Testing a dissipative kinetic k-essence model

In this work, we present a study of a purely kinetic k-essence model, characterized basically by a parameter $\alpha$ in presence of a bulk dissipative term, whose relationship between viscous pressure $\Pi$ and energy density $\rho$ of the background follows a polytropic type law $\Pi \propto \rho^{\lambda+1/2}$, where $\lambda$, in principle, is a parameter without restrictions. Analytical solutions for the energy density of the k-essence field are found in two specific cases: $\lambda=1/2$ and $\lambda=(1-\alpha)/2\alpha$, and then we show that these solutions posses the same functional form than the non-viscous counterpart. Finally, both approach are contrasted with observational data from type Ia supernova, and the most recent Hubble parameter measurements, and therefore, the best values for the parameters of the theory are founds.Comment: 9 pages, 5 figures, accepted in EPJ

Testing cosmic acceleration for w(z)w(z) parameterizations using fgasf_{gas} measurements in galaxy clusters

In this paper we study the cosmic acceleration for five dynamical dark energy models whose equation of state varies with redshift. The cosmological parameters of these models are constrained by performing a MCMC analysis using mainly gas mass fraction, $f_{gas}$, measurements in two samples of galaxy clusters: one reported by Allen et al. (2004), which consists of $42$ points spanning the redshift range $0.05<z<1.1$, and the other by Hasselfield et al. (2013) from the Atacama Cosmology Telescope survey, which consists of $91$ data points in the redshift range $0.118 < \mathrm{z} < 1.36$. In addition, we perform a joint analysis with the measurements of the Hubble parameter $H(z)$, baryon acoustic oscillations and the cosmic microwave background radiation from WMAP and Planck measurements to estimate the equation of state parameters. We obtained that both $f_{gas}$ samples provide consistent constraints on the cosmological parameters. We found that the $f_{gas}$ data is consistent at the $2\sigma$ confidence level with a cosmic slowing down of the acceleration at late times for most of the parameterizations. The constraints of the joint analysis using WMAP and Planck measurements show that this trend disappears. We have confirmed that the $f_{gas}$ probe provides competitive constraints on the dark energy parameters when a $w(z)$ is assumed.Comment: 21 pages, 8 Tables, 11 Figures, accepted for publication in MNRA

A magnified glance into the dark sector: probing cosmological models with strong lensing in A1689

In this paper we constrain four alternative models to the late cosmic acceleration in the Universe: Chevallier-Polarski-Linder (CPL), interacting dark energy (IDE), Ricci holographic dark energy (HDE), and modified polytropic Cardassian (MPC). Strong lensing (SL) images of background galaxies produced by the galaxy cluster Abell $1689$ are used to test these models. To perform this analysis we modify the LENSTOOL lens modeling code. The value added by this probe is compared with other complementary probes: Type Ia supernovae (SNIa), baryon acoustic oscillations (BAO), and cosmic microwave background (CMB). We found that the CPL constraints obtained of the SL data are consistent with those estimated using the other probes. The IDE constraints are consistent with the complementary bounds only if large errors in the SL measurements are considered. The Ricci HDE and MPC constraints are weak but they are similar to the BAO, SNIa and CMB estimations. We also compute the figure-of-merit as a tool to quantify the goodness of fit of the data. Our results suggest that the SL method provides statistically significant constraints on the CPL parameters but weak for those of the other models. Finally, we show that the use of the SL measurements in galaxy clusters is a promising and powerful technique to constrain cosmological models. The advantage of this method is that cosmological parameters are estimated by modelling the SL features for each underlying cosmology. These estimations could be further improved by SL constraints coming from other galaxy clusters.Comment: 13 pages, 5 figures, accepted for publication in Ap

IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion.

BackgroundStudies from our laboratory and others have shown that cysteine-rich 61 (Cyr61) may be involved in tumor proliferation and invasion. In earlier studies, we demonstrated increased insulin-like growth factor-I (IGF-1) is associated with breast tumor formation and poor clinical outcomes. In our current study we have investigated IGF-1 regulation of Cyr61 and whether targeting IGF-1 could inhibit Cyr61 induced tumor growth and proliferation.MethodsSeveral ATCC derived normal and breast cancer cell lines were used in this study: MDA-MB231, BT474, MCF-7, and SKBR3. We also tested cells stably transfected in our laboratory with active Akt1 (pAkt; SKBR3/AA and MCF-7/AA) and dominant negative Akt1 (SKBR3/DN and MCF-7/DN). In addition, we used MCF-7 cells transfected with full length Cyr61 (CYA). Monolayer cultures treated with IGF-1 were analyzed for Cyr61 expression by RT-PCR and immunohistochemical staining. Migration assays and MTT based proliferation assays were used to determine invasive characteristics in response to IGF-1/Cyr61 activation.ResultsCells with activated Akt have increased levels of Cyr61. Conversely, cells with inactive Akt have decreased levels of Cyr61. IGF-1 treatment increased Cyr61 expression significantly and cells with high level of Cyr61 demonstrate increased invasiveness and proliferation. Cyr61 overexpression and activation led to decrease in E-cadherin and decrease in FOXO1. Inhibition of the PI3K and MAPK pathways resulted in significant decrease in invasiveness and proliferation, most notably in the PI3K pathway inhibited cells.ConclusionThe findings of this study show that IGF-1 upregulates Cyr61 primarily through activation of the Akt-PI3K pathway. IGF-1 induced MAPK plays a partial role. Increase in Cyr61 leads to increase in breast cancer cell growth and invasion. Hence, targeting Cyr61 and associated pathways may offer an opportunity to inhibit IGF-1 mediated Cyr61 induced breast cancer growth and invasion

Brans-Dicke-type theories and avoidance of the cosmological singularity

We tudy flat Friedmann-Robertson-Walker cosmology in Brans-Dicke-type theories of gravitation with minimal coupling between the scalar field and the matter fields in the Einstein frame (general relativity with an extra scalar field) for arbitrary values of the Brans-Dicke parameter $\omega>-{3/2}$. It is shown that the cosmological singularity occuring in the Einstein frame formulation of this theory is removed in the Jordan frame in the range $-{3/2}<\omega<\leq-{4/3}$. This result is interpreted in the ligth of a viewpoint (first presented in reference gr-qc/9905071) asserting that both Jordan frame and Einstein frame formulations of general relativity are physically equivalent. The implications of the obtained result for string theory are outlined.Comment: 9 pages, LaTeX, no figures. Improved version accepted for publication in PR

Strain self-sensing tailoring in functionalised carbon nanotubes/epoxy nanocomposites in response to electrical resistance change measurement

Carbon nanotubes (CNTs) are inherently multifunctional, conductive and possess piezo-resistive characteristics. Aiming at the multi-functionality of materials, nanocomposites made of epoxy resin with embedded CNTs are a promising solution for strain self-sensing applications. A critical parameter to achieve repeatable and reliable measure is the CNTs dispersion state in the resin. This study investigated the effect of CNTs concentration (0.01 wt% and 0.1 wt%), with different loading of surfactant Triton X-100, (0.0%, 0.2%, 0.5% and 1.0%) on strain sensing in terms of sensitivity and linearity based on electrical resistance data. The CNTs were synthesised directly using an injection floating catalyst chemical vapor deposition (ICCVD) process and their quality was characterised by Raman spectroscopy and scanning electron microscopy. Only the epoxy modfied with 0.1 wt% CNTs exhibited sufficient piezo-resistivity for the resistance measurements, and those with 0.01 wt% CNTs did not show sufficiently measurable conductivity so were excluded in our study, since their CNTs were highly entangled, and conductive network failed to be established. It was observed that, with 0.1 wt% CNTs, adding 0.5% content of the surfactant improved gauge factor. With more content of the surfactant (1.0 %), surprisingly, we observed a drop of gauge factor by the order of two. Therefore, by comparing the conductivity change between 1.0% and 0.5% surfactant, we postulated that the relatively high content surfactant has reached critical micelle concentration, and negatively affects CNTs dispersion state. The research presented in this article shows that moderate content of surfactant could improve piezoresistivity gauge factor while excessive surfactant could cause adverse effect

An assessment of nitrification inhibitors to reduce nitrous oxide emissions from UK agriculture

A trial was conducted consisting of 14 experiments across sites in England of contrasting soil type and annual rainfall to assess the effectiveness of nitrification inhibitors (predominantly dicyandiamide (DCD) but limited assessment also of 3, 4-dimethylpyrazole phosphate (DMPP) and a commercial product containing two pyrazole derivatives) in reducing direct nitrous oxide (N _2 O) emissions from fertilizer nitrogen (N), cattle urine and cattle slurry applications to land. Measurements were also made of the impact on ammonia (NH _3 ) volatilization, nitrate (NO _3 ^− ) leaching, crop yield and crop N offtake. DCD proved to be very effective in reducing direct N _2 O emissions following fertilizer and cattle urine applications, with mean reduction efficiencies of 39, 69 and 70% for ammonium nitrate, urea and cattle urine, respectively. When included with cattle slurry a mean, non-significant reduction of 56% was observed. There were no N _2 O emission reductions observed from the limited assessments of the other nitrification inhibitors. Generally, there were no impacts of the nitrification inhibitors on NH _3 volatilization, NO _3 ^− leaching, crop yield or crop N offtake. Use of DCD could give up to 20% reduction in N _2 O emissions from UK agriculture, but cost-effective delivery mechanisms are required to encourage adoption by the sector. Direct N _2 O emissions from the studied sources were substantially lower than IPCC default values and development of UK country-specific emission factors for use in inventory compilation is warranted

A Doubly Nudged Elastic Band Method for Finding Transition States

A modification of the nudged elastic band (NEB) method is presented that enables stable optimisations to be run using both the limited-memory quasi-Newton (L-BFGS) and slow-response quenched velocity Verlet (SQVV) minimisers. The performance of this new `doubly nudged' DNEB method is analysed in conjunction with both minimisers and compared with previous NEB formulations. We find that the fastest DNEB approach (DNEB/L-BFGS) can be quicker by up to two orders of magnitude. Applications to permutational rearrangements of the seven-atom Lennard-Jones cluster (LJ7) and highly cooperative rearrangements of LJ38 and LJ75 are presented. We also outline an updated algorithm for constructing complicated multi-step pathways using successive DNEB runs.Comment: 13 pages, 8 figures, 2 table