39 research outputs found
The Role Of Omega-3 Polyunsaturated Fatty Acids In The Treatment Of Patients With Acute Respiratory Distress Syndrome: A Clinical Review
Acute respiratory distress syndrome (ARDS) is defined as the acute onset of noncardiogenic edema and subsequent gas-exchange impairment due to a severe inflammatory process. Recent report on the prognostic value of eicosanoids in patients with ARDS suggests that modulating the inflammatory response through the use of polyunsaturated fatty acids may be a useful strategy for ARDS treatment. The use of enteral diets enriched with eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) has reported promising results, showing an improvement in respiratory variables and haemodynamics. However, the interpretation of the studies is limited by their heterogeneity and methodology and the effect of omega-3 fatty acid-enriched lipid emulsion or enteral diets on patients with ARDS remains unclear. Therefore, the routine use of omega-3 fatty acid-enriched nutrition cannot be recommended and further large, homogeneous, and high-quality clinical trials need to be conducted to clarify the effectiveness of omega-3 polyunsaturated fatty acids
Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration
Pathological conditions affecting skeletal muscle function may lead to irreversible volumetric
muscle loss (VML). Therapeutic approaches involving acellular matrices represent an
emerging and promising strategy to promote regeneration of skeletal muscle following injury.
Here we investigated the ability of three different decellularised skeletal muscle scaffolds to
support muscle regeneration in a xenogeneic immune-competent model of VML, in which
the EDL muscle was surgically resected. All implanted acellular matrices, used to replace
the resected muscles, were able to generate functional artificial muscles by promoting host
myogenic cell migration and differentiation, as well as nervous fibres, vascular networks, and
satellite cell (SC) homing. However, acellular tissue mainly composed of extracellular matrix
(ECM) allowed better myofibre three-dimensional (3D) organization and the restoration of
SC pool, when compared to scaffolds which also preserved muscular cytoskeletal
structures. Finally, we showed that fibroblasts are indispensable to promote efficient
migration and myogenesis by muscle stem cells across the scaffolds in vitro. This data strongly support the use of xenogeneic acellular muscles as device to treat VML conditions in absence of donor cell implementation, as well as in vitro model for studying cell interplay during myogenesis
Neue linguistische Methoden und arbeitstechnische Verfahren in der Erschliessung der Àgyptischen Grammatik
15 pĂĄginas, 1 tabla, 6 figuras.Does diversity beget diversity? Diversity
includes a diversity of concepts because it is linked to
variability in and of life and can be applied to multiple
levels. The connections between multiple levels of
diversity are poorly understood. Here, we investigated
the relationships between genetic, bacterial, and
chemical diversity of the endangered Atlanto-Mediterranean sponge Spongia lamella. These levels of
diversity are intrinsically related to sponge evolution
and could have strong conservation implications. We
used microsatellite markers, denaturing gel gradient
electrophoresis and quantitative polymerase chain
reaction, and high performance liquid chromatography to quantify genetic, bacterial, and chemical
diversity of nine sponge populations. We then used
correlations to test whether these diversity levels
covaried. We found that sponge populations differed
signiïŹcantly in genetic, bacterial, and chemical
diversity. We also found a strong geographic pattern
of increasing genetic, bacterial, and chemical dissimilarity with increasing geographic distance between
populations. However, we failed to detect signiïŹcant
correlations between the three levels of diversity
investigated in our study. Our results suggest that
diversity fails to beget diversity within a single species
and indicates that a diversity of factors regulates a
diversity of diversities, which highlights the complex
nature of the mechanisms behind diversityResearch funded by grants from the Agence Nationale de la
Recherche (ECIMAR), from the Spanish Ministry of Science
and Technology SOLID (CTM2010-17755) and Benthomics
(CTM2010-22218-C02-01) and the BIOCAPITAL project
(MRTN-CT-2004-512301) of the European Union. This is a
contribution of the Consolidated Research Group ââGrupo de
EcologıŽa BentoÂŽnica,ââ SGR2009-655.Peer reviewe
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Knowledge flows and technologies in renewable energies at the regional level in Europe
This study provides a new insight into the impact of knowledge flows for renewable energy (RE) technologies. With patent data for the European regions in the period 2000-10, we observe that RE technologies have more analytical knowledge content than the rest of the technologies. They also seem to benefit highly from both scientific knowledge flows and technological knowledge flows coming from distant places. This pattern is peculiar to the RE field and different from other cutting-edge technologies, and even different from those technologies related to energy generation coming from traditional energy sectors
The Role of Omega-3 Polyunsaturated Fatty Acids in the Treatment of Patients with Acute Respiratory Distress Syndrome: A Clinical Review
Acute respiratory distress syndrome (ARDS) is defined as the acute onset of noncardiogenic edema and subsequent gas-exchange impairment due to a severe inflammatory process. Recent report on the prognostic value of eicosanoids in patients with ARDS suggests that modulating the inflammatory response through the use of polyunsaturated fatty acids may be a useful strategy for ARDS treatment. The use of enteral diets enriched with eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) has reported promising results, showing an improvement in respiratory variables and haemodynamics. However, the interpretation of the studies is limited by their heterogeneity and methodology and the effect of Ï-3 fatty acid-enriched lipid emulsion or enteral diets on patients with ARDS remains unclear. Therefore, the routine use of Ï-3 fatty acid-enriched nutrition cannot be recommended and further large, homogeneous, and high-quality clinical trials need to be conducted to clarify the effectiveness of Ï-3 polyunsaturated fatty acids
The Role Of Omega-3 Polyunsaturated Fatty Acids In The Treatment Of Patients With Acute Respiratory Distress Syndrome: A Clinical Review
Acute respiratory distress syndrome (ARDS) is defined as the acute onset of noncardiogenic edema and subsequent gas-exchange impairment due to a severe inflammatory process. Recent report on the prognostic value of eicosanoids in patients with ARDS suggests that modulating the inflammatory response through the use of polyunsaturated fatty acids may be a useful strategy for ARDS treatment. The use of enteral diets enriched with eicosapentaenoic acid (EPA) and gamma-linolenic acid (GLA) has reported promising results, showing an improvement in respiratory variables and haemodynamics. However, the interpretation of the studies is limited by their heterogeneity and methodology and the effect of omega-3 fatty acid-enriched lipid emulsion or enteral diets on patients with ARDS remains unclear. Therefore, the routine use of omega-3 fatty acid-enriched nutrition cannot be recommended and further large, homogeneous, and high-quality clinical trials need to be conducted to clarify the effectiveness of omega-3 polyunsaturated fatty acids