), improved recovery of hemodynamic parameters, decreased infarct size, and decreased oxidative stress. It also increased expression of cystathionine γ-lyase (CSE), Raf kinase inhibitor protein (RKIP), endothelial NO synthase (eNOS), and neuronal NOS (nNOS), as well as decreased expression of inducible NOS (iNOS) and nuclear factor kappa-B (NF-κB). At the high dose of 5.6 mg/kg, NaSH administration was associated with worse recovery of hemodynamic parameters and increased infarct size as well as increased oxidative stress. This dose also decreased expression of CSE, RKIP, and eNOS and increased expression of iNOS and NF-κB. In conclusion, chronic treatment with NaSH has a U-shaped concentration effect on IR injury in heart tissue. An intermediate dose was associated with higher CSE-derived H2S, lower iNOS-derived NO, lower oxidative stress, and inflammation in heart tissue following IR