Hematocolpos: An unappreciated diagnosis of hymen imperforation

peer reviewedThe imperforation of the hymen is a relatively rare congenital malformation. It usually manifests itself in adolescence by a hematocolpos. Hematocolpos is the vaginal retention of menstrual blood at puberty. It results clinically in painful amenorrhea and more rarely in a pelvic mass syndrome. The diagnosis is easy, it is primarily clinical. Pelvic ultrasound and nuclear magnetic resonance are the complementary examinations to be performed as a preoperative assessment and to detect any associated genito-urinary malformations

Can students with special educational needs overcome the “success” expectations?

International audienceThe present study examines the poor fit between the idea of school meritocracy and the successful inclusion of students with special educational needs (SEN). Because students with SEN are assigned negative stereotypes related to suffering, failure, and difficulty regarding their school achievement, we argue that, if they succeed at levels comparable to those of regular students, they may experience backlash, a sanction for challenging the status quo. The results of two studies show that backlash can manifest itself in the form of lower assigned competence to students with special educational needs who succeed. More precisely, across a pilot and a main study, our findings indicate that while performing as well as students without special educational needs, the perceived competence of students with special edu- cational needs was evaluated as lower by participants (pre- and in-service teachers), particularly when these students benefitted from an accommodation perceived as “unfair”. Due to its potential role in justifying inequities within educational con- texts, the backlash effect is discussed as an ideological barrier to the inclusion of students with special educational needs

Interaction of hydantoin with solar wind minority ions: O6+ and He2+

International audienceThe laboratory study of prebiotic molecules interacting with solar wind ions is essential to understand their role in the emergence of life in the complex context of astrochemistry of circumstellar environments. In this work, we present the first study of the interaction of hydantoin (C 3 N 2 O 2 H 4 , 100 amu) with Solar wind low energy multiply charged ions: O 6+ at 30 keV and He 2+ at 8 keV. The fragmentation mass spectra as well as correlation maps resulting from the collision are presented and discussed in this paper. Prompt and delayed dissosiation from metastable states of the ionized molelcule have been observed and corresponding life times mesured. Experimental results are completed by DFT numerical calculations of the energy and structures of the initial state of the molecule (z = 0,1,2,3) that show that the molecule can only support 2 charges before spontaneously dissociate. Calculations also demonstrate that the hydantoin's ring opens after double ionisation of the molecule wich may enhance its reactivity in the context of biological molecule formation in crimcum stellar environnement. For the major experimentally observed fragmentation pathways (like 44 amu / 56 amu dissociation), Internal Reaction Coordinate calculation was perfomed pointing out the important role of proton transfert in the fragmentation processes

Installation of a borehole vertical array in the Var valley, Nice, France

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Installation d’un forage vertical dans la basse vallée du Var, Nice, France

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Electron-induced ionization and cationic fragmentations of the isolated molecule of 2,4-imidazolidinedione (Hydantoin) : Study of the relaxing paths thresholds.

International audienceIn this work, ionization and fragmentation of the prebiotic molecule Hydantoin by electron impact was investigated in our new experimental set-up. Scanning of the incident electron energy make possible the determination of appearance thresholds of the parent molecule i.e. vertical ionization potential found in good agreement with previous data but also dissociation thresholds for the main fragmentation patterns. In parallel, thanks to quantum chemistry calculations, reaction schemes compatible with experimental results are give

Clinical, molecular, and radiomic profile of gliomas with FGFR3-TACC3 fusions

International audienceAbstract Background Actionable fibroblast growth factor receptor 3 (FGFR3)–transforming acidic coiled-coil protein 3 fusions (F3T3) are found in approximately 3% of gliomas, but their characteristics and prognostic significance are still poorly defined. Our goal was to characterize the clinical, radiological, and molecular profile of F3T3 positive diffuse gliomas. Methods We screened F3T3 fusion by real-time (RT)-PCR and FGFR3 immunohistochemistry in a large series of gliomas, characterized for main genetic alterations, histology, and clinical evolution. We performed a radiological and radiomic case control study, using an exploratory and a validation cohort. Results We screened 1162 diffuse gliomas (951 unselected cases and 211 preselected for FGFR3 protein immunopositivity), identifying 80 F3T3 positive gliomas. F3T3 was mutually exclusive with IDH mutation (P < 0.001) and EGFR amplification (P = 0.01), defining a distinct molecular cluster associated with CDK4 (P = 0.04) and MDM2 amplification (P = 0.03). F3T3 fusion was associated with longer survival for the whole series and for glioblastomas (median overall survival was 31.1 vs 19.9 mo, P = 0.02) and was an independent predictor of better outcome on multivariate analysis. F3T3 positive gliomas had specific MRI features, affecting preferentially insula and temporal lobe, and with poorly defined tumor margins. F3T3 fusion was correctly predicted by radiomics analysis on both the exploratory (area under the curve [AUC] = 0.87) and the validation MRI (AUC = 0.75) cohort. Using Cox proportional hazards models, radiomics predicted survival with a high C-index (0.75, SD 0.04), while the model combining clinical, genetic, and radiomic data showed the highest C-index (0.81, SD 0.04). Conclusion F3T3 positive gliomas have distinct molecular and radiological features, and better outcome

Recommandations sur les alimentations standard et thérapeutiques chez l’adulte en établissements de santé

International audienceObjectifsL’alimentation à l’hôpital est soumise à de multiples contraintes de fabrication, organisationnelle, sanitaire, écologique, qui influent sur le plateau repas proposé au patient. L’addition d’un ou plusieurs régimes peut ajouter à la complexité et contribuer à sa non-consommation et augmente les risques de dénutrition. L’élaboration de recommandations sur l’alimentation et les régimes à l’hôpital est d’un enjeu majeur.MéthodesUn groupe de pilotage constitué à parité par des médecins et diététiciens de l’Association Française des Diététiciens Nutritionnistes (AFDN) et de la Société Francophone de Nutrition Clinique et Métabolisme (SFNCM) a été constitué pour élaborer des propositions de recommandations, basées sur les résultats d’une enquête nationale sur les régimes à l’hôpital et sur les données de la littérature. Vingt-trois propositions de recommandations ont alors été soumises à 50 experts nationaux, selon la méthode DELPHI définie par la Haute Autorité de Santé d’élaboration de consensus formalisé d’experts.RésultatsCes vingt-trois recommandations ont été jugées appropriées et validées par un accord fort après trois tours de vote, après modifications et argumentations. Elles visent à définir chez l’adulte : 1-le vocabulaire lié aux alimentations/régimes à l’hôpital, 2-l’offre alimentaire (quantitative et qualitative), 3-la prescription nutritionnelle, 4-les modes alimentaires et adaptations aux patients, 5-délimiter les alimentations restreintes afin de réduire les régimes inutiles et sans preuve scientifique, 6-montrer l’importance de la place d’une alimentation spécifiquement adaptée aux patients dénutris et à risque de dénutrition.ConclusionCes recommandations devraient permettre à toutes les équipes de restauration et de soin, de rationnaliser l’offre alimentaire et les prescriptions d’alimentations thérapeutiques et de focaliser leur objectif sur la qualité d’une offre alimentaire adaptée aux besoins et au plaisir du patient