Optical production and detection of dark matter candidates

The PVLAS collaboration is at present running, at the Laboratori Nazionali di Legnaro of I.N.F.N., Padova, Italy, a very sensitive optical ellipsometer capable of measuring the small rotations or ellipticities which can be acquired by a linearly polarized laser beam propagating in vacuum through a transverse magnetic feld (vacuum magnetic birefringence). The apparatus will also be able to set new limits on mass and coupling constant of light scalar/pseudoscalar particles coupling to two photons by both producing and detecting the hypothetical particles. The axion, introduced to explain parity conservation in strong interactions, is an example of this class of particles, all of which are considered possible dark matter candidates. The PVLAS apparatus consists of a very high finesse (> 140000), 6.4 m long, Fabry-Perot cavity immersed in an intense dipolar magnetic field (~6.5 T). A linearly polarized laser beam is frequency locked to the cavity and analysed, using a heterodyne technique, for rotation and/or ellipticity acquired within the magnetic field.Comment: presented at "Frontier Detectors for Frontier Physics - 8th Pisa Meeting on Advanced Detectors - May 21-27, 2000" to appear in: Nucl.Instr. and Meth.

Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction

Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase and the maturation phase. Western blotting, laser confocal microscopy, Raman microscopy are valuable tools for studying the inflammatory response following myocardial infarction both humoral and cellular phase, allowing the identification and semiquantitative analysis of proteins produced during the inflammatory cascade activation and the topographical distribution and expression of proteins and cells involved in myocardial inflammation. Confocal laser scanning microscopy (CLSM) is a relatively new technique for microscopic imaging, that allows greater resolution, optical sectioning of the sample and three-dimensional reconstruction of the same sample. Western blotting used to detect the presence of a specific protein with antibody-antigen interaction in the midst of a complex protein mixture extracted from cells, produced semi-quantitative data quite easy to interpret. Confocal Raman microscopy combines the three-dimensional optical resolution of confocal microscopy and the sensitivity to molecular vibrations, which characterizes Raman spectroscopy. The combined use of western blotting and confocal microscope allows detecting the presence of proteins in the sample and trying to observe the exact location within the tissue, or the topographical distribution of the same. Once demonstrated the presence of proteins (cytokines, chemokines, etc.) is important to know the topographical distribution, obtaining in this way additional information regarding the extension of the inflammatory process in function of the time stayed from the time of myocardial infarction. These methods may be useful to study and define the expression of a wide range of inflammatory mediators at several different timepoints providing a more detailed analysis of the time course of the infarct

Detecting solar chameleons through radiation pressure

Light scalar fields can drive the accelerated expansion of the universe. Hence, they are obvious dark energy candidates. To make such models compatible with tests of General Relativity in the solar system and "fifth force" searches on Earth, one needs to screen them. One possibility is the so-called "chameleon" mechanism, which renders an effective mass depending on the local matter density. If chameleon particles exist, they can be produced in the sun and detected on Earth exploiting the equivalent of a radiation pressure. Since their effective mass scales with the local matter density, chameleons can be reflected by a dense medium if their effective mass becomes greater than their total energy. Thus, under appropriate conditions, a flux of solar chameleons may be sensed by detecting the total instantaneous momentum transferred to a suitable opto-mechanical force/pressure sensor. We calculate the solar chameleon spectrum and the reach in the chameleon parameter space of an experiment using the preliminary results from a force/pressure sensor, currently under development at INFN Trieste, to be mounted in the focal plane of one of the X-Ray telescopes of the CAST experiment at CERN. We show, that such an experiment signifies a pioneering effort probing uncharted chameleon parameter space.Comment: revised versio

Ellipsometry noise spectrum, suspension transfer function measurement and closed-loop control of the suspension system in the Q & A experiment

The Q & A experiment, aiming at the detection of vacuum birefringence predicted by quantum electrodynamics, consists mainly of a suspended 3.5 m Fabry-Perot cavity, a rotating permanent dipole magnet and an ellipsometer. The 2.3 T magnet can rotate up to 10 rev/s, introducing an ellipticity signal at twice the rotation frequency. The X-pendulum gives a good isolation ratio for seismic noise above its main resonant frequency 0.3 Hz. At present, the ellipsometry noise decreases with frequency, from 1*10^{-5} rad Hz^{-1/2} at 5 Hz, 2*10^{-6} rad Hz^{-1/2} at 20 Hz to 5*10^{-7} rad Hz^{-1/2} at 40 Hz. The shape of the noise spectrum indicates possible improvement can be made by further reducing the movement between the cavity mirrors. From the preliminary result of yaw motion alignment control, it can be seen that some peaks due to yaw motion of the cavity mirror was suppressed. In this paper, we first give a schematic view of the Q & A experiment, and then present the measurement of transfer function of the compound X-pendulum-double pendulum suspension. A closed-loop control was carried out to verify the validity of the measured transfer functions. The ellipsometry noise spectra with and without yaw alignment control and the newest improvement is presented.Comment: 7 pages, 5 figures, presented in 6th Edoardo Amaldi Conference on Gravitational Waves, June 2005, Okinawa Japan and submitted to Journal of Physics: Conference Series. Some modifications are made according to the referee's comments: mainly to explain the relation between the displacement of cavity mirror and the ellipticity noise spectru

Verification of a CT scanner using a miniature step gauge

The work deals with performance verification of a CT scanner using a 42mm miniature replica step gauge developed for optical scanner verification. Errors quantification and optimization of CT system set-up in terms of resolution and measurement accuracy are fundamental for use of CT scanning in dimensional metrology. Influence of workpiece orientation, magnification, source-object-detector distances and surface extraction method on metrological performances of a CT scanner was evaluated. Results show that the position of the workpiece in the CT cabinet is fundamental to get reliable measurements, while the highest magnification (best resolution) does not assure the best accuracy

Search for axions in streaming dark matter

A new search strategy for the detection of the elusive dark matter (DM) axion is proposed. The idea is based on streaming DM axions, whose flux might get temporally enormously enhanced due to gravitational lensing. This can happen if the Sun or some planet (including the Moon) is found along the direction of a DM stream propagating towards the Earth location. The experimental requirements to the axion haloscope are a wide-band performance combined with a fast axion rest mass scanning mode, which are feasible. Once both conditions have been implemented in a haloscope, the axion search can continue parasitically almost as before. Interestingly, some new DM axion detectors are operating wide-band by default. In order not to miss the actually unpredictable timing of a potential short duration signal, a network of co-ordinated axion antennae is required, preferentially distributed world-wide. The reasoning presented here for the axions applies to some degree also to any other DM candidates like the WIMPs.Comment: 5 page

Anti-cyclic-citrullinated-protein-antibodies in psoriatic arthritis patients: how autoimmune dysregulation could affect clinical characteristics, retention rate of methotrexate monotherapy and first line biotechnological drug survival. A single center retrospective study

Aim: Occasional findings of anti-cyclic-citrullinated-protein-antibodies (anti-CCP) were rarely observed in psoriatic arthritis (PsA). The aim of our study is to evaluate whether the presence of anti-CCP can determine different clinical subsets and influence methotrexate monotherapy survival, and biotechnological drug retention rate. Methods: We conducted a retrospective study on PsA patients. All patients were required to fulfill the CASPAR criteria for PsA, and to present juxta-articular osteo-proliferative signs at X-ray. The exclusion criteria were age less than 18 years old, satisfaction of rheumatoid arthritis classification criteria, and seropositivity for rheumatoid factor. Clinical characteristics, anti-CCP titer, drug survival and comorbidities information were recorded for each patient. Statistical significance was set at p ⩽ 0.05. Results: Of 407 patients with PsA screened 113 were recruited. Twelve patients were anti-CCP positive. Methotrexate monotherapy survival was shorter in patients with anti-CCP (150 ± 48.3 weeks versus 535.3 ± 65.3 weeks; p = 0.026) [discontinuation risk hazard ratio (HR) = 2.389, 95% confidence interval (CI) 1.043, 5.473; p = 0.039] than those without. Significant shorter survival of first-line biotechnological drugs (b-DMARDs) was observed in the anti-CCP positive group than in that without (102.05 ± 24.4 weeks versus 271.6 ± 41.7 weeks; p = 0.005) with higher discontinuation risk (HR = 3.230, 95% CI 1.299, 8.028; p = 0.012). A significant higher rate of multi-failure (more than second-line b-DMARDs) was found in anti-CCP positive patients than in those without (50% versus 14%, p = 0.035). Conclusion: Anti-CCP in PsA could be suggestive of more severe disease, with worse drug survival of both methotrexate monotherapy and first-line b-DMARDs, and higher chance to be b-DMARDs multi-failure. So, they can be considered for more intensive clinical management of these patients

Experimental observation of optical rotation generated in vacuum by a magnetic field

We report the experimental observation of a light polarization rotation in vacuum in the presence of a transverse magnetic field. Assuming that data distribution is Gaussian, the average measured rotation is (3.9+/-0.5)e-12 rad/pass, at 5 T with 44000 passes through a 1m long magnet, with lambda = 1064 nm. The relevance of this result in terms of the existence of a light, neutral, spin-zero particle is discussed.Comment: 11 pages, 4 figures, submitted to Physical Review Letters Comment to version 2: minor changes to abstract and final discussion. Added 2 references Comment to version 3: corrected minor typographical errors, eliminated the distinction between scalar and pseudoscalar in the particle interpretation of the resul