8 research outputs found
Robust Sum-Rate Maximization in Transmissive RMS Transceiver-Enabled SWIPT Networks
In this paper, we propose a state-of-the-art downlink communication
transceiver design for transmissive reconfigurable metasurface (RMS)-enabled
simultaneous wireless information and power transfer (SWIPT) networks.
Specifically, a feed antenna is deployed in the transmissive RMS-based
transceiver, which can be used to implement beamforming. According to the
relationship between wavelength and propagation distance, the spatial
propagation models of plane and spherical waves are built. Then, in the case of
imperfect channel state information (CSI), we formulate a robust system
sum-rate maximization problem that jointly optimizes RMS transmissive
coefficient, transmit power allocation, and power splitting ratio design while
taking account of the non-linear energy harvesting model and outage probability
criterion. Since the coupling of optimization variables, the whole optimization
problem is non-convex and cannot be solved directly. Therefore, the alternating
optimization (AO) framework is implemented to decompose the non-convex original
problem. In detail, the whole problem is divided into three sub-problems to
solve. For the non-convexity of the objective function, successive convex
approximation (SCA) is used to transform it, and penalty function method and
difference-of-convex (DC) programming are applied to deal with the non-convex
constraints. Finally, we alternately solve the three sub-problems until the
entire optimization problem converges. Numerical results show that our proposed
algorithm has convergence and better performance than other benchmark
algorithms
Laser-ablated photonic microcavities for exciton and electron transport manipulation in organic dyes
Localization of Large-Scale Wireless Sensor Networks Using Niching Particle Swarm Optimization and Reliable Anchor Selection
Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function
Inflammatory liver diseases are a major cause of morbidity and mortality worldwide; however, underlying mechanisms are incompletely understood. Here we show that deleting the focal adhesion protein Kindlin-2 expression in hepatocytes using the Alb-Cre transgenic mice causes a severe inflammation, resulting in premature death. Kindlin-2 loss accelerates hepatocyte apoptosis with subsequent compensatory cell proliferation and accumulation of the collagenous extracellular matrix, leading to massive liver fibrosis and dysfunction. Mechanistically, Kindlin-2 loss abnormally activates the tumor necrosis factor (TNF) pathway. Blocking activation of the TNF signaling pathway by deleting TNF receptor or deletion of Caspase 8 expression in hepatocytes essentially restores liver function and prevents premature death caused by Kindlin-2 loss. Finally, of translational significance, adeno-associated virus mediated overexpression of Kindlin-2 in hepatocytes attenuates the D-galactosamine and lipopolysaccharide-induced liver injury and death in mice. Collectively, we establish that Kindlin-2 acts as a novel intrinsic inhibitor of the TNF pathway to maintain liver homeostasis and may define a useful therapeutic target for liver diseases