Fe Ka line emission from the Arches cluster region - evidence for ongoing particle bombardment?

We present the results of eight years of XMM-Newton observations of the region surrounding the Arches cluster in the Galactic Center. We study the spatial distribution and temporal behaviour of the Fe-Ka line emission with the objective of identifying the likely source of the excitation. We investigate the variability of the 6.4-keV line emission of four clouds through spectral fitting of the EPIC MOS data with the use of a modelled background, which avoids many of the systematics inherent in local background subtraction. We also employ spectral stacking of both EPIC PN and MOS data to search for evidence of an Fe-K edge feature imprinted on the underlying X-ray continuum. The lightcurves of the Fe-Ka line from three bright molecular knots close to the Arches cluster are found to be constant over the 8-year observation window. West of the cluster, however, we found a bright cloud exhibiting the fastest Fe-Ka variability yet seen in a molecular cloud in the Galactic Center region. The time-averaged spectra of the molecular clouds reveal no convincing evidence of the 7.1-keV edge feature. The EW of the 6.4-keV line emitted by the clouds near the cluster is found to be ~1.0 keV. The observed Fe-Ka line flux and the high EW suggest the fluorescence has a photoionization origin, although excitation by cosmic-ray particles is not specifically excluded. For the three clouds nearest to the cluster, an identification of the source of photo-ionizing photons with an earlier outburst of Sgr A* is however at best tentative. The hardness of the nonthermal component associated with the 6.4-keV line emission might be best explained in terms of bombardment by cosmic-ray particles from the Arches cluster itself. The relatively short-timescale variability seen in the 6.4-keV line emission from the cloud to the West of the cluster is most likely the result of illumination by a nearby transient X-ray source.Comment: 13 pages, 6 figures, accepted for publication in Astronomy and Astrophysic

Determinants of the population growth of the West Nile virus mosquito vector Culex pipiens in a repeatedly affected area in Italy

Background The recent spread of West Nile Virus in temperate countries has raised concern. Predicting the likelihood of transmission is crucial to ascertain the threat to Public and Veterinary Health. However, accurate models of West Nile Virus (WNV) expansion in Europe may be hampered by limited understanding of the population dynamics of their primary mosquito vectors and their response to environmental changes.<p></p> Methods We used data collected in north-eastern Italy (2009–2011) to analyze the determinants of the population growth rate of the primary WNV vector Culex pipiens. A series of alternative growth models were fitted to longitudinal data on mosquito abundance to evaluate the strength of evidence for regulation by intrinsic density-dependent and/or extrinsic environmental factors. Model-averaging algorithms were then used to estimate the relative importance of intrinsic and extrinsic variables in describing the variations of per-capita growth rates.<p></p> Results Results indicate a much greater contribution of density-dependence in regulating vector population growth rates than of any environmental factor on its own. Analysis of an average model of Cx. pipiens growth revealed that the most significant predictors of their population dynamics was the length of daylight, estimated population size and temperature conditions in the 15 day period prior to sampling. Other extrinsic variables (including measures of precipitation, number of rainy days, and humidity) had only a minor influence on Cx. pipiens growth rates.<p></p> Conclusions These results indicate the need to incorporate density dependence in combination with key environmental factors for robust prediction of Cx. pipiens population expansion and WNV transmission risk. We hypothesize that detailed analysis of the determinants of mosquito vector growth rate as conducted here can help identify when and where an increase in vector population size and associated WNV transmission risk should be expected.<p></p&gt

Automorphisms of the affine SU(3) fusion rules

We classify the automorphisms of the (chiral) level-k affine SU(3) fusion rules, for any value of k, by looking for all permutations that commute with the modular matrices S and T. This can be done by using the arithmetic of the cyclotomic extensions where the problem is naturally posed. When k is divisible by 3, the automorphism group (Z_2) is generated by the charge conjugation C. If k is not divisible by 3, the automorphism group (Z_2 x Z_2) is generated by C and the Altsch\"uler--Lacki--Zaugg automorphism. Although the combinatorial analysis can become more involved, the techniques used here for SU(3) can be applied to other algebras.Comment: 21 pages, plain TeX, DIAS-STP-92-4

Effectiveness of the spot-on combination of moxidectin and imidacloprid (Advocate®) in the treatment of ocular thelaziosis by Thelazia callipaeda in naturally infected cats

Background: The present study evaluated the therapeutic effectiveness of moxidectin 1.0% (w/v) and imidacloprid 10% (w/v) (Advocate® spot-on solution for cats, Bayer Animal Health) against natural infections with the eyeworm Thelazia callipaeda in cats. This study was conducted as a GCP, negative-controlled, blinded and randomised field study in privately owned cats living in an area in southern Italy where T. callipaeda is enzootic. Methods: The study was carried out in 30 cats (19 females and 11 males, aged from 8 months to 5 years, weighing 1.2-5.2 kg) of different breeds, naturally infected by T. callipaeda. At study inclusion (Day 0), animals were physically examined and the infection level was assessed by examination of both eyes for clinical score and live adult T. callipaeda count. Each cat was weighed and randomly assigned to one of the treatment groups (G1: Advocate, G2: untreated control). Clinical assessments and T. callipaeda adult counts were performed on Day 14. At the study completion visit on Day 28, clinical assessments and counts of T. callipaeda adults and larvae were performed. All cats were daily observed by their owners and general health conditions were recorded during the entire period of the study. Results: The primary effectiveness variable was the percentage of animals in G1 group (Advocate) showing a complete elimination (parasitological cure) of adult eye worms at Day 14 and Day 28. The effectiveness of the treatment in the G1 group was 93.3 and 100% at Day 14 and Day 28, respectively, when compared to group G2. Total worm count reduction from both eyes for Advocate was 96.3% on Day 14 and 100% on Day 28. Clinical data were confirmed by the examination of conjunctival pouch flushing. An overall reduction in the number of cats with lacrimation and conjunctivitis was observed following treatment despite the fact that in a few cats treated with Advocate clinical signs persisted due to the chronic nature of the disease. Conclusions: Based on the results of the present trial, a single dose of Advocate was found to be safe and highly effective in the treatment of natural T. callipaeda infection in cats

Benefits of 8 weeks of High Intensity Training in healthy women: the Trion project

Aim High-intensity training (HIT) has recently been shown to be a suitable alternative time-saving strategy to improve athletic performance, cardiovascular fitness and muscle metabolism1. Nevertheless, women have rarely participated in studies investigating the efficacy of HIT2. Therefore, the aim of this study was to evaluate in moderately active women the effectiveness of an HIT intervention performed on a new device called Trion. Methods Before and after 8 weeks of HIT (3 time/week, 7reps x 30sec all-out interspersed with 2 min of active rest), in 35 healthy women volunteers (22.5±3.7 yy; BMI: 21.2±2.6), we measured maximal oxygen uptake (V’O2max), ventilatory threshold (VT), anaerobic performance, muscle structure, body composition, hematochemical (CHOLtot) and blood pressure profile at rest. The HIT workout was performed running on non-motorized curve treadmill and cycling on an competition bike mounted on an electromagnetic roller. Results Absolute and relative V’O2max significantly increased by 10% (p<.05); maximal power and power@VT increased by 7.2% and 6.3 % (p<.05), respectively; peak anaerobic performance significantly increased by 10% (p<.05). Large significant differences (p<.05) were identified for vastus lateralis thickness and pennation angle, +4.9% and +10.1%, respectively. Fat mass and CHOLtot decreased by 3.9% and 5.7% (p<.05), respectively. Conclusions Our results confirm the feasibility and effectiveness of HIT to improve exercise performance and health related parameters: HIT performed on Trion device was absolutely safe and well tolerated by the subjects. As confirmed in previous studies, our findings shows that exercise intensity, rather than duration, is the key factor in determining functional benefits. References 1Weston M, Effects of Low-Volume High-Intensity-Interval-Training (HIT) on Fitness in Adults: A Meta-Analysis of Controlled and Non-Controlled Trials Sports Med. 2014; 44(7): 1005–1017. 2Batacan, RB Jr. Effects of high-intensity-interval-training on cardiometabolic health: a systematic review and meta-analysis of intervention studies. Br J Sports Med. 2017 Mar;51(6):494-503

Traditional vs non-motorized curve treadmill: differences in energetic requirements

Previous studies suggest that exercise performed on curve surface treadmill (CT) can increase energy expenditure more than exercise performed on a traditional motorized treadmill (MT). However, to date, there are no data about energy cost that confirm this hypothesis. Thus, the purpose of the study is to analyze the physiological requirements of walking and running on a CT as compared to a traditional MT. 26 subjects (11M + 15W) (24.1±3.4yy; 64.7±11.2kg; 171.1±8.6cm) performed preferred walking speed test and running ramp test to exhaustion on both treadmill in two separated sessions. The gross energy cost of walking (Cw) is greater (p<.05) in CT than in MT (3.79±0.35 j/m/kg, 2.43±0.38 j/m/kg, respectively). The gross energy cost of running (Cr) is greater (p<.05) in CT than in MT (5.05±1.67 j/m/kg, 4.09±0.70 j/m/kg, respectively). Moreover, MT allows to reach higher speeds than CT (MT:15.5±1.7 km/h, CT:13.9±1.4 km/h, p<.05) with lower peak blood lactate concentrations (MT: 8.98±2.43 mmol/L, CT: 10.75±2.76 mmol/L, p<.05). Our data confirm that i) the Cw, matched for speed, is greater in CT than MT; ii) the Cr, analyzed during incremental ramp test, is greater in CT than MT; iii) during the ramp test, for the same metabolic load, the mechanical load is lower in the CT compared to MT. The increased physical effort is due to the greater frictional characteristics and force generation requirements inherent with the use of a CT

The X-ray lightcurve of Sgr A* over the past 150 years inferred from Fe-Ka line reverberation in Galactic Centre molecular clouds

We examine the temporal and spectral properties of nine Fe-Ka bright molecular clouds within about 30 pc of Sgr A*, in order to understand and constrain the primary energising source of the Fe fluorescence. Significant Fe-Ka variability was detected, with a spatial and temporal pattern consistent with that reported in previous studies. The main breakthrough that sets our paper apart from earlier contributions on this topic is the direct measurement of the column density and the Fe abundance of the MCs in our sample. We used the EW measurements to infer the average Fe abundance within the clouds to be 1.6$\pm$0.1 times solar. The cloud column densities derived from the spectral analysis were typically of the order of 10$^{23}$ cm$^{-2}$, which is significantly higher than previous estimates. This in turn has a significant impact on the inferred geometry and time delays within the cloud system. Past X-ray activity of Sgr A* is the most likely source of ionisation within the molecular clouds in the innermost 30 pc of the Galaxy. In this scenario, the X-ray luminosity required to excite these reflection nebulae is of the order of 10$^{37}-10^{38}$ erg s$^{-1}$, significantly lower than that estimated for the Sgr B2 molecular cloud. Moreover, the inferred Sgr A* lightcurve over the past 150 years shows a long-term downwards trend punctuated by occasional counter-trend brightening episodes of at least 5 years duration. Finally, we found that contributions to the Fe fluorescence by X-ray transient binaries and cosmic-ray bombardment are very likely, and suggest possible ways to study this latter phenomenon in the near future.Comment: 23 pages, 14 figures, accepted for publication in Astronomy & Astrophysic