4,134 research outputs found
Non-Abelian vortex dynamics: Effective world-sheet action
The low-energy vortex effective action is constructed in a wide class of
systems in a color-flavor locked vacuum, which generalizes the results found
earlier in the context of U(N) models. It describes the weak fluctuations of
the non-Abelian orientational moduli on the vortex worldsheet. For instance,
for the minimum vortex in SO(2N) x U(1) or USp(2N) x U(1) gauge theories, the
effective action found is a two-dimensional sigma model living on the Hermitian
symmetric spaces SO(2N)/U(N) or USp(2N)/U(N), respectively. The fluctuating
moduli have the structure of that of a quantum particle state in spinor
representations of the GNO dual of the color-flavor SO(2N) or USp(2N) symmetry,
i.e. of SO(2N) or of SO(2N+1). Applied to the benchmark U(N) model our
procedure reproduces the known CP(N-1) worldsheet action; our recipe allows us
to obtain also the effective vortex action for some higher-winding vortices in
U(N) and SO(2N) theories.Comment: LaTeX, 25 pages, 0 figure
Acquisition and preliminary analysis of multi-channel seismic reflection data, acquired during the oceanographic cruises of the TOMO-ETNA experiment
The TOMO-ETNA experiment was performed in the framework of the FP7 âMED-SUVâ (MEDiterranean SUpersite Volcanoes) in order to gain a detailed geological and structural model of the continental and oceanic crust concerning Etna and Aeolian Islands volcanoes (Sicily, Italy), by means of active and passive seismic exploration methodologies. Among all data collected, some 1410 km of marine multi-channel seismic (MCS) reflection profiles were acquired in the Ionian and Tyrrhenian Seas during two of the three oceanographic cruises of the TOMO-ETNA experiment, in July and November 2014, with the aim of shading light to deep, intermediate and shallow stratigraphy and crustal structure of the two above mentioned areas. The MCS sections, targeted to deep exploration, were acquired during the oceanographic cruise on board of the R/V âSarmiento de Gamboaâ, using an active seismic source of 16 air-guns, for a total volume of 4340 cu. in., and a 3000 m long, 240-channels digital streamer as receiving system. High-resolution seismic profiles were instead collected through the R/V âAegaeoâ, using two smaller air-guns (overall 270 cu. in. volume) and a 96 channels, 300 m long digital streamer. This paper provides a detailed description of the acquisition parameters and main processing steps adopted for the MCS data. Some processed lines are shown and preliminarily interpreted, to highlight the overall good quality and the high potential of the MCS sections collected during the TOMO-ETNA experiment. © 2016 by the Istituto Nazionale di Geofisica e Vulcanologia. All rights reserved
Early triple negative breast cancer: Conventional treatment and emerging therapeutic landscapes
Triple negative breast cancers (TNBCs) are characterized by worse prognosis, higher propensity to earlier metastases, and shorter survival after recurrence compared with other breast cancer subtypes. Anthracycline-and taxane-based chemotherapy is still the mainstay of treatment in early stages, although several escalation approaches have been evaluated to improve survival outcomes. The addition of platinum salts to standard neoadjuvant chemotherapy (NACT) remains controversial due to the lack of clear survival advantage, and the use of adjuvant capecitabine represents a valid treatment option in TNBC patients with residual disease after NACT. Recently, several clinical trials showed promising results through the use of poly ADP-ribose polymerase (PARP) inhibitors and by incorporating immunotherapy with chemotherapy, enriching treatment options beyond conventional cytotoxic agents. In this review, we provided an overview on the current standard of care and a comprehensive update of the recent advances in the management of early stage TNBC and focused on the latest emerging biomarkers and their clinical application to select the best therapeutic strategy in this hard-to-treat population
Neutralino spin measurement with ATLAS detector at LHC
Minimal Supergravity (mSUGRA) [1] Supersimmetry breaking mechanism is a leading candidate for yielding new physics beyond the Standard Model (SM). Within mSUGRA framework masses, mixings and decays of all SUSY and Higgs particles are determined in terms of four input parameters and a sign: the common mass m 0 of scalar particles at the grand unification scale, the common fermion mass m 1/2, the common trilinear coupling A 0, the ratio of the Higgs vacuum expectation values tan ÎČ and the sign of the supersymmetric Higgs mass parameter ÎŒ. Once a signal of a physics beyond the Standard Model is seen at LHC, it will be fundamental to measure properties of new particles, like spin, in order to prove that they are indeed supersymmetric partners. The present work [2] is based on the spin analysis method proposed in [3] and allows the discrimination of different hypotheses for spin assignments. Some studies [4, 5] show that this method can also be used for the discrimination of SUSY from an Universal Extra Dimensions model which can mimick low energy SUSY at hadron colliders. In this report two selected points inside stau-coannihilation and bulk regions of the allowed mSUGRA parameter space are considered. Fast simulation [6] of the ATLAS detector was performed in order to investigate the feasibility of supersymmetric particlesâ spin measurement
Study of second lightest neutralino spin measurement with ATLAS detector at LHC
One of the goals of the ATLAS experiment at the CERN Large Hadron Collider is to search for evidence of Supersymmetry (SUSY) signals. If SUSY would be discovered, it will be fundamental to measure the spin of the new particles in order to prove that they are indeed supersymmetric partners. Left-handed squark cascade decay to second lightest neutralino which further decays to slepton can represent a good opportunity for SUSY particles' spin measurement. Assuming the neutralino spin to be 1/2, the invariant mass distributions of some detectable final products of the reactions have to be charge asymmetric. In the present work the detectability of this charge asymmetry is analysed in the stau-coannihilation region and in the bulk region of the minimal Supergravity parameter space allowed by the latest experimental constraints. The criteria used to isolate the decay chain of interest and to reject the background, coming from both Standard Model and different SUSY decay channels, are described as obtained by suitable optimizations on Monte Carlo samples produced with the ATLAS fast simulation. The estimates of the residual contributions to background and of the applied cut efficiencies are presented. Results on charge asymmetry are then shown and discussed
Matrix Models, Monopoles and Modified Moduli
Motivated by the Dijkgraaf-Vafa correspondence, we consider the matrix model
duals of N=1 supersymmetric SU(Nc) gauge theories with Nf flavors. We
demonstrate via the matrix model solutions a relation between vacua of theories
with different numbers of colors and flavors. This relation is due to an N=2
nonrenormalization theorem which is inherited by these N=1 theories.
Specializing to the case Nf=Nc, the simplest theory containing baryons, we
demonstrate that the explicit matrix model predictions for the locations on the
Coulomb branch at which monopoles condense are consistent with the quantum
modified constraints on the moduli in the theory. The matrix model solutions
include the case that baryons obtain vacuum expectation values. In specific
cases we check explicitly that these results are also consistent with the
factorization of corresponding Seiberg-Witten curves. Certain results are
easily understood in terms of M5-brane constructions of these gauge theories.Comment: 27 pages, LaTeX, 2 figure
Selective formation, reactivity, redox and magnetic properties of MnIII and FeIII dinuclear complexes with shortened salen-type schiff base ligands
The reactivity of the shortened salen-type ligands H3salmp, H2salmen and H2sal(p-X)ben with variable para-substituent on the central aromatic ring (X = tBu, Me, H, F, Cl, CF3, NO2) towards the trivalent metal ions manganese(III) and iron(III) is presented. The selective formation of the dinuclear complexes [M2(m-salmp)2], M = Mn (1a), Fe (2a), [M2(m-salmen)2(m-OR)2)], R = Et, Me, H and M = Mn (3a\u2013c) or Fe (4a\u2013c), and (M2(m-sal[p-X]ben)2(m-OMe)2), X = tBu, Me, H, F, Cl, CF3, NO2 and M = Mn (5a\u2013g) or Fe (6a\u2013g), could be identified by reaction of the Schiff bases with metal salts and the base NEt3, and their characterization through elemental analysis, infrared spectroscopy, mass spectrometry and single-crystal X-ray diffraction of 2a.2AcOEt, 2a.2CH3CN and 3c.2DMF was performed. In the case of iron(III) and H3salmp, when using NaOH as a base instead of NEt3, the dinuclear complexes [Fe2(m-salmp)(m-OR)(salim)2], R = Me, H (2b\u2013c) could be isolated and spectroscopically characterized, including the crystal structure of 2b.1.5H2O, which showed that rupture of one salmp3\u2013 to two coordinated salim\u2013 ligands and release of one salH molecule occurred. The same hydrolytic tendency could be identified with sal(p-X)ben ligands in the case of iron(III) also by using NEt3 or upon standing in solution, while manganese(III) did not promote such a C\u2013N bond breakage. Cyclic voltammetry studies were performed for 3b, 4b, 5a and 6a, revealing that the iron(III) complexes can be irreversibly reduced to the mixed-valence FeIIFeIII and FeII2 dinuclear species, while the manganese(III) derivatives can be reversibly oxidized to either the mixed-valence MnIIIMnIV or to the MnIV2 dinuclear species. The super-exchange interaction between the metal centers, mediated by the bridging ligands, resulted in being antiferromagnetic (AFM) for the selected dinuclear compounds 3b, 4b, 5a, 5e, 5f, 6a and 6e. The coupling constants J (\u20132J \u15c1\ub7\u15c2 formalism) had values around \u201313 cm\u20131 for manganese(III) compounds, among the largest AFM coupling constants reported so far for dinuclear MnIII2 derivatives, while values between \u20133 and \u201310 cm\u20131 were obtained for iron(III) compounds
Genome-scaled phylogeny of Saccharomyces cerevisiae from spontaneous must fermentations
Modern winemakers commonly inoculate selected S. cerevisiae strains in must to obtain controlled fermentations and reproducible products. However, wine has been produced for thousands of years using spontaneous fermentations from wild strains, a practice that is experiencing a revival among small wine producers. Despite the widespread usage of such strains in the past, there is much to know about their ecology, evolution and functional potential. For example, the reciprocal affinities of these strains within the S. cerevisiae phylogeny have yet to be discovered, as well as the degree of their biodiversity and their impact on wine terroir. To fill this knowledge gap, we aim at characterising at strain level the S. cerevisiae present in spontaneously fermented musts sampled across Italy. We set up a protocol based on polyphenols-removing prewashes, followed by whole-genome shotgun sequencing at a depth of 5Gb of DNA per sample. We performed both an assembly-free analysis to reconstruct the strain-level phylogeny of S. cerevisiae strains using the species-specific-marker based StrainPhlAn, and the reconstruction of Metagenome-Assembled Genomes of these strains for downstream functional analyses. To plan conservation acts in a scenario of continuous climate change, we aim at isolating and maintaining strains of interest. We will present preliminary results from the analysis of spontaneous musts sampled at different fermenting stages
Prognostic Relevance of Progesterone Receptor Levels in Early Luminal-Like HER2 Negative Breast Cancer Subtypes: A Retrospective Analysis
Balanced Propofol Sedation in Patients Undergoing EUS-FNA: A Pilot Study to Assess Feasibility and Safety
Introduction and aims. Balanced propofol sedation (BPS) administered by gastroenterologists has gained popularity in endoscopic procedures. Few studies exist about the safety of this approach during endosonography with fine needle aspiration (EUS-FNA). We assessed the safety of BPS in EUS-FNA. Materials and methods. 112 consecutive patients, referred to our unit to perform EUS-FNA, from February 2008 to December 2009, were sedated with BPS. A second gastroenterologist administered the drugs and monitorized the patient. Results. All the 112 patients (62 males, mean age 58.35) completed the examination. The mean dose of midazolam and propofol was, respectively, of 2.1âmg (range 1â4âmg) and 350âmg (range 180â400). All patients received oxygen with a mean flux of 4 liter/minute (range 2â6 liters/minute). The mean recovery time after procedure was 25 minutes (range 18â45 minutes). No major complications related to sedation were registered during all procedures. The oxygen saturation of all patients never reduced to less than 85%. Blood systolic pressure during and after the procedure never reduced to less than 100âmmHg. Conclusions. In our experience BPS administered by non-anaesthesiologists provided safe and successful sedation in patients undergoing EUS-FNA
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