Testing a dissipative kinetic k-essence model

In this work, we present a study of a purely kinetic k-essence model, characterized basically by a parameter $\alpha$ in presence of a bulk dissipative term, whose relationship between viscous pressure $\Pi$ and energy density $\rho$ of the background follows a polytropic type law $\Pi \propto \rho^{\lambda+1/2}$, where $\lambda$, in principle, is a parameter without restrictions. Analytical solutions for the energy density of the k-essence field are found in two specific cases: $\lambda=1/2$ and $\lambda=(1-\alpha)/2\alpha$, and then we show that these solutions posses the same functional form than the non-viscous counterpart. Finally, both approach are contrasted with observational data from type Ia supernova, and the most recent Hubble parameter measurements, and therefore, the best values for the parameters of the theory are founds.Comment: 9 pages, 5 figures, accepted in EPJ

Testing cosmic acceleration for w(z)w(z) parameterizations using fgasf_{gas} measurements in galaxy clusters

In this paper we study the cosmic acceleration for five dynamical dark energy models whose equation of state varies with redshift. The cosmological parameters of these models are constrained by performing a MCMC analysis using mainly gas mass fraction, $f_{gas}$, measurements in two samples of galaxy clusters: one reported by Allen et al. (2004), which consists of $42$ points spanning the redshift range $0.05<z<1.1$, and the other by Hasselfield et al. (2013) from the Atacama Cosmology Telescope survey, which consists of $91$ data points in the redshift range $0.118 < \mathrm{z} < 1.36$. In addition, we perform a joint analysis with the measurements of the Hubble parameter $H(z)$, baryon acoustic oscillations and the cosmic microwave background radiation from WMAP and Planck measurements to estimate the equation of state parameters. We obtained that both $f_{gas}$ samples provide consistent constraints on the cosmological parameters. We found that the $f_{gas}$ data is consistent at the $2\sigma$ confidence level with a cosmic slowing down of the acceleration at late times for most of the parameterizations. The constraints of the joint analysis using WMAP and Planck measurements show that this trend disappears. We have confirmed that the $f_{gas}$ probe provides competitive constraints on the dark energy parameters when a $w(z)$ is assumed.Comment: 21 pages, 8 Tables, 11 Figures, accepted for publication in MNRA

A magnified glance into the dark sector: probing cosmological models with strong lensing in A1689

In this paper we constrain four alternative models to the late cosmic acceleration in the Universe: Chevallier-Polarski-Linder (CPL), interacting dark energy (IDE), Ricci holographic dark energy (HDE), and modified polytropic Cardassian (MPC). Strong lensing (SL) images of background galaxies produced by the galaxy cluster Abell $1689$ are used to test these models. To perform this analysis we modify the LENSTOOL lens modeling code. The value added by this probe is compared with other complementary probes: Type Ia supernovae (SNIa), baryon acoustic oscillations (BAO), and cosmic microwave background (CMB). We found that the CPL constraints obtained of the SL data are consistent with those estimated using the other probes. The IDE constraints are consistent with the complementary bounds only if large errors in the SL measurements are considered. The Ricci HDE and MPC constraints are weak but they are similar to the BAO, SNIa and CMB estimations. We also compute the figure-of-merit as a tool to quantify the goodness of fit of the data. Our results suggest that the SL method provides statistically significant constraints on the CPL parameters but weak for those of the other models. Finally, we show that the use of the SL measurements in galaxy clusters is a promising and powerful technique to constrain cosmological models. The advantage of this method is that cosmological parameters are estimated by modelling the SL features for each underlying cosmology. These estimations could be further improved by SL constraints coming from other galaxy clusters.Comment: 13 pages, 5 figures, accepted for publication in Ap

IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion.

BackgroundStudies from our laboratory and others have shown that cysteine-rich 61 (Cyr61) may be involved in tumor proliferation and invasion. In earlier studies, we demonstrated increased insulin-like growth factor-I (IGF-1) is associated with breast tumor formation and poor clinical outcomes. In our current study we have investigated IGF-1 regulation of Cyr61 and whether targeting IGF-1 could inhibit Cyr61 induced tumor growth and proliferation.MethodsSeveral ATCC derived normal and breast cancer cell lines were used in this study: MDA-MB231, BT474, MCF-7, and SKBR3. We also tested cells stably transfected in our laboratory with active Akt1 (pAkt; SKBR3/AA and MCF-7/AA) and dominant negative Akt1 (SKBR3/DN and MCF-7/DN). In addition, we used MCF-7 cells transfected with full length Cyr61 (CYA). Monolayer cultures treated with IGF-1 were analyzed for Cyr61 expression by RT-PCR and immunohistochemical staining. Migration assays and MTT based proliferation assays were used to determine invasive characteristics in response to IGF-1/Cyr61 activation.ResultsCells with activated Akt have increased levels of Cyr61. Conversely, cells with inactive Akt have decreased levels of Cyr61. IGF-1 treatment increased Cyr61 expression significantly and cells with high level of Cyr61 demonstrate increased invasiveness and proliferation. Cyr61 overexpression and activation led to decrease in E-cadherin and decrease in FOXO1. Inhibition of the PI3K and MAPK pathways resulted in significant decrease in invasiveness and proliferation, most notably in the PI3K pathway inhibited cells.ConclusionThe findings of this study show that IGF-1 upregulates Cyr61 primarily through activation of the Akt-PI3K pathway. IGF-1 induced MAPK plays a partial role. Increase in Cyr61 leads to increase in breast cancer cell growth and invasion. Hence, targeting Cyr61 and associated pathways may offer an opportunity to inhibit IGF-1 mediated Cyr61 induced breast cancer growth and invasion

Structure of lithium catena-poly[3,4-dihydroxopentaborate-1:5-[mu]-oxo]

LiH2B5O9, M(r) = 207.0, monoclinic, P2(1)/a, a = 13.576 (4), b = 9.077 (4), c = 5.543 (3) angstrom, beta = 91.47 (1)degrees, V = 682.8 (4)) angstrom3, Z = 4, D(x) = 2.013 g cm-3, lambda(Mo Kalpha) = 0.7107 angstrom, mu = 2.06 cm F(000) = 408, T = 293 K, R = 0.049 for 1689 independent observed reflections. The structure contains chains of B5O9H2]- anions linked through shared O atoms. In each anionic unit two B3O3 rings, each incorporating two triangular BO3 units, are connected by a shared tetrahedral BO4 unit. The Li atom has four O-atom neighbours arranged in an approximately tetrahedral configuration. The Li polyhedra connect B-O polyanions to form a two-dimensional network. Further connections are provided by hydrogen bonds

Quinstant Dark Energy Predictions for Structure Formation

We explore the predictions of a class of dark energy models, quinstant dark energy, concerning the structure formation in the Universe, both in the linear and non-linear regimes. Quinstant dark energy is considered to be formed by quintessence and a negative cosmological constant. We conclude that these models give good predictions for structure formation in the linear regime, but fail to do so in the non-linear one, for redshifts larger than one.Comment: 9 pages, 14 figures, "Accepted for publication in Astrophysics & Space Science