Galaxy density profiles and shapes -- II. selection biases in strong lensing surveys

[Abridged] Many current and future astronomical surveys will rely on samples of strong gravitational lens systems to draw conclusions about galaxy mass distributions. We use a new strong lensing pipeline (presented in Paper I of this series) to explore selection biases that may cause the population of strong lensing systems to differ from the general galaxy population. Our focus is on point-source lensing by early-type galaxies with two mass components (stellar and dark matter) that have a variety of density profiles and shapes motivated by observational and theoretical studies of galaxy properties. We seek not only to quantify but also to understand the physics behind selection biases related to: galaxy mass, orientation and shape; dark matter profile parameters such as inner slope and concentration; and adiabatic contraction. We study how all of these properties affect the lensing Einstein radius, total cross-section, quad/double ratio, and image separation distribution. We find significant (factors of several) selection biases with mass; orientation, for a given galaxy shape at fixed mass; cusped dark matter profile inner slope and concentration; concentration of the stellar and dark matter deprojected Sersic models. Interestingly, the intrinsic shape of a galaxy does not strongly influence its lensing cross-section when we average over viewing angles. Our results are an important first step towards understanding how strong lens systems relate to the general galaxy population.Comment: 26 pages, 15 figures; paper I at arXiv:0808.2493; accepted for publication in MNRAS (minor revisions); PDF file with full resolution figures at http://www.sns.ias.edu/~rmandelb/paper2.pd

Galaxy density profiles and shapes -- I. simulation pipeline for lensing by realistic galaxy models

Studies of strong gravitational lensing in current and upcoming wide and deep photometric surveys, and of stellar kinematics from (integral-field) spectroscopy at increasing redshifts, promise to provide valuable constraints on galaxy density profiles and shapes. However, both methods are affected by various selection and modelling biases, whch we aim to investigate in a consistent way. In this first paper in a series we develop a flexible but efficient pipeline to simulate lensing by realistic galaxy models. These galaxy models have separate stellar and dark matter components, each with a range of density profiles and shapes representative of early-type, central galaxies without significant contributions from other nearby galaxies. We use Fourier methods to calculate the lensing properties of galaxies with arbitrary surface density distributions, and Monte Carlo methods to compute lensing statistics such as point-source lensing cross-sections. Incorporating a variety of magnification bias modes lets us examine different survey limitations in image resolution and flux. We rigorously test the numerical methods for systematic errors and sensitivity to basic assumptions. We also determine the minimum number of viewing angles that must be sampled in order to recover accurate orientation-averaged lensing quantities. We find that for a range of non-isothermal stellar and dark matter density profiles typical of elliptical galaxies, the combined density profile and corresponding lensing properties are surprisingly close to isothermal around the Einstein radius. The converse implication is that constraints from strong lensing and/or stellar kinematics, which are indeed consistent with isothermal models near the Einstein radius, cannot trivially be extrapolated to smaller and larger radii.Comment: 31 pages, 15 figures; paper II at arXiv:0808.2497; accepted for publication in MNRAS; PDF file with full resolution figures at http://www.sns.ias.edu/~glenn/paper1.pd

A política econômica brasileira

Política econômica em uma economia capitalista é o processo através do qual o Estado intervém no mercado, corrigindo-o e orientando-o para determinados objetivos. Se o mercado funcionasse da maneira absolutamente perfeita com a qual os economistas ortodoxos sonham, não haveria lugar para a política econômica. Tratando-se do reconhecimento e de fazer uma abordagem sobre os problemas econômicos, tornou-se imprescindível o enquadramento da política econômica nos domínios da Economia Política, seja para estabelecer os pontos de contato entre ela e a análise econômica ou para destacar as peculiaridades da abordagem política dos fenômenos econômicos

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents

Imeglimin is a promising new oral antihyperglycemic agent that has been studied in clinical trials as a possible monotherapy or add-on therapy to lower fasting plasma glucose and improve hemoglobin A(1c) (1–3, 9). Imeglimin was shown to improve both fasting and postprandial glycemia and to increase insulin secretion in response to glucose during a hyperglycemic clamp after 1-wk of treatment in type 2 diabetic patients. However, whether the β-cell stimulatory effect of imeglimin is solely or partially responsible for its effects on glycemia remains to be fully confirmed. Here, we show that imeglimin directly activates β-cell insulin secretion in awake rodents without affecting hepatic insulin sensitivity, body composition, or energy expenditure. These data identify a primary amplification rather than trigger the β-cell mechanism that explains the acute, antidiabetic activity of imeglimin

Sideline Testing in Youth and Collegiate Athletes

"Identification of rapid yet simple diagnostic tests for sports-related concussion is critical. These tests must be age-appropriate and capture relevant aspects of brain function. Vision encompasses nearly 50% of the brain's pathways, yet is not represented in current sideline testing protocols. We examined the King-Devick (K-D) test, a vision-based measure of rapid number naming, as a complement to the Sport Concussion Assessment Tool, 3rd Edition (SCAT3/Child-SCAT3) in youth and collegiate athletes.

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

Obesity, insulin resistance and the metabolic syndrome are associated with changes to the gut microbiota; however, the mechanism by which modifications to the gut microbiota might lead to these conditions is unknown. Here we show that increased production of acetate by an altered gut microbiota leads to activation of the parasympathetic nervous system which in turn promotes increased glucose-stimulated insulin secretion (GSIS), increased ghrelin secretion, hyperphagia, obesity and its related sequelae (Extended Data Fig. 1). Taken together, these data identify increased acetate production by a nutrient-gut microbiota interaction and subsequent parasympathetic activation as possible therapeutic targets for obesity