33 research outputs found
Teaching introductory undergraduate physics using commercial video games
Commercial video games are increasingly using sophisticated physics simulations to create a more immersive experience for players. This also makes them a powerful tool for engaging students in learning physics. We provide some examples to show how commercial off-the-shelf games can be used to teach specific topics in introductory undergraduate physics. The examples are selected from a course taught predominantly through the medium of commercial video games
A Knowledge-Based Entrepreneurial Approach for Business Intelligence in Strategic Technologies: Bio-Mems
We propose a knowledge-based entrepreneurial (KBE) approach for business intelligence in strategic technologies at industrial sectors. The KBE approach is at the convergence of business intelligence and knowledge management and is used for advising users in business decisions and potential risks. Our approach comprises both a technology roadmap model as well as a knowledge-based entrepreneurial portal for various technologies. We use the Biological-Micro-Electrical-and- Mechanical-Systems industry (Bio-MEMS) to illustrate the approach. The technology roadmap model identifies the main actors, defines their roles and specifies the issues to be addressed. It handles information about main products, market trends, companies, research centers, application domains, products, standardization, and intellectual properties issues. The portal provides knowledge about the main actors through automation facilities based on digital libraries, searching and knowledge extraction from databases, data-ware houses and the Web. We explain how the KBE is helping Bio-MEMS users in business analysis
Repulsive photons in a quantum nonlinear medium
The ability to control strongly interacting light quanta (photons) is of
central importance in quantum science and engineering. Recently it was shown
that such strong interactions can be engineered in specially prepared quantum
optical systems. Here, we demonstrate a method for coherent control of strongly
interacting photons, extending quantum nonlinear optics into the domain of
repulsive photons. This is achieved by coherently coupling photons to several
atomic states, including strongly interacting Rydberg levels in a cold Rubidium
gas. Using this approach we demonstrate both repulsive and attractive
interactions between individual photons and characterize them by the measured
two- and three-photon correlation functions. For the repulsive case, we
demonstrate signatures of interference and self ordering from three-photon
measurements. These observations open a route to study strongly interacting
dissipative systems and quantum matter composed of light such as a crystal of
individual photons.Comment: 12 pages, 5 figure
Teaching introductory undergraduate Physics using commercial video games
Commercial video games are increasingly using sophisticated physics
simulations to create a more immersive experience for players. This also makes
them a powerful tool for engaging students in learning physics. We provide some
examples to show how commercial off-the-shelf games can be used to teach
specific topics in introductory undergraduate physics. The examples are
selected from a course taught predominantly through the medium of commercial
video games.Comment: Accepted to Physics Education, Fig1 does not render properly in this
versio
Navigation/Prop Software Suite
Navigation (Nav)/Prop software is used to support shuttle mission analysis, production, and some operations tasks. The Nav/Prop suite containing configuration items (CIs) resides on IPS/Linux workstations. It features lifecycle documents, and data files used for shuttle navigation and propellant analysis for all flight segments. This suite also includes trajectory server, archive server, and RAT software residing on MCC/Linux workstations. Navigation/Prop represents tool versions established during or after IPS Equipment Rehost-3 or after the MCC Rehost
Aquila: QuEra's 256-qubit neutral-atom quantum computer
The neutral-atom quantum computer "Aquila" is QuEra's latest device available
through the Braket cloud service on Amazon Web Services (AWS). Aquila is a
"field-programmable qubit array" (FPQA) operated as an analog Hamiltonian
simulator on a user-configurable architecture, executing programmable coherent
quantum dynamics on up to 256 neutral-atom qubits. This whitepaper serves as an
overview of Aquila and its capabilities: how it works under the hood, key
performance benchmarks, and examples that demonstrate some quintessential
applications. This includes an overview of neutral-atom quantum computing, as
well as five examples of increasing complexity from single-qubit dynamics to
combinatorial optimization, implemented on Aquila. This whitepaper is intended
for readers who are interested in learning more about neutral-atom quantum
computing, as a guide for those who are ready to start using Aquila, and as a
reference point for its performance as an analog quantum computer
A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells
The Sox6 transcription factor plays critical roles in various cell types, including erythroid cells. Sox6-deficient mice are anemic due to impaired red cell maturation and show inappropriate globin gene expression in definitive erythrocytes. To identify new Sox6 target genes in erythroid cells, we used the known repressive double Sox6 consensus within the Īµy-globin promoter to perform a bioinformatic genome-wide search for similar, evolutionarily conserved motifs located within genes whose expression changes during erythropoiesis. We found a highly conserved Sox6 consensus within the Sox6 human gene promoter itself. This sequence is bound by Sox6 in vitro and in vivo, and mediates transcriptional repression in transient transfections in human erythroleukemic K562 cells and in primary erythroblasts. The binding of a lentiviral transduced Sox6FLAG protein to the endogenous Sox6 promoter is accompanied, in erythroid cells, by strong downregulation of the endogenous Sox6 transcript and by decreased in vivo chromatin accessibility of this region to the PstI restriction enzyme. These observations suggest that the negative Sox6 autoregulation, mediated by the double Sox6 binding site within its own promoter, may be relevant to control the Sox6 transcriptional downregulation that we observe in human erythroid cultures and in mouse bone marrow cells in late erythroid maturation
Treatment Algorithm in Proliferative Diabetic Retinopathy - From Protocols to the Real World
Diabetes mellitus is a global epidemic that leads to multiple macrovascular and microvascular complications. The complex interrelated pathophysiological mechanisms triggered by hyperglycemia underlie the development of diabetic retinopathy (DR). Proliferative diabetic retinopathy (PDR) is a microvascular complication, considered the main cause of irreversible blindness in patients of productive age in the world. On the other hand, diabetic macular edema (DME) remains the clinical feature most closely associated with vision loss. In general, both manifestations are due to an increase in inflammatory factors, such as specific pro-inflammatory prostaglandins, interleukins and angiogenic substances including vascular endothelial growth factor (VEGF). Laser photocoagulation and VEGF inhibitors have been shown to be effective in the treatment of PDR and DME. Currently, randomized protocols suggest that VEGF inhibitors therapy could displace laser photocoagulation in the treatment of PDR with and without the presence of DME. The ongoing discussion still prevails about the different treatment modalities for both retinal manifestations in real-world settings