Adhesion of platelets to colon cancer cells is necessary to promote tumor development in xenograft, genetic and inflammation models

Platelets represent the linkage between tissue damage and inflammatory response with a putative role in tumorigenesis. Given the importance of the microenvironment in colon cancer development, we elucidated the eventual role of platelets‐cancer cells crosstalk in in vivo colon cancer models. To evaluate the involvement of platelets in intestinal tumorigenesis, we first analyzed if the ablation of β‐integrin P‐selectin that drives platelets‐cell adhesion, would contribute to platelets‐colon cancer cell interaction and drive cancer progression. In a xenograft tumor model, we observed that when tumors are inoculated with platelets, the ablation of P‐selectin significantly reduced tumor growth compared to control platelets. Furthermore, in genetic models, as well as in chronic colitis‐associated colorectal carcinogenesis, P‐selectin ablated mice displayed a significant reduction in tumor number and size compared to control mice. Taken together, our data highlights the importance of platelets in the tumor microenvironment for intestinal tumorigenesis. These results support the hypothesis that a strategy aimed to inhibit platelets adhesion to tumor cells are able to block tumor growth and could represent a novel therapeutic approach to colon cancer treatment

Fidelity of Thermococcus litoralis DNA polymerase (Vent TM ) in PCR determined by denaturing gradient gel electrophoresis

DNA synthesis fidelities of two thermostable DNA polymerases, Thermus aquaticus (Taq) and Thermococcus litoralis (Tli, also known as Ven

Phomopsis bougainvilleicola prepatellar bursitis in a renal transplant recipient

Prepatellar bursitis is typically a monomicrobial bacterial infection. A fungal cause is rarely identified. We describe a 61-year-old man who had received a renal transplant 21 months prior to presentation whose synovial fluid and surgical specimens grew Phomopsis bougainvilleicola, a pycnidial coelomycete

On elliptic solutions of the cubic complex one-dimensional Ginzburg-Landau equation

The cubic complex one-dimensional Ginzburg-Landau equation is considered. Using the Hone's method, based on the use of the Laurent-series solutions and the residue theorem, we have proved that this equation has neither elliptic standing wave nor elliptic travelling wave solutions. This result amplifies the Hone's result, that this equation has no elliptic travelling wave solutions.Comment: LaTeX, 12 page

Lineability within probability theory settings

[EN] The search of lineability consists on finding large vector spaces of mathematical objects with special properties. Such examples have arisen in the last years in a wide range of settings such as in real and complex analysis, sequence spaces, linear dynamics, norm-attaining functionals, zeros of polynomials in Banach spaces, Dirichlet series, and non-convergent Fourier series, among others. In this paper we present the novelty of linking this notion of lineability to the area of Probability Theory by providing positive (and negative) results within the framework of martingales, random variables, and certain stochastic processes.This work was partially supported by Ministerio de Educacion, Cultura y Deporte, projects MTM2013-47093-P and MTM2015-65825-P, by the Basque Government through the BERC 2014-2017 program and by the Spanish Ministerio de Economia y Competitividad: BCAM Severo Ochoa excellence accreditation SEV-2013-0323.Conejero, JA.; Fenoy, M.; Murillo Arcila, M.; Seoane Sepúlveda, JB. (2017). Lineability within probability theory settings. Revista de la Real Academia de Ciencias Exactas Físicas y Naturales Serie A Matemáticas. 111(3):673-684. https://doi.org/10.1007/s13398-016-0318-yS6736841113Aizpuru, A., Pérez-Eslava, C., García-Pacheco, F.J., Seoane-Sepúlveda, J.B.: Lineability and coneability of discontinuous functions on $$\mathbb{R}$$ R . Publ. Math. Debrecen 72(1–2), 129–139 (2008)Aron, R., Gurariy, V.I., Seoane, J.B.: Lineability and spaceability of sets of functions on $$\mathbb{R}$$ R . Proc. Am. Math. Soc. 133(3), 795–803 (2005, electronic)Aron, R.M., González, L.B., Pellegrino, D.M., Sepúlveda J.B.S.: Lineability: the search for linearity in mathematics. Monographs and Research Notes in Mathematics. CRC Press, Boca Raton (2016)Ash, R.B.: Real analysis and probability. Probability and mathematical statistics, No. 11. Academic Press, New York-London (1972)Barbieri, G., García-Pacheco, F.J., Puglisi, D.: Lineability and spaceability on vector-measure spaces. Stud. Math. 219(2), 155–161 (2013)Bernal-González, L., Cabrera, M.O.: Lineability criteria, with applications. J. Funct. Anal. 266(6), 3997–4025 (2014)Bernal-González, L., Pellegrino, D., Seoane-Sepúlveda, J.B.: Linear subsets of nonlinear sets in topological vector spaces. Bull. Am. Math. Soc. (N.S.), 51(1), 71–130 (2014)Berndt, B.C.: What is a $$q$$ q -series? In: Ramanujan rediscovered, Ramanujan Math. Soc. Lect. Notes Ser., vol. 14, pp. 31–51. Ramanujan Math. Soc., Mysore (2010)Bertoloto, F.J., Botelho, G., Fávaro, V.V., Jatobá, A.M.: Hypercyclicity of convolution operators on spaces of entire functions. Ann. Inst. Fourier (Grenoble) 63(4), 1263–1283 (2013)Billingsley, P.: Probability and measure. Wiley Series in Probability and Mathematical Statistics, 3rd edn, A Wiley-Interscience Publication. Wiley, New York (1995)Botelho, G., Fávaro, V.V.: Constructing Banach spaces of vector-valued sequences with special properties. Mich. Math. J. 64(3), 539–554 (2015)Cariello, D., Seoane-Sepúlveda, J.B.: Basic sequences and spaceability in $$\ell _p$$ ℓ p spaces. J. Funct. Anal. 266(6), 3797–3814 (2014)Drewnowski, L., Lipecki, Z.: On vector measures which have everywhere infinite variation or noncompact range. Dissertationes Math. (Rozprawy Mat.) 339, 39 (1995)Dugundji, J.: Topology. Allyn and Bacon, Inc., Boston, Mass.-London-Sydney (1978, Reprinting of the 1966 original, Allyn and Bacon Series in Advanced Mathematics)Enflo, P.H., Gurariy, V.I., Seoane-Sepúlveda, J.B.: Some results and open questions on spaceability in function spaces. Trans. Am. Math. Soc. 366(2), 611–625 (2014)Fonf, V.P., Zanco, C.: Almost overcomplete and almost overtotal sequences in Banach spaces. J. Math. Anal. Appl. 420(1), 94–101 (2014)Gámez-Merino, J.L., Seoane-Sepúlveda, J.B.: An undecidable case of lineability in $$\mathbb{R}^{\mathbb{R}}$$ R R . J. Math. Anal. Appl. 401(2), 959–962 (2013)Gurariĭ, V.I.: Linear spaces composed of everywhere nondifferentiable functions. C. R. Acad. Bulgare Sci. 44(5), 13–16 (1991)Muñoz-Fernández, G.A., Palmberg, N., Puglisi, D., Seoane-Sepúlveda, J.B.: Lineability in subsets of measure and function spaces. Linear Algebra Appl. 428(11–12), 2805–2812 (2008)Walsh, J.B.: Martingales with a multidimensional parameter and stochastic integrals in the plane. In: Lectures in probability and statistics (Santiago de Chile, 1986), Lecture Notes in Math., vol. 1215, pp. 329–491. Springer, Berlin (1986)Wise, G.L., Hall, E.B.: Counterexamples in probability and real analysis. The Clarendon Press, Oxford University Press, New York (1993

Solitary waves of nonlinear nonintegrable equations

Our goal is to find closed form analytic expressions for the solitary waves of nonlinear nonintegrable partial differential equations. The suitable methods, which can only be nonperturbative, are classified in two classes. In the first class, which includes the well known so-called truncation methods, one \textit{a priori} assumes a given class of expressions (polynomials, etc) for the unknown solution; the involved work can easily be done by hand but all solutions outside the given class are surely missed. In the second class, instead of searching an expression for the solution, one builds an intermediate, equivalent information, namely the \textit{first order} autonomous ODE satisfied by the solitary wave; in principle, no solution can be missed, but the involved work requires computer algebra. We present the application to the cubic and quintic complex one-dimensional Ginzburg-Landau equations, and to the Kuramoto-Sivashinsky equation.Comment: 28 pages, chapter in book "Dissipative solitons", ed. Akhmediev, to appea

A poly(urethane)-encapsulated benzo[2,3-d:6,7-d']diimidazole organic down-converter for green hybrid LEDs

The development of organic down-converting materials continues to attract attention in hybrid LED technology by obviating the need for non-sustainable rare-earth elements. In this work, a benzodiimidazole-based system (TPA-BDI) has been employed as a down-converting layer in a hybrid organic-inorganic LED device. A commercially available poly(urethane)-based resin is used as the encapsulating material, providing a dilute layer of TPA-BDI that is deposited on top of the GaN-based LED. Crucially, the solution-state emissive performance is generally maintained when encapsulated at low concentrations within this resin. A maximum luminous efficacy of 87 lm W -1 was demonstrated using a 1.0 mg ml -1 concentration of TPA-BDI in the resin. The suitability of using organic down-converters to produce green light from hybrid devices was demonstrated by the excellent repeatability of the device characteristics across a series of encapsulated LEDs

Living between languages: The politics of translation in Leila Aboulela’s Minaret and Xiaolu Guo’s A Concise Chinese-English Dictionary for Lovers

This is the author's final draft post-refereeing as published in The Journal of Commonwealth Literature 2012 47: 207 DOI:10.1177/0021989412440433. The online version of this article can be found at: http://jcl.sagepub.com/content/47/2/20