7 research outputs found
Total synthesis of rapamycin.
For over 30 years, rapamycin has generated a sustained and intense interest from the scientific community as a result of its exceptional pharmacological properties and challenging structural features. In addition to its well known therapeutic value as a potent immunosuppressive agent, rapamycin and its derivatives have recently gained prominence for the treatment of a wide variety of other human malignancies. Herein we disclose full details of our extensive investigation into the synthesis of rapamycin that culminated in a new and convergent preparation featuring a macro-etherification/catechol-templating strategy for construction of the macrocyclic core of this natural product
Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways
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Space Telescope and Optical Reverberation Mapping Project. VIII. Time Variability of Emission and Absorption in NGC 5548 Based on Modeling the Ultraviolet Spectrum
We model the ultraviolet spectra of the Seyfert 1 galaxy NGC 5548 obtained with the Hubble Space Telescope during the 6 month reverberation mapping campaign in 2014. Our model of the emission from NGC 5548 corrects for overlying absorption and deblends the individual emission lines. Using the modeled spectra, we measure the response to continuum variations for the deblended and absorption-corrected individual broad emission lines, the velocity-dependent profiles of Ly and C iv, and the narrow and broad intrinsic absorption features. We find that the time lags for the corrected emission lines are comparable to those for the original data. The velocity-binned lag profiles of Ly and C iv have a double-peaked structure indicative of a truncated Keplerian disk. The narrow absorption lines show a delayed response to continuum variations corresponding to recombination in gas with a density of ∼105 cm-3. The high-ionization narrow absorption lines decorrelate from continuum variations during the same period as the broad emission lines. Analyzing the response of these absorption lines during this period shows that the ionizing flux is diminished in strength relative to the far-ultraviolet continuum. The broad absorption lines associated with the X-ray obscurer decrease in strength during this same time interval. The appearance of X-ray obscuration in ∼2012 corresponds with an increase in the luminosity of NGC 5548 following an extended low state. We suggest that the obscurer is a disk wind triggered by the brightening of NGC 5548 following the decrease in size of the broad-line region during the preceding low-luminosity state
Space Telescope and Optical Reverberation Mapping Project. VIII. Time Variability of Emission and Absorption in NGC 5548 Based on Modeling the Ultraviolet Spectrum
We model the ultraviolet spectra of the Seyfert 1 galaxy NGC 5548 obtained with the Hubble Space Telescope during the 6 month reverberation mapping campaign in 2014. Our model of the emission from NGC 5548 corrects for overlying absorption and deblends the individual emission lines. Using the modeled spectra, we measure the response to continuum variations for the deblended and absorption-corrected individual broad emission lines, the velocity-dependent profiles of Lyα and C iv, and the narrow and broad intrinsic absorption features. We find that the time lags for the corrected emission lines are comparable to those for the original data. The velocity-binned lag profiles of Lyα and C iv have a double-peaked structure indicative of a truncated Keplerian disk. The narrow absorption lines show a delayed response to continuum variations corresponding to recombination in gas with a density of ~105 cm−3. The high-ionization narrow absorption lines decorrelate from continuum variations during the same period as the broad emission lines. Analyzing the response of these absorption lines during this period shows that the ionizing flux is diminished in strength relative to the far-ultraviolet continuum. The broad absorption lines associated with the X-ray obscurer decrease in strength during this same time interval. The appearance of X-ray obscuration in ~2012 corresponds with an increase in the luminosity of NGC 5548 following an extended low state. We suggest that the obscurer is a disk wind triggered by the brightening of NGC 5548 following the decrease in size of the broad-line region during the preceding low-luminosity state
Active galactic nuclei: what’s in a name?
Active Galactic Nuclei (AGN) are energetic astrophysical sources powered by
accretion onto supermassive black holes in galaxies, and present unique
observational signatures that cover the full electromagnetic spectrum over more
than twenty orders of magnitude in frequency. The rich phenomenology of AGN has
resulted in a large number of different "flavours" in the literature that now
comprise a complex and confusing AGN "zoo". It is increasingly clear that these
classifications are only partially related to intrinsic differences between
AGN, and primarily reflect variations in a relatively small number of
astrophysical parameters as well the method by which each class of AGN is
selected. Taken together, observations in different electromagnetic bands as
well as variations over time provide complementary windows on the physics of
different sub-structures in the AGN. In this review, we present an overview of
AGN multi-wavelength properties with the aim of painting their "big picture"
through observations in each electromagnetic band from radio to gamma-rays as
well as AGN variability. We address what we can learn from each observational
method, the impact of selection effects, the physics behind the emission at
each wavelength, and the potential for future studies. To conclude we use these
observations to piece together the basic architecture of AGN, discuss our
current understanding of unification models, and highlight some open questions
that present opportunities for future observational and theoretical progress.Comment: Accepted for publication in Astronomy & Astrophysics Review, 56
pages, 25 figure