Primary Pulmonary Adenocarcinoma in a Cow

Background: Primary neoplasms of the respiratory tract are rare in cattle, and they present with nonspecific clinical signs and are usually found at post-mortem. Pulmonary adenocarcinoma of the acinar type is uncommon, and information about this neoplasm in cattle is scarce. This paper aims to describe the clinical, laboratory, and pathological findings in a cow with this neoplasm.Case: A 10-year-old, adult, mixed-breed Holstein cow weighing 300 kg was referred to the Garanhuns Cattle Clinic of the Campus of Federal Rural University of Pernambuco, Brazil, with a history of decreased appetite, tiredness, weight loss, and difficulty in breathing for two months. The animal had been treated at the farm of origin with enrofloxacin, florfenicol, and flunixin meglumine. The animal’s appetite improved, but no improvement in the respiratory symptoms was observed. On examination at our center, the cow was in an orthopedic position, with neck extension and elbow abduction; and it remained in a recumbent position. The cow had neutrophilia, normochromic normocytic anemia, and hyperfibrinogemia. The body condition score (BCS) was 1 (BCS ranges from 1 to 5), and the cow had moderate enophthalmia, serous secretions in nostrils, tachycardia, and tachypnea. It also had increased breathing intensity; increased breath sounds in the cranial regions of both lungs; areas of reduced breath sounds in the medial portions of the lungs; intermittent wheezing in the cranial region of the left lung medially and in the cranial region of the right lung medially; intermittent crepitations in the cranial region of the right lung medially; reduced thoracic expansion; and expiratory dyspnea. Pulmonary ultrasonography revealed hyperechogenic multifocal structures in both lungs. In view of the severe clinical condition and unfavorable prognosis, the owner opted for euthanasia. Necropsy revealed that there was a significant amount of yellow fluid in the thoracic cavity, and the cut surfaces of the lungs were covered with fibrin and pleural adhesions. The lungs had irregular surfaces with multifocal nodules of various sizes and firm consistency. The texture of the cut nodules was solid, and the nodules had a yellowish color. Histologically, the pulmonary nodules were composed of neoplastic cells. They were pleomorphic, infiltrative epithelial cells with little cytoplasm; large and spherical nuclei with abundant euchromatin; occasional anisokaryosis; visible nucleolus; and numerous mitotic figures. Results of anti-cytokeratin immunohistochemistry were strongly positive for cytokeratin in the lungs and lymph nodes. Discussion: The diagnosis of acinar pulmonary adenocarcinoma was based on clinical, laboratory, histopathological, and immunohistochemical findings. Clinical signs and lung ultrasound suggested a severe respiratory disease. Pulmonary tumors are usually solid, and they show areas of central necrosis that resemble granulomas. However, the histopathological findings in the current case were compatible with a primary pulmonary neoplasm. Primary pulmonary neoplasms, although rare, should be considered in the differential diagnosis of weight loss, cachexia, and respiratory symptoms in adult cattle. The morphological pattern and the strong immunoreactivity on immunohistochemical examination were conclusive for a diagnosis of a primary pulmonary adenocarcinoma of the acinar type because these tumors specifically contain cytokeratin

Análise do aprazamento de enfermagem em uma UTI: foco na segurança do paciente / Analysis of nursing aprazamento in an ICU: focus on patient safety

Objetivo: Identificar as não conformidades relacionadas ao aprazamento medicamentoso. Método: Trata-se de um estudo transversal, descritivo, com análise documental e abordagem quantitativa, realizado em uma Unidade de Terapia Intensiva Geral de um hospital universitário do Rio de Janeiro. Resultados: Foram analisadas 362 prescrições. As não conformidades encontradas foram: aprazamento com intervalos não condizentes com a prescrição (80,5%), ausência do carimbo do responsável pelo aprazamento (46%), aprazamento em medicações à critério médico ou suspensas (19%), dentre outros. Conclusão: Ações de enfermagem que poderiam ser realizadas como barreiras frente as não conformidades encontradas seriam: continuação da dupla checagem, elaboração de um guia para o aprazamento; um local privativo para a realização do aprazamento ou utilização de uma sinalização na roupa do aprazador e aprazamento com sistema digital a fim de evitar interações. Descritores: Erros de medicação, Segurança do paciente, Enfermagem de cuidados crítico

Análise do aprazamento de enfermagem em uma UTI: foco na segurança do paciente / Analysis of nursing aprazamento in an ICU: focus on patient safety

Objetivo: Identificar as não conformidades relacionadas ao aprazamento medicamentoso. Método: Trata-se de um estudo transversal, descritivo, com análise documental e abordagem quantitativa, realizado em uma Unidade de Terapia Intensiva Geral de um hospital universitário do Rio de Janeiro. Resultados: Foram analisadas 362 prescrições. As não conformidades encontradas foram: aprazamento com intervalos não condizentes com a prescrição (80,5%), ausência do carimbo do responsável pelo aprazamento (46%), aprazamento em medicações à critério médico ou suspensas (19%), dentre outros. Conclusão: Ações de enfermagem que poderiam ser realizadas como barreiras frente as não conformidades encontradas seriam: continuação da dupla checagem, elaboração de um guia para o aprazamento; um local privativo para a realização do aprazamento ou utilização de uma sinalização na roupa do aprazador e aprazamento com sistema digital a fim de evitar interações.Descritores: Erros de medicação, Segurança do paciente, Enfermagem de cuidados crítico

Câncer de pele: Prevalência e epidemiologia em um hospital de ensino da cidade de Juiz de Fora – MG / Skin cancer: Prevalence and epidemiology at a teaching hospital in the city of Juiz de Fora – MG

O câncer de pele (CP) é uma patologia altamente prevalente, de etiologia multifatorial, e que se apresenta epidemiologicamente, na forma de CP melanoma (CPM) e CP não-melanoma (CPNM). Esta representada pelo carcinoma basocelular (CBC) e pelo carcinoma epidermóide (CEC). O CBC é o tipo mais frequente apresentando o melhor prognóstico, ao contrário do CPM que representa cerca de 3% dos casos e é o mais agressivo, uma vez que pode apresentar metástases de variadas gravidades. Quando o CP é diagnosticado precocemente e tratado de forma adequada isso confere um melhor prognóstico ao paciente e uma diminuição da morbimortalidade. Dessa forma, nosso estudo tem como objetivo analisar o perfil epidemiológico e a prevalência do CP em pacientes atendidos no município de Juiz de Fora, MG

Reservas estratégicas de água subterrânea na Região Centro (Projecto Images)

Comunicação apresentada em Powerpoint, composta por 12 slide

Effects of feeding cassava bagasse to slow-growing broilers / Bagaço de mandioca na alimentação de frangos de crescimento lento

The aim was to determine the energy and nutritional value of cassava bagasse (CB) and to evaluate its use for feeding slow-growing broilers. Two experiments were conducted. In the first experiment, a digestibility assay was performed to determine the apparent metabolizable energy (AME) and apparent metabolizable energy corrected for nitrogen balance (AMEn), as well as the apparent metabolizability coefficients of dry matter, crude protein and ether extract. The CB had 88.46% dry matter (DM); 1.26% crude protein (CP); 3.86% ether extract (EE); 1.06% ash and 3565 kcal/kg of gross energy. The determined values of AME and AMEn were 2508.74 kcal/kg and 2465.30 kcal/kg, respectively. The coefficients were 69.15%; 53.59% and 84.55% for DM, CP and EE; respectively. The second experiment was performed to evaluate the performance, biometry of the digestive tract and blood parameters of slow-growing broilers fed different inclusion levels (0%, 10%, 20% and 30%) of CB. In the starter phase, the inclusion of CB negatively affected feed intake (FI), weight gain (WG), whereas feed conversion (FC) had a quadratic response, with the best estimated conversion at 10.39% of CB. Blood parameters in the starter phase were not influenced by CB inclusion. In the growing phase, the inclusion of CB negatively affected the WG, FC and final weight (FW). In the finishing phase, CB did not affect performance regardless of its inclusion, except for the final weight and carcass yield that were negatively affected. Relative to biometry, there was only an effect on the relative weight of the small intestine, which increased linearly. Glucose, triglycerides and cholesterol in the growing and finishing phases were not influenced by the CB levels. On the other hand, there was a quadratic effect for total protein with a maximum level of 4.74 g/dL at 10% inclusion in the growing phase, whereas uric acid increased as CB inclusion increased in the finishing phase. Based on the results of performance, biometry and blood parameters, CB can be added to slow-growing broilers diets in the starter phase up to 10.39%. The inclusion of CB in growing diets is not recommended, whereas it can be used up to the 30% without affecting the performance of slow-growing broilers in the finishing phase

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio