A follow-up of the male graduates of Braintree High School with regard to the industrial-arts program.

Thesis (Ed.M.)--Boston Universit

Multimodal Data at Signalized Intersections: Strategies for Archiving Existing and New Data Streams to Support Operations and Planning & Fusion and Integration of Arterial Performance Data

There is a growing interest in arterial system management due to the increasing amount of travel on arterials and a growing emphasis on multimodal transportation. The benefits of archiving arterial-related data are numerous. This research report describes our efforts to assemble and develop a multimodal archive for the Portland-Vancouver region. There is coverage of data sources from all modes in the metropolitan region; however, the preliminary nature of the archiving process means that some of the data are incomplete and samples. The arterial data sources available in the Portland-Vancouver region and that are covered in this report include data for various local agencies (City of Portland, Clark County, WA, TriMet and C-TRAN) covering vehicle, transit, pedestrian, and bicycle modes. We provide detailed descriptions of each data source and a spatial and temporal classification. The report describes the conceptual framework for an archive and the data collection and archival process, including the process for extracting the data from the agency systems and transferring these data to our multimodal database. Data can be made more useful though the use of improved visualization techniques. Thus as part of the project, a number of novel, online visualizations were created and implemented. These graphs and displays are summarized in this report and example visualizations are shown. As with any automated sensor system, data quality and completeness is an important issue and the challenge of automating data quality is large. Preliminary efforts to validate and monitor data quality and automate data quality processing are explored. Finally, the report presents efforts to combine transit and travel time data and signal timing and vehicle count data to generate some sample congestion measures

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient mitochondrial pyruvate uptake. In contrast, proliferative cells, including many cancer and stem cells, perform glycolysis robustly but limit fractional mitochondrial pyruvate oxidation. We sought to understand the role this transition from glycolysis to pyruvate oxidation plays in stem cell maintenance and differentiation. Loss of the MPC in Lgr5-EGFP-positive stem cells, or treatment of intestinal organoids with an MPC inhibitor, increases proliferation and expands the stem cell compartment. Similarly, genetic deletion of the MPC in Drosophila intestinal stem cells also increases proliferation, whereas MPC overexpression suppresses stem cell proliferation. These data demonstrate that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis

Measurements of ϕ\phi meson production in relativistic heavy-ion collisions at RHIC

We present results for the measurement of $\phi$ meson production via its charged kaon decay channel $\phi \to K^+K^-$ in Au+Au collisions at $\sqrt{s_{_{NN}}}=62.4$, 130, and 200 GeV, and in $p+p$ and $d$+Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV from the STAR experiment at the BNL Relativistic Heavy Ion Collider (RHIC). The midrapidity ($|y|<0.5$) $\phi$ meson transverse momentum ($p_{T}$) spectra in central Au+Au collisions are found to be well described by a single exponential distribution. On the other hand, the $p_{T}$ spectra from $p+p$, $d$+Au and peripheral Au+Au collisions show power-law tails at intermediate and high $p_{T}$ and are described better by Levy distributions. The constant $\phi/K^-$ yield ratio vs beam species, collision centrality and colliding energy is in contradiction with expectations from models having kaon coalescence as the dominant mechanism for $\phi$ production at RHIC. The $\Omega/\phi$ yield ratio as a function of $p_{T}$ is consistent with a model based on the recombination of thermal $s$ quarks up to $p_{T}\sim 4$ GeV/$c$, but disagrees at higher transverse momenta. The measured nuclear modification factor, $R_{dAu}$, for the $\phi$ meson increases above unity at intermediate $p_{T}$, similar to that for pions and protons, while $R_{AA}$ is suppressed due to the energy loss effect in central Au+Au collisions. Number of constituent quark scaling of both $R_{cp}$ and $v_{2}$ for the $\phi$ meson with respect to other hadrons in Au+Au collisions at $\sqrt{s_{_{NN}}}$=200 GeV at intermediate $p_{T}$ is observed. These observations support quark coalescence as being the dominant mechanism of hadronization in the intermediate $p_{T}$ region at RHIC.Comment: 22 pages, 21 figures, 4 table

Enhanced strange baryon production in Au+Au collisions compared to p+p at sqrts = 200 GeV

We report on the observed differences in production rates of strange and multi-strange baryons in Au+Au collisions at sqrts = 200 GeV compared to pp interactions at the same energy. The strange baryon yields in Au+Au collisions, then scaled down by the number of participating nucleons, are enhanced relative to those measured in pp reactions. The enhancement observed increases with the strangeness content of the baryon, and increases for all strange baryons with collision centrality. The enhancement is qualitatively similar to that observed at lower collision energy sqrts =17.3 GeV. The previous observations are for the bulk production, while at intermediate pT, 1 < pT< 4 GeV/c, the strange baryons even exceed binary scaling from pp yields.Comment: 7 pages, 4 figures. Printed in PR

Strangelet Search in AuAu Collisions at 200 GeV

We have searched for strangelets in a triggered sample of 61 million central (top 4%) Au+Au collisions at \sNN = 200 GeV near beam rapidities at the STAR detector. We have sensitivity to metastable strangelets with lifetimes of order $\geq 0.1 ns$, in contrast to limits over ten times longer in AGS studies and longer still at the SPS. Upper limits of a few 10^{-6} to 10^{-7} per central Au+Au collision are set for strangelets with mass ${}^{>}_{\sim}30$ GeV/c^{2}.Comment: As publishe

Studying Parton Energy Loss in Heavy-Ion Collisions via Direct-Photon and Charged-Particle Azimuthal Correlations

Charged-particle spectra associated with direct photon ($\gamma_{dir}$) and $\pi^0$ are measured in $p$+$p$ and Au+Au collisions at center-of-mass energy $\sqrt{s_{_{NN}}}=200$ GeV with the STAR detector at RHIC. A hower-shape analysis is used to partially discriminate between $\gamma_{dir}$ and $\pi^0$. Assuming no associated charged particles in the $\gamma_{dir}$ direction (near side) and small contribution from fragmentation photons ($\gamma_{frag}$), the associated charged-particle yields opposite to $\gamma_{dir}$ (away side) are extracted. At mid-rapidity ($|\eta|<0.9$) in central Au+Au collisions, charged-particle yields associated with $\gamma_{dir}$ and $\pi^0$ at high transverse momentum ($8< p_{T}^{trig}<16$ GeV/$c$) are suppressed by a factor of 3-5 compared with $p$ + $p$ collisions. The observed suppression of the associated charged particles, in the kinematic range $|\eta|<1$ and $3< p_{T}^{assoc} < 16$ GeV/$c$, is similar for $\gamma_{dir}$ and $\pi^0$, and independent of the $\gamma_{dir}$ energy within uncertainties. These measurements indicate that the parton energy loss, in the covered kinematic range, is insensitive to the parton path length.Comment: submitted to Phys. Rev. Lett, 6 pages, 4 figure

Minijet deformation and charge-independent angular correlations on momentum subspace (η,ϕ)(\eta,\phi) in Au-Au collisions at sNN\sqrt{s_{NN}} = 130 GeV

First measurements of charge-independent correlations on angular difference variables $\eta_1 - \eta_2$ (pseudorapidity) and $\phi_1 - \phi_2$ (azimuth) are presented for primary charged hadrons with transverse momentum $0.15 \leq p_t \leq 2$ GeV/$c$ and $|\eta| \leq 1.3$ from Au-Au collisions at $\sqrt{s_{NN}} = 130$ GeV. Strong charge-independent angular correlations are observed associated with jet-like structures and elliptic flow. The width of the jet-like peak on $\eta_1 - \eta_2$ increases by a factor 2.3 from peripheral to central collisions, suggesting strong coupling of semi-hard scattered partons to a longitudinally-expanding medium. New methods of jet analysis introduced here provide evidence for nonperturbative QCD medium effects in heavy ion collisions.Comment: 8 pages, 4 figure