4,722 research outputs found
High power coupled CO2 waveguide laser array
A hollow-bore ridge waveguide technique for phase locking arrays of coupled CO2 rf excited waveguide lasers was demonstrated. Stable phase-locked operation of two- and three-channel arrays has been demonstrated at the 50 W output level. Preliminary experiments with a five-element array generated an output power of 95 W but phase-locked operation was not conclusively demonstrated
A new geometric invariant on initial data for Einstein equations
For a given asymptotically flat initial data set for Einstein equations a new
geometric invariant is constructed. This invariant measure the departure of the
data set from the stationary regime, it vanishes if and only if the data is
stationary. In vacuum, it can be interpreted as a measure of the total amount
of radiation contained in the data.Comment: 5 pages. Important corrections regarding the generalization to the
non-time symmetric cas
The Effects of Stacking on the Configurations and Elasticity of Single Stranded Nucleic Acids
Stacking interactions in single stranded nucleic acids give rise to
configurations of an annealed rod-coil multiblock copolymer. Theoretical
analysis identifies the resulting signatures for long homopolynucleotides: A
non monotonous dependence of size on temperature, corresponding effects on
cyclization and a plateau in the extension force law. Explicit numerical
results for poly(dA) and poly(rU) are presented.Comment: 4 pages and 2 figures. Accepted in Phys. Rev. E Rapid Com
On the existence of initial data containing isolated black holes
We present a general construction of initial data for Einstein's equations
containing an arbitrary number of black holes, each of which is instantaneously
in equilibrium. Each black hole is taken to be a marginally trapped surface and
plays the role of the inner boundary of the Cauchy surface. The black hole is
taken to be instantaneously isolated if its outgoing null rays are shear-free.
Starting from the choice of a conformal metric and the freely specifiable part
of the extrinsic curvature in the bulk, we give a prescription for choosing the
shape of the inner boundaries and the boundary conditions that must be imposed
there. We show rigorously that with these choices, the resulting non-linear
elliptic system always admits solutions.Comment: 11 pages, 2 figures, RevTeX
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Biosynthesis of the Cyclotide MCoTI-II using an Engineered Intein
Cyclotides are an emerging family of naturally occurring circular mini-proteins ({approx}30-40 amino acids) characterized by six conserved Cys residues (forming 3 disulfide bridges) that create a topologically unique structure designated as a cyclic cysteine knot (CCK). The cysteine knot motif, which is embedded within the macrocylic backbone, is described as two disulfide bridges that form a ring that is penetrated by the third disulfide bridge. The cyclic backbone and CCK motif together confer cyclotides with a remarkable stability and resistance to proteolytic, chemical, and thermal degradation. Further, cyclotides are functionally diverse and display a wide range of functions including uterotonic activity, trypsin inhibition, cytotoxicity, neurotensin binding, anti-HIV, antimicrobial, and insecticidal activity. Together, these characteristics make cyclotides attractive candidates for both drug design and agricultural applications, both in their native forms and as molecular scaffolds for the incorporation of novel bioactivities. [1] The ability to manipulate production of cyclotides within biological systems is critical for mutagenesis studies, production of grafted products, and the mass production of cyclotides with novel activities. My adviser's hope is to achieve this capability by employing recombinant DNA expression techniques to generate large combinatorial libraries of cyclotides. The advantage in creating a biosynthetic library (containing {approx}10{sup 6}-10{sup 10} members/library vs. chemically based libraries with typical values ranging from {approx}10{sup 3}-10{sup 5} members/library) is that it can be lead to the in vivo application of biological screening and selection methodologies based on a specific clone's ability to affect certain cellular processes
The Einstein constraints: uniqueness and non-uniqueness in the conformal thin sandwich approach
We study the appearance of multiple solutions to certain decompositions of
Einstein's constraint equations. Pfeiffer and York recently reported the
existence of two branches of solutions for identical background data in the
extended conformal thin-sandwich decomposition. We show that the Hamiltonian
constraint alone, when expressed in a certain way, admits two branches of
solutions with properties very similar to those found by Pfeiffer and York. We
construct these two branches analytically for a constant-density star in
spherical symmetry, but argue that this behavior is more general. In the case
of the Hamiltonian constraint this non-uniqueness is well known to be related
to the sign of one particular term, and we argue that the extended conformal
thin-sandwich equations contain a similar term that causes the breakdown of
uniqueness.Comment: 9 pages, 1 figur
Gating-by-tilt of mechanosensitive membrane channels
We propose an alternative mechanism for the gating of biological membrane
channels in response to membrane tension that involves a change in the slope of
the membrane near the channel. Under biological membrane tensions we show that
the energy difference between the closed (tilted) and open (untilted) states
can far exceed kBT and is comparable to what is available under simple
ilational gating. Recent experiments demonstrate that membrane leaflet
asymmetries (spontaneous curvature) can strong effect the gating of some
channels. Such a phenomenon would be more easy to explain under gating-by-tilt,
given its novel intrinsic sensitivity to such asymmetry.Comment: 10 pages, 2 figure
Stretching Semiflexible Polymer Chains: Evidence for the Importance of Excluded Volume Effects from Monte Carlo Simulation
Semiflexible macromolecules in dilute solution under very good solvent
conditions are modeled by self-avoiding walks on the simple cubic lattice
( dimensions) and square lattice ( dimensions), varying chain
stiffness by an energy penalty for chain bending. In the absence
of excluded volume interactions, the persistence length of the
polymers would then simply be with , the bond length being the lattice spacing,
and is the thermal energy. Using Monte Carlo simulations applying the
pruned-enriched Rosenbluth method (PERM), both and the chain length
are varied over a wide range ), and
also a stretching force is applied to one chain end (fixing the other end
at the origin). In the absence of this force, in a single crossover from
rod-like behavior (for contour lengths less than ) to swollen coils
occurs, invalidating the Kratky-Porod model, while in a double crossover
occurs, from rods to Gaussian coils (as implied by the Kratky-Porod model) and
then to coils that are swollen due to the excluded volume interaction. If the
stretching force is applied, excluded volume interactions matter for the force
versus extension relation irrespective of chain stiffness in , while
theories based on the Kratky-Porod model are found to work in for stiff
chains in an intermediate regime of chain extensions. While for in
this model a persistence length can be estimated from the initial decay of
bond-orientational correlations, it is argued that this is not possible for
more complex wormlike chains (e.g. bottle-brush polymers). Consequences for the
proper interpretation of experiments are briefly discussed.Comment: 23 pages, 17 figures, 2 tables, to be published in J. Chem. Phys.
(2011
Asymptotically Hyperbolic Non Constant Mean Curvature Solutions of the Einstein Constraint Equations
We describe how the iterative technique used by Isenberg and Moncrief to
verify the existence of large sets of non constant mean curvature solutions of
the Einstein constraints on closed manifolds can be adapted to verify the
existence of large sets of asymptotically hyperbolic non constant mean
curvature solutions of the Einstein constraints.Comment: 19 pages, TeX, no figure
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Anatomic brain asymmetry in vervet monkeys.
Asymmetry is a prominent feature of human brains with important functional consequences. Many asymmetric traits show population bias, but little is known about the genetic and environmental sources contributing to inter-individual variance. Anatomic asymmetry has been observed in Old World monkeys, but the evidence for the direction and extent of asymmetry is equivocal and only one study has estimated the genetic contributions to inter-individual variance. In this study we characterize a range of qualitative and quantitative asymmetry measures in structural brain MRIs acquired from an extended pedigree of Old World vervet monkeys (n = 357), and implement variance component methods to estimate the proportion of trait variance attributable to genetic and environmental sources. Four of six asymmetry measures show pedigree-level bias and one of the traits has a significant heritability estimate of about 30%. We also found that environmental variables more significantly influence the width of the right compared to the left prefrontal lobe
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