Problem Based Learning

In this current work, I am proposing a general close examination of Problem Based Learning as a student centered educational method in which a problem constitutes  the starting point of the learning process. Such a method provides students with the suitable knowledge for problem solving and presents numerous and significant differences compared to traditional education.In particular, I analyze the theoretic aspects of problem learning by tracing a history and presenting its structure, clarifying the role of the tutor in the various phases of the learning process. The method has found a wide diffusion since the beginning of the 70s and numerous studies have confirmed the advantages. The effectiveness of PBL is construable and is based on principles of constructivism and cognitivism

Dissecting the Workforce and Workplace for Clinical Endocrinology, and the Work of Endocrinologists Early in Their Careers

[Excerpt] No national mechanism is in place for an informed, penetrating, and systematic assessment of the physician workforce such as that achieved by the National Science Foundation (NSF) for the periodic evaluation of the nation’s scientists and engineers. Likewise, knowledge of the workforce for clinical research is enigmatic and fragmentary despite the serial recommendations of “blue-ribbon” panels to establish a protocol for the recurrent assessment of clinical investigators early in their careers. Failure to adopt a national system for producing timely, high-quality data on the professional activities of physicians limits the application of improvement tools for advancing clinical investigation and ultimately improving clinical practice. The present study was designed as a pilot project to test the feasibility of using Web-based surveys to estimate the administrative, clinical, didactic, and research work of subspecialty physicians employed in academic, clinical, federal, and pharmaceutical workplaces. Physician members of The Endocrine Society (TES) were used as surrogate prototypes of a subspecialty workforce because of their manageable number and investigative tradition. The results establish that Web-based surveys provide a tool to assess the activities of a decentralized workforce employed in disparate workplaces and underscore the value of focusing on physician work within the context of particular workplaces within a subspecialty. Our report also provides a new and timely snapshot of the amount and types of research performed by clinically trained endocrinologists and offers an evidenced-based framework for improving the investigative workforce in this medical subspecialty

Analysis of Concussion Experiences and Awareness in College Athletics at Bryant and Beyond

The purpose of this thesis is to examine concussion experiences, awareness and education through a literature review and study of Bryant students. The study assessed concussion awareness and experiences through a questionnaire sent out to club and division 1 athletes at Bryant through email and social media channels. The study yielded 98 responses, but after filtering out responses with insufficient information 62 usable responses remained. These responses consisted of 62% female and 34% male athletes on 13 different teams. Of the 62 participants, 34 (roughly half) reported being diagnosed with a concussion in their lifetime, and 18 athletes reported having more than one concussion. The athletes reported experiencing a variety of symptoms, with headache being the most prevalent, as all diagnosed athletes reported experiencing this symptom. Bryant athletes scored well on a CDC awareness quiz with an average score of a 98%. Overall, Bryant and other student athletes can use more education on distinguishing between concussions and more severe brain injuries that would require hospitalization, concussion diagnosing, and assessing situations in which concussions can occur. Though reporting behaviors are relatively good, more education may help improve decision making and safety for athletes. A majority of the athletes at Bryant scored well on the awareness quiz and felt relatively comfortable reporting their concussions to their coaches, but they also indicated that their teammates could benefit from more concussion education regardless. Therefore, it is safe to conclude that Bryant athletes, along with many other college athletes, could benefit from more concussion education

Modeling bivariate longitudinal hormone profiles by hierarchical state space models

The hypothalamic-pituitary-adrenal (HPA) axis is crucial in coping with stress and maintaining homeostasis. Hormones produced by the HPA axis exhibit both complex univariate longitudinal profiles and complex relationships among different hormones. Consequently, modeling these multivariate longitudinal hormone profiles is a challenging task. In this paper, we propose a bivariate hierarchical state space model, in which each hormone profile is modeled by a hierarchical state space model, with both population-average and subject-specific components. The bivariate model is constructed by concatenating the univariate models based on the hypothesized relationship. Because of the flexible framework of state space form, the resultant models not only can handle complex individual profiles, but also can incorporate complex relationships between two hormones, including both concurrent and feedback relationship. Estimation and inference are based on marginal likelihood and posterior means and variances. Computationally efficient Kalman filtering and smoothing algorithms are used for implementation. Application of the proposed method to a study of chronic fatigue syndrome and fibromyalgia reveals that the relationships between adrenocorticotropic hormone and cortisol in the patient group are weaker than in healthy controls

Te De AH!

Te De AH! es un documental que muestra la experiencia de lo que es vivir con trastorno de déficit de atención, planteando la problemática de la falta de diagnóstico en la población y la gran desinformación que hay sobre el tema. Siendo así un recurso para las personas con TDAH para buscar ayuda y conocerse más a ellos mismos.Para acceder al documental, hacer clic en "Enlace externo".Facultad de Arte

Reciprocal regulation of metabolic and signaling pathways

<p>Abstract</p> <p>Background</p> <p>By studying genome-wide expression patterns in healthy and diseased tissues across a wide range of pathophysiological conditions, DNA microarrays have revealed unique insights into complex diseases. However, the high-dimensionality of microarray data makes interpretation of heterogeneous gene expression studies inherently difficult.</p> <p>Results</p> <p>Using a large-scale analysis of more than 40 microarray studies encompassing ~2400 mammalian tissue samples, we identified a common theme across heterogeneous microarray studies evident by a robust genome-wide inverse regulation of metabolic and cell signaling pathways: We found that upregulation of cell signaling pathways was invariably accompanied by downregulation of cell metabolic transcriptional activity (and vice versa). Several findings suggest that this characteristic gene expression pattern represents a new principle of mammalian transcriptional regulation. First, this coordinated transcriptional pattern occurred in a wide variety of physiological and pathophysiological conditions and was identified across all 20 human and animal tissue types examined. Second, the differences in metabolic gene expression predicted the magnitude of differences for signaling and all other pathways, i.e. tissue samples with similar expression levels of metabolic transcripts did not show any differences in gene expression for all other pathways. Third, this transcriptional pattern predicted a profound effect on the proteome, evident by differences in structure, stability and post-translational modifications of proteins belonging to signaling and metabolic pathways, respectively.</p> <p>Conclusions</p> <p>Our data suggest that in a wide range of physiological and pathophysiological conditions, gene expression changes exhibit a recurring pattern along a transcriptional axis, characterized by an inverse regulation of major metabolic and cell signaling pathways. Given its widespread occurrence and its predicted effects on protein structure, protein stability and post-translational modifications, we propose a new principle for transcriptional regulation in mammalian biology.</p

The Relation of Thyroid Function to Components of the Metabolic Syndrome in Korean Men and Women

This study was to assess the relation of thyroid dysfunction to metabolic syndrome (MetS) at an earlier stage in Korean population. Metabolic parameters such as body composition, blood pressure (BP), fasting glucose, total cholesterol, triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), thyroid-stimulating hormone (TSH) and free thyroxine 4 (fT4) were measured. During a mean follow-up of 3 yr, 5,998 Koreans ages over 18 yr were assessed. There were 694 cases of MetS at follow-up. The mean age of the subjects was 45.6 ± 9.5 yr. Mean level of TSH was 2.02 ± 1.50 mIU/L, mean level of fT4 was 1.23 ± 0.20 ρM/L. At baseline, TSH levels and fT4 levels were associated to waist circumference, BP, glucose and lipids in the subjects. Increase in systolic blood pressure, diastolic blood pressure (DBP), total cholesterol and TG were significantly associated with changes in TSH levels after adjustment. Changes in DBP, TG, HDL-C and fasting glucose were significantly associated with changes in fT4 levels after adjustment. Increase in TSH levels even after further controlling for baseline TSH level predicted the MetS over the study period. In conclusion, there is a relationship between thyroid function and cardiovascular risk factors, such as BP, total cholesterol, TG, HDL-C and fasting glucose. Also, higher levels of TSH may predict the MetS in Korean