16 research outputs found
Efeitos do uso de órteses na Doença de Charcot-Marie-Tooth: atualização da literatura
A Doença de Charcot-Marie-Tooth (DCMT) é a
neuropatia periférica hereditária mais comum em seres humanos,
apresentando incidência de 1:2.500 pessoas. A fraqueza
distal crural na DCMT provoca inúmeras alterações na
marcha, como, por exemplo, na velocidade, no comprimento,
na largura e cadência dos passos. Vários recursos em reabilitação
têm sido propostos para gerenciar os problemas de
deambulação, dentre eles, destaca-se a utilização de órteses.
O objetivo deste estudo é apresentar e discutir os resultados
de estudos sobre os efeitos da utilização de órteses
nos padrões de marcha na DCMT. Neste estudo foi utilizada
atualização da literatura através das principais bases de
dados nacionais/internacionais (SciELO, LILACS e MEDLINE),
publicados entre os anos de 2006–2012. O tratamento da
DCMT consiste em fisioterapia e utilização de equipamentos
de assistência, visto que ainda não há fármacos ou terapia
gênica capaz de atenuar os danos clínicos e funcionais. Tal
associação busca maximizar a função e melhorar a qualidade
de vida desses pacientes, na tentativa de evitar agravos
adicionais relativos à incapacidade física. A partir de atualização
de literatura é possível concluir que existe consenso
sobre a utilização de órteses nos membros inferiores para
promover a estabilização das articulações do tornozelo e um
padrão de deambulação mais funcional, evitando sinergias
inadequadas de movimento e atenuando o risco de quedas. ________________________________________________________________________________________________ABSTRACT: Charcot-Marie-Tooth (CMT) disease is the
most common hereditary peripheral neuropathy in humans,
presenting incidence of 1:2.500 people. The distal
crural weakness of the CMT causes numerous gait impairment
changes, for example, velocity, length, width
and cadence of the steps. Several rehabilitation resources
have been proposed to manage the walking problems,
among them, the use of orthoses is highlighted.
The objective of this study was to present and discuss
the results of studies on the effects of orthotic uses in
CMT gait patterns. In this study it was used to literature
update through major national/international databases
(SciELO, LILACS and MEDLINE), published between
the years 2006–2012. The CMT treatment consisted
of physical therapy and using of assistive equipment,
since there are no drugs or gene therapy able to attenuate
the clinical and functional damages. This association
seeks to maximize the function and improve life quality
of these patients in an attempt to prevent additional
injuries related to physical disability. From literature update
it is possible to conclude that there is a consensus
on the use of lower limb orthoses to promote the
stabilization of the ankle articulation and a more functional
pattern of walking, avoiding inadequate synergy
of movement and reducing the risk of falls
Repeated Oral Exposure to N ε-Carboxymethyllysine, a Maillard Reaction Product, Alleviates Gut Microbiota Dysbiosis in Colitic Mice
International audienc
Extremity Soft Tissue Sarcoma in Adults
When treating soft tissue sarcomas (STSs) of the extremities, the major therapeutic goals are survival, local tumor control, optimal function, and minimal morbidity. Surgical resection of the primary tumor is the essential component of treatment for virtually all patients. A wide surgical margin is necessary for local tumor control when surgery is used without radiation, i.e., the cut should traverse normal tissue outside the reactive tumor zone. This is because sarcomas tend to infiltrate normal tissue adjacent to the evident lesion. Thus, removal of the gross lesion by a simple excision alone (only a narrow margin) is followed by relatively high rates of local recurrence. Radical resections are associated with a reduction in the local recurrence rate, but they may compromise limb function. The combination of function-sparing surgery and radiation achieves better rates of local control than either treatment alone, for nearly all patients with STSs, although combined treatment can be associated with acute wound complications in some patients and late normal tissue complications in others. Because both surgical and radiation techniques are both critically important for optimizing local control of tumor and functional outcome, it is important to manage these patients in dedicated multispecialty clinics comprised of physicians with expertise in sarcomas, including orthopedic and general oncology surgeons, radiation oncologists, medical oncologists, sarcoma pathologists, and bone and soft tissue diagnostic radiologists. Radiation therapy can be given by external beam radiation (EBRT) or brachytherapy or combination thereof. EBRT can be given either pre-operatively or post-operatively