SPASMOLYTIC, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITY OF SALVIA GESNERIFLORA LINDLEY

Background: Salvia gesneriflora Lindley is employed in traditional Mexican medicine for the treatment of several diseases. Materials and Methods: The chromatographic profile of three extracts (SgH, SgD and SgM) of this plant allowed the identification of 11 components in SgH, the presence of rosmarinic (1), chlorogenic (2) and caffeic (3) acids and quercetin glucoside (4) in SgM and of ursolic acid (5) in SgD. The spasmolytic (electrically induced contractions of guinea-pig ileum), anti-inflammatory (edema in mouse ear) and antioxidant potential (DPPH, ABTS and FRAP assays) of the extracts were evaluated. Results: SgM showed the highest percentage of relaxation (80.67 ± 1.633%) with no significant difference (

Spasmolytic, anti-inflammatory, and antioxidant activities of Salvia gesneriflora Lindley

Background: Salvia gesneriflora Lindley is employed in traditional Mexican medicine for the treatment of several diseases. This work reports the spasmolytic, anti-inflammatory and antioxidant activities of salvia gesnerifloraMaterials and Methods: The chromatographic profile of three extracts (SgH, SgD and SgM) of this plant allowed the identification of 11 components in SgH, the presence of rosmarinic (1), chlorogenic (2) and caffeic (3) acids and quercetin glucoside (4) in SgM and of ursolic acid (5) in SgD. The spasmolytic (electrically-induced contractions of guinea-pig ileum), anti-inflammatory (edema in mouse ear) and antioxidant potential (DPPH, ABTS and FRAP assays) of the extracts were evaluated.Results: SgM showed the highest percentage of relaxation (80.67 ± 1.633%) with no significant difference (p<0.05) when compared to the reference drug employed (Papaverine, 76.16 ± 2.44%), the EC50 was 66.89 ± 1.6 μg/mL, respectively for SgH and 26.88 ± 1.9 μg/mL for Papaverine. Antiinflammatory activity was 71.12 ± 4.9% for SgH, an effect which is similar to that of Indomethacin (reference drug) at the same dose (75.24 ± 2.4%). In the DPPH test, SsM reached the least CI50 (1.16±1.08 μg/mL). For ABTS, SgH reached the least CI50 (1.73 ± 0.5 μg/mL) and for the FRAP assay, SgD showed the highest reductive capacity (1,782.08 ± 2.1 equivalent mM of FeSO4).Conclusion: S. gesneriflora extracts exhibited spasmolytic, anti-inflammatory and antioxidant activities; thus serving as co-adjuvants with regard to knowledge in the traditional medicine of this plant species and its application’s potential in other fields of pharmacy and foods.Keywords: Salvia gesneriflora Lindley, spasmolytic, spasmodic, anti-inflammatory, antioxidant activit

Inicio e Impulso de la Investigación en Química Orgánica en la DACB-UJAT

Documento del Xl Congreso Internacional Retos y Expectativas de la Universidad (2011

Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity

Haematoxylum campechianum is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (1); 3-deoxysappanchalcone (2); three homoisoflavonoids known as hematoxylol A (3); 4-O-methylhematoxylol (4); and, hematoxin (5). The spasmolytic activity was determined in an in vitro model (electrically induced contractions of guinea pig ileum), and allowed to demonstrate that the methanolic extract (EC50 = 62.11 ± 3.23) fractions HcF7 (EC50 = 61.75 ± 3.55) and HcF9 (EC50 = 125.5 ± 10.65) and compounds 1 (EC50 = 16.06 ± 2.15) and 2 (EC50 = 25.37 ± 3.47) of Haematoxylum campechianum present significant relaxing activity as compared to papaverine (EC50 = 20.08 ± 2.0) as a positive control

Revisión de la historia y aplicación de escuaramida en organocatálisis

Squaramide and its derivatives represent an important group of substances that are currently being successfully applied in asymmetric organocatalitic strategies, which is why this contribution presents a summary of the state of the art related to the synthesis of escuaramide derivatives and their role as chirality inducers in relevant synthetic sequences. To this end, a process of systematic search and selection of reports published in specialized journals of the area was established in order to present the most significant aspects of synthesis and the application of escuaramide derivatives in this key area of organic chemistry.La escuaramida y sus derivados representan un importante grupo de sustancias que actualmente se están aplicando exitosamente en estrategias de organocatálisis asimétrica. En esta contribución se presenta un resumen del estado del arte relativo a la síntesis de los derivados de escuaramida y su papel como inductores de quiralidad en secuencias sintéticas relevantes. Por ello, se establece un proceso de búsqueda sistemática y selección de reportes publicados en revistas especializadas del área, con la finalidad de presentar los aspectos más notables de síntesis y la aplicación de los derivados de escuaramida en esta sustancial área de la química orgánica

Ellagitannin, Phenols, and Flavonoids as Antibacterials from Acalypha arvensis (Euphorbiaceae)

There is a significant need to gain access to new and better antibacterial agents. Acalypha arvensis, a plant from the Euphorbiaceae family, has been used in traditional medicine for centuries to treat infectious diseases. This manuscript reports the isolation, characterization, and antibacterial screening of 8 natural products extracted from maceration of aerial parts of Acalypha arvensis. Specifically, three extracts were assessed (n-hexane, ethyl acetate, and ethanol), in which antibacterial activity was evaluated against diverse bacterial strains. The ethanolic extract showed the best activity against methicillin-sensitive and methicillin-resistant Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa strains, which supports the medicinal properties attributed to this plant. The chromatographic fractions AaR4 and AaR5 were the most bioactive, in which the ellagitannin natural product known as corilagin (1) was identified for the first time in this plant. Therefore, it can be said that this is the main chemical responsible for the observed antibacterial activity. However, we also identified chlorogenic acid (2), rutin (3), quercetin-3-O-glucoside (4), caffeic acid (5), among others (6–8). Hence, this plant can be considered to be a good alternative to treat health-related issues caused by various bacteria