Perfil del paciente canino con cuerpos extraños esofágicos

Objetivo. Determinar el perfil del paciente canino que presenta cuerpos extraños esofágicos para identificar las características de riesgo al presentar esta entidad. Materiales y métodos. Este es un estudio retrospectivo realizado en el Hospital Clínico Veterinario de la Universidad de Extremadura (HCV). Se analizaron diferentes parámetros de los perros que presentaron un diagnóstico endoscópico de cuerpos extraños esofágicos. Resultados. Esta patología se presentó más comúnmente en perros adultos jóvenes y en pacientes de raza pequeña. Se presenta por primera vez al Podenco Portugués, el cual además representó la raza con mayor factor de riesgo. Conclusiones. Los resultados obtenidos en esta investigación concuerdan con lo descrito anteriormente en cuanto a las características del paciente con cuerpo extraño esofágico. Asimismo, se reporta el Podenco Portugués como predispuesto a esta entidad, con un factor de riesgo mayor al de otras razas anteriormente mencionadas en la literatura. Para prevenir los cuerpos extraños esofágicos, se debe alimentar con carne cruda y huesos a los perros, especialmente a los de raza pequeña. Siempre se debe tener en cuenta esta patología en los perros con sintomatología de enfermedad esofágica sin importar su edad, pues su presentación es más común en perros adultos jóvenes.Objective. Determine the profile of the canine patient with esophageal foreign bodies to identify risk factors associated with the foreign bodies. Materials and Methods. This is a retrospective study made by the Veterinary Hospital Clinic of the Universidad de Extremadura (VHC). Different factors were analyzed in dogs with an endoscopic diagnosis of esophageal foreign bodies. Results. This pathology was more commonly found in young adult dogs and in small breeds. This pathology was present for the first time in the Portuguese Warren Hound, which was also the breed with the highest risk. Conclusions. The results obtained in this investigation are in agreement with the previous description of a patient that presents esophageal foreign bodies. Also, the Portuguese Warren Hound was found to be predisposed to this problem, with a higher risk factor than other breeds previously mentioned in the literature. To prevent esophageal foreign bodies, dogs should be fed raw meat and bones, especially small breeds. This pathology should always be kept in mind in dogs with esophagitis symptomology regardless of age, although it is most common in young adult dogs.peerReviewe

Perfil del paciente canino con cuerpos extraños esofágicos

Objetivo. Determinar el perfil del paciente canino que presenta cuerpos extraños esofágicos para identificar las características de riesgo al presentar esta entidad. Materiales y métodos. Este es un estudio retrospectivo realizado en el Hospital Clínico Veterinario de la Universidad de Extremadura (HCV). Se analizaron diferentes parámetros de los perros que presentaron un diagnóstico endoscópico de cuerpos extraños esofágicos. Resultados. Esta patología se presentó más comúnmente en perros adultos jóvenes y en pacientes de raza pequeña. Se presenta por primera vez al Podenco Portugués, el cual además representó la raza con mayor factor de riesgo. Conclusiones. Los resultados obtenidos en esta investigación concuerdan con lo descrito anteriormente en cuanto a las características del paciente con cuerpo extraño esofágico. Asimismo, se reporta el Podenco Portugués como predispuesto a esta entidad, con un factor de riesgo mayor al de otras razas anteriormente mencionadas en la literatura. Para prevenir los cuerpos extraños esofágicos, se debe alimentar con carne cruda y huesos a los perros, especialmente a los de raza pequeña. Siempre se debe tener en cuenta esta patología en los perros con sintomatología de enfermedad esofágica sin importar su edad, pues su presentación es más común en perros adultos jóvenes.Objective. Determine the profile of the canine patient with esophageal foreign bodies to identify risk factors associated with the foreign bodies. Materials and Methods. This is a retrospective study made by the Veterinary Hospital Clinic of the Universidad de Extremadura (VHC). Different factors were analyzed in dogs with an endoscopic diagnosis of esophageal foreign bodies. Results. This pathology was more commonly found in young adult dogs and in small breeds. This pathology was present for the first time in the Portuguese Warren Hound, which was also the breed with the highest risk. Conclusions. The results obtained in this investigation are in agreement with the previous description of a patient that presents esophageal foreign bodies. Also, the Portuguese Warren Hound was found to be predisposed to this problem, with a higher risk factor than other breeds previously mentioned in the literature. To prevent esophageal foreign bodies, dogs should be fed raw meat and bones, especially small breeds. This pathology should always be kept in mind in dogs with esophagitis symptomology regardless of age, although it is most common in young adult dogs.peerReviewe

Upper Miocene deposits at the southern margin of the Guadalquivir Foreland Basin (central Betic Cordillera, S. Spain). Implications for the closure timing of the Atlantic-Mediterranean connections

Acknowledgments We acknowledge the comments and suggestions made by two re- viewers, which have improved the quality of the paper. We thank Jodi Eckart for her help correcting the English text. Dr Sánchez-Almazo helped with the SEM analyses and photographs of foraminifers. This paper has been supported by the research project PGC2018–099391-B- 100 of the Spanish Ministerio de Ciencia, Innovación y Competitividad, and the research group RMN190 of the Junta de Andalucía.Mixed siliciclastic-carbonate deposits accumulated in several satellite sub-basins at the southern margin of the Guadalquivir Basin, the foreland basin of the Betic Cordillera (S. Spain). The prevailing coarse-grained sediments and deposition in shallow-water settings make it difficult to establish the precise age of the complete successions. For this reason, in previous studies, these deposits were attributed to the late Tortonian, although a Messinian age was not totally ruled out. The age of the upper Miocene deposits in the central part of the Guadalquivir Basin is here re-evaluated based on the analysis of several sections distributed in different areas: Antequera, Iznájar-Cuevas de San Marcos, Teba, and Bobadilla Estación. According to planktonic foraminifer and nannoplankton assemblages, the marine sedimentary infill of this sector of the southern margin of the Guadalquivir Basin is late Tortonian-early Messinian (late Miocene) in age. The occurrence of marine deposits characterized by the dominance of Globorotalia miotumida group, dextrally-coiled G. scitula, and the presence of G. margaritae, Globigerina multiloba, Discoaster quinqueramus, Amaurolithus primus, A. amplificus, and Reticulofenestra rotaria at the northern end of the Guadalhorce Corridor, the last active gateway in the Betic Cordillera connecting the Atlantic and the Mediterranean, indicates that it remained open until the early Messinian.Research project PGC2018–099391-B- 100 of the Spanish Ministerio de Ciencia, Innovación y CompetitividadResearch group RMN190 of the Junta de Andalucí

Sraštenost prstiju uz istodobnu višestruku nerazvijenost mekuši na sve četiri noge sa sekundarnom kontrakturom duboke fleksorne tetive u šteneta.

A 2-month-old, 7 kg, male Belgian shepherd Malinois was presented for evaluation of simple and complete syndactyly a nd metacarpal/tarsal pad agenesis in all four limbs, as well as deep digital flexor tendon contracture in the left thoracic and right pelvic limbs. A deep digital flexor tenotomy (digits 2 to 5) was initially performed at the level of the proximal and middle phalanges in the left thoracic limb. Pelvic limb surgery was not performed because the puppy showed less severe signology in this limb and to evaluate the consequences of the thoracic limb surgery. The patient responded partially, and was then treated with a subsequent bilateral tenotomy made more proximal to the previously described, at the level of the lateral lumbrical muscles in the left thoracic and right pelvic limbs. At 7-month post-operative examination, the patient had minimal lameness, especially regarding concurrent syndactyly and pad agenesis of all extremities that was not treated.U radu je iznesen opis i procjena stanja u dvomjesečnog, 7 kg teškog šteneta, belgijskog Malinois ovčara, s jednostavnom i potpunom sraštenošću prstiju, nerazvijenim metakarpalnim/metatarzalnim mekušina na sve 4 noge te s kontrakturama duboke digitalne fleksorne tetive na lijevoj prednjoj i desnoj stražnjoj nozi. U slučaju prve lijeve noge obavljeno je presjecanje duboke digitalne fleksorne tetive (2. do 5. prsta) na razini gornje i srednje falange. Operacija stražnje noge nije obavljena jer je štene na tom ekstremitetu pokazivalo manje izražene simptome, a željelo se prvo i procjeniti učinke zahvata na prednjoj nozi. Stanje pacijenta djelomično se poboljšalo, stoga je naknadno provedeno bilateralno presijecanje tetiva na mjestu iznad prethodne operacije, na razini lateralnih lumbrikalnih mišića prednje lijeve i stražnje desne noge. Postoperativnom kontrolom nakon 7 mjeseci, kod pacijenta je utvrđena minimalna šepavost, posebice vezana za neliječenu popratnu sraštenost prstiju i nerazvijenost mekuši na svim ekstremitetima

Prevention, Diagnosis and Management of Post-Surgical Mediastinitis in Adults Consensus Guidelines of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Research Centre Network for Respiratory Diseases (CIBERES)

Prevention, Diagnosis and Management of Post-Surgical Mediastinitis in Adults Consensus Guidelines of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Research Centre Network for Respiratory Diseases (CIBERES) doctors and radiologists. Despite the clinical and economic consequences of sternal wound infections, to date, there are no specific guidelines for the prevention, diagnosis and management of mediastinitis based on a multidisciplinary consensus. The purpose of the present document is to provide evidencebased guidance on the most effective diagnosis and management of patients who have experienced or are at risk of developing a post-surgical mediastinitis infection in order to optimise patient outcomes and the process of care. The intended users of the document are health care providers who help patients make decisions regarding their treatment, aiming to optimise the benefits and minimise any harm as well as the workload.Funding: J.M. Miró was a recipient of a personal 80:20 research grant from IDIBAPS during the period 2017–2021

2016 Expert consensus document on prevention, diagnosis and treatment of short-term peripheral venous catheter-related infections in adult.

Aquest document també està publicat a: 'Cirugía Cardiovascular' http://dx.doi.org/10.1016/j.circv.2016.06.001The use of endovascular catheters is a routine practice in secondary and tertiary care level hospitals. Short peripheral catheters have been found to be associated with the risk of nosocomial bacteremia resulting in morbidity and mortality. Staphyloccus aureus is mostly associated with peripheral catheter insertion. This Consensus Document has been elaborated by a panel of experts of the Spanish Society of Cardiovascular Infections in cooperation with experts from the Spanish Society of Internal Medicine, Spanish Society of Chemotherapy and Spanish Society of Thoracic-Cardiovascular Surgery and aims at define and establish the norm for management of short duration peripheral vascular catheters. The document addresses the indications for insertion, catheter maintenance and registry, diagnosis and treatment of infection, indications for removal and stresses on continuous education as a driver for quality. Implementation of this norm will allow uniformity in usage thus minimizing the risk of infection and its complications

Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients

Inflammation is a tightly coordinated response of the host immune system to bacterial and viral infections, triggered by the production of inflammatory cytokines. Sepsis is defined as a systemic inflammatory response followed by immunosuppression of the host and organ dysfunction. This imbalance of the immune response increases the risk of mortality of patients with sepsis, making it a major problem for critical care units worldwide. The P2X7 receptor plays a crucial role in activating the immune system by inducing the activation of peripheral blood mononuclear cells. In this study, we analyzed a cohort of abdominal origin septic patients and found that the expression of the P2X7 receptor in the plasma membrane is elevated in the different subsets of lymphocytes. We observed a direct relationship between the percentage of P2X7-expressing lymphocytes and the early inflammatory response in sepsis. Additionally, in patients whose lymphocytes presented a higher percentage of P2X7 surface expression, the total lymphocytes populations proportionally decreased. Furthermore, we found a correlation between elevated soluble P2X7 receptors in plasma and inflammasome-dependent cytokine IL-18. In summary, our work demonstrates that P2X7 expression is highly induced in lymphocytes during sepsis, and this correlates with IL-18, along with other inflammatory mediators such as IL-6, IL-8, and procalcitonin

Interleukin 6 (rs1800795) gene polymorphism is associated with cardiovascular diseases

Cardiovascular diseases (CVD) are group of complex and multifactorial pathologies, in which interleukin-6 (IL- 6) gene polymorphisms have been associated with several components of the CVD. Thus, in this study, we thoroughly reviewed and meta-analyzed evidence on the association between the IL-6 (rs1800795) gene polymorphism and CVD. We systematically searched in the PubMed, Web of Sciences, and Scopus databases. The analyses were performed using five study groups based on (1) a combined pool of the overall populations, (2) the country of birth, (3) the continent of birth, (4) the diagnosis and (5) both location (country or continent) and diagnosis. The analysis included the allelic, homozygote, heterozygote, dominant and recessive models. The meta-analysisshowed that -174G>C (rs1800795) is a risk factor for CVD (allelic: OR=1.06, CI 95%=1.02-1.10. Z p value C (rs1800795) polymorphism have an increase in the risk of coronary artery disease under the hereditary models assessed in the study. Using robust data, we found that IL-6 (rs1800795) -174G>C gene polymorphism is associated with CVD risk