A novel combination of triple metachronous malignancies of the kidney, oropharynx and prostate. A case report

Synchronous or metachronous malignancies are a rare event, with an incidence rate that increases with age. The present study reports the case of a 70-year-old Caucasian male who was referred to the outpatient office of the Urology Unit, Sapienza University of Rome (Latina, Italy) due to lower urinary tract symptoms. An abdominal ultrasound investigation was performed that demonstrated the presence of a right renal mass. The patient underwent right radical nephrectomy, which resulted in the definitive diagnosis of clear cell type renal cell carcinoma. The patient was eventually diagnosed with triple primary metachronous cancer consisting of renal clear cell carcinoma, prostate adenocarcinoma and squamous cell carcinoma of the oropharynx (palatine tonsil). To the best of our knowledge, this combination of primary neoplasms has not previously been documented

Accurate fitting functions for peculiar velocity spectra in standard and massive-neutrino cosmologies

We estimate the velocity field in a large set of $N$-body simulations including massive neutrino particles, and measure the auto-power spectrum of the velocity divergence field as well as the cross-power spectrum between the cold dark matter density and the velocity divergence. We perform these measurements at four different redshifts and within four different cosmological scenarios, covering a wide range in neutrino masses. We find that the nonlinear correction to the velocity power spectra largely depend on the degree of nonlinear evolution with no specific dependence on the value of neutrino mass. We provide a fitting formula, based on the value of the r.m.s. of the matter fluctuations in spheres of $8h^{-1}$Mpc, describing the nonlinear corrections with 3\% accuracy on scales below $k=0.7\; h$ Mpc$^{-1}$.Comment: 8 pages, 5 figures, accepted by A&A, typos corrected in equation 1

Single photons emitted by nano-crystals optically trapped in a deep parabolic mirror

We investigate the emission of single photons from CdSe/CdS dot-in-rods which are optically trapped in the focus of a deep parabolic mirror. Thanks to this mirror, we are able to image almost the full 4$\pi$ emission pattern of nanometer-sized elementary dipoles and verify the alignment of the rods within the optical trap. From the motional dynamics of the emitters in the trap we infer that the single-photon emission occurs from clusters comprising several emitters. We demonstrate the optical trapping of rod-shaped quantum emitters in a configuration suitable for efficiently coupling an ensemble of linear dipoles with the electromagnetic field in free space.Comment: updated version after review, including supplementary material as appendi

Optical trapping of nanoparticles by full solid-angle focusing

Optical dipole-traps are used in various scientific fields, including classical optics, quantum optics and biophysics. Here, we propose and implement a dipole-trap for nanoparticles that is based on focusing from the full solid angle with a deep parabolic mirror. The key aspect is the generation of a linear-dipole mode which is predicted to provide a tight trapping potential. We demonstrate the trapping of rod-shaped nanoparticles and validate the trapping frequencies to be on the order of the expected ones. The described realization of an optical trap is applicable for various other kinds of solid-state targets. The obtained results demonstrate the feasibility of optical dipole-traps which simultaneously provide high trap stiffness and allow for efficient interaction of light and matter in free space.Comment: revised version accepted for publicatio

New trends of pilgrimage:Religion tourism, authenticity and innovation, development and intercultural dialogue: Notes from the diary of a pilgrim of Santiago

The characteristics of our society are often contradictory. Despite the "liquidity" theorized by Bauman, aspects and practices deeply related (in appearance and/or in substance) with spirituality hold great importance in our days. Among these practices, we found the pilgrimages. In this article we analyse this phenomenon in one of its best-known forms, the religious pilgrimage, in particular that of the Camino de Santiago. Today this forms of \u201ctravelling\u201d, the pilgrimage, is studied as a tourism product and a vehicle of local development, and many studies already analysed the profiles and the motivations of the \u201cnew pilgrims\u201d, as well as their economic impacts. Nevertheless, we felt the necessity to meet directly the pilgrims and share this experience with them without any filter. We became part of them, by addressing their perception toward their overall experience, using a qualitative approach based on direct observation and unstructured interviews. We collected data during a 400 kilometers walk towards Santiago de Compostela, which enabled us to create a clear overview on this specific, increasing phenomenon: a pilgrimage between religion and tourism, authenticity and innovation, local development and intercultural dialogue

Combined laparoscopic pyelolithotomy and endoscopic pyelolithotripsy for staghorn calculi. Long-term follow-up results from a case series

Purpose: Staghorn renal stones are a challenging field in urology. Due to their high recurrence rates, particularly those associated with an infective process, a complete removal is the ultimate goal in their management. We report our experience with a combined approach of laparoscopic pyelolithotomy and endoscopic pyelolithotripsy, the stone clearance rate, and long-term, follow-up outcomes. Methods: From June 2012 to October 2014, nine adult patients with large staghorn renal calculi (mean size, 7.2 cm; range, 6.2–9.0 cm) underwent a combined laparoscopic and endoscopic approach. The technique comprised laparoscopic pyelolithotomy and holmium-YAG laser stone fragmentation with the use of a flexible cystoscope introduced through a 12 mm trocar. Results: The average operative time was 140 min (range, 90–190 min). The mean estimated hemoglobin loss was 0.6 mmol/l (range 0.5–0.7 mmol/l). None of the patients required an open- surgery conversion. The mean hospital stay was 4 days (range, 2–6 days). A computed tomography urogram control at 6 months of follow up did not show any stone recurrence. Conclusions: Laparoscopic pyelolithotomy combined with endoscopic pyelolithotripsy could be a therapeutic option in cases where mini-invasive procedures, that is, extracorporeal shock wave lithotripsy, ureteroscopic lithotripsy, and percutaneous nephrolithotomy (PCNL) have failed. This technique has a high stone-clearance rate (75–100%) comparable with open surgery and PCNL. However, it could be technically demanding and should be performed by skilled laparoscopy surgeons