The Detection of Intergalactic Halpha Emission from the Slug Nebula at z~2.3

The Slug Nebula is one of the largest and most luminous Lyman-alpha (LyA) nebulae discovered to date, extending over 450 kiloparsecs (kpc) around the bright quasar UM287 at z=2.283. Characterized by high surface brightnesses over intergalactic scales, its LyA emission may either trace high-density ionized gas ("clumps") or large column densities of neutral material. To distinguish between these two possibilities, information from a non-resonant line such as Halpha is crucial. Therefore, we analyzed a deep MOSFIRE observation of one of the brightest LyA emitting regions in the Slug Nebula with the goal of detecting associated Halpha emission. We also obtained a deep, moderate resolution LyA spectrum of the nearby brightest region of the Slug. We detected an Halpha flux of F_(Halpha)= 2.62 +/- 0.47 x 10^-17 erg/cm^2/s (SB_(Halpha)=2.70 +/- 0.48 x 10^-18 erg/cm^2/s/sq") at the expected spatial and spectral location. Combining the Halpha detection with its corresponding LyA flux (determined from the narrow-band imaging) we calculate a flux ratio of F_(LyA_/F_(Halpha)= 5.5 +/- 1.1. The presence of a skyline at the location of the Halpha emission decreases the signal to noise ratio of the detection and our ability to put stringent constraints on the Halpha kinematics. Our measurements argue for the origin of the LyA emission being recombination radiation, suggesting the presence of high-density ionized gas. Finally, our high-resolution spectroscopic study of the LyA emission does not show evidence of a rotating disk pattern and suggest a more complex origin for at least some parts of the Slug Nebula.Comment: 17 pages, 9 figures, final version including referee's comments after acceptanc

Melanopsin retinal ganglion cell loss in Alzheimer's disease

Objective Melanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction. Methods We assessed retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (OCT) in 21 mild-moderate AD patients, and in a subgroup of 16 we evaluated rest-activity circadian rhythm by actigraphy. We studied postmortem mRGCs by immunohistochemistry in retinas, and axons in optic nerve cross-sections of 14 neuropathologically confirmed AD patients. We coimmunostained for retinal amyloid \u3b2 (A\u3b2) deposition and melanopsin to locate mRGCs. All AD cohorts were compared with age-matched controls. Results We demonstrated an age-related optic neuropathy in AD by OCT, with a significant reduction of RNFL thickness (p = 0.038), more evident in the superior quadrant (p = 0.006). Axonal loss was confirmed in postmortem AD optic nerves. Abnormal circadian function characterized only a subgroup of AD patients. Sleep efficiency was significantly reduced in AD patients (p = 0.001). We also found a significant loss of mRGCs in postmortem AD retinal specimens (p = 0.003) across all ages and abnormal mRGC dendritic morphology and size (p = 0.003). In flat-mounted AD retinas, A\u3b2 accumulation was remarkably evident inside and around mRGCs. Interpretation We show variable degrees of rest-activity circadian dysfunction in AD patients. We also demonstrate age-related loss of optic nerve axons and specifically mRGC loss and pathology in postmortem AD retinal specimens, associated with A\u3b2 deposition. These results all support the concept that mRGC degeneration is a contributor to circadian rhythm dysfunction in AD

TEXTAROSSA: Towards EXtreme scale Technologies and Accelerators for euROhpc hw/Sw Supercomputing Applications for exascale

International audienceTo achieve high performance and high energy efficiency on near-future exascale computing systems, three key technology gaps needs to be bridged. These gaps include: energy efficiency and thermal control; extreme computation efficiency via HW acceleration and new arithmetics; methods andtools for seamless integration of reconfigurable accelerators in heterogeneous HPC multi-node platforms. TEXTAROSSA aims at tackling this gap through a co-design approach to heterogeneous HPC solutions, supported by the integration and extension of HW and SW IPs, programming models and tools derived from European research

The detection of intergalactic H α emission from the Slug Nebula at z ∼ 2.3

The Slug Nebula is one of the largest and most luminous Lyman-alpha (LyA) nebulae discovered to date, extending over 450 kiloparsecs (kpc) around the bright quasar UM287 at z=2.283. Characterized by high surface brightnesses over intergalactic scales, its LyA emission may either trace high-density ionized gas ("clumps") or large column densities of neutral material. To distinguish between these two possibilities, information from a non-resonant line such as Halpha is crucial. Therefore, we analyzed a deep MOSFIRE observation of one of the brightest LyA emitting regions in the Slug Nebula with the goal of detecting associated Halpha emission. We also obtained a deep, moderate resolution LyA spectrum of the nearby brightest region of the Slug. We detected an Halpha flux of F_(Halpha)= 2.62 +/- 0.47 x 10^-17 erg/cm^2/s (SB_(Halpha)=2.70 +/- 0.48 x 10^-18 erg/cm^2/s/sq") at the expected spatial and spectral location. Combining the Halpha detection with its corresponding LyA flux (determined from the narrow-band imaging) we calculate a flux ratio of F_(LyA_/F_(Halpha)= 5.5 +/- 1.1. The presence of a skyline at the location of the Halpha emission decreases the signal to noise ratio of the detection and our ability to put stringent constraints on the Halpha kinematics. Our measurements argue for the origin of the LyA emission being recombination radiation, suggesting the presence of high-density ionized gas. Finally, our high-resolution spectroscopic study of the LyA emission does not show evidence of a rotating disk pattern and suggest a more complex origin for at least some parts of the Slug Nebula

Annali storici di Principato Citra, A. 2, n. 1.1 (2004)

A. 2, n. 1.1 (2004): G. Guardia, Editoriale per un amico, P. 2 ; F. Sofia, Piero Cantalupo : studioso e amico, P. 3 ; L. Rossi, Un ricordo e un grazie, P. 5 ; P. Cantalupo, Tradizioni mediche nei territori di Velia, Paestum e Salerno, P. 10 ; P. Cantalupo, Sulla cura dei vinaccioli: il cinquecentesco opuscolo di Donato Antonio Altomare medico di Valle Cilento, P. 66 ; P. Cantalupo, Dati sulla storia e lo sviluppo urbanistico dei siti antropizzati del Comune di Stella Cilento in provincia di Salerno, P. 131 ; F. La Greca, Ricordo di Piero Cantalupo, P. 163

Bollettino storico di Salerno e Principato Citra. A.5, n.1 (1987)

A.5, n.1 (1987): V. Cimmelli, I Capitoli dell’Università di Postiglione, P. 5 ; P. Cantalupo, Per un contributo alla storia della Diocesi di Capaccio-Scalo: Aspetti del culto delle reliquie nel Settecento, P. 11 ; G.A. Colangelo, Il Monte dei Maritaggi della Santissima Annunziata dello Stato di Montecorvino, P. 29 ; B. Olivieri, Un conservatorio di Principato Citra: S. Sofia in Montecorvino Rovella, P. 39 ; A. Infante, Torchiara e il suo palazzo baronale, P. 51 ; G. D’Ajello, Il manoscritto del Prignano e le fonti nello studio della Famiglia D’Ajello, P. 63

Bollettino storico di Salerno e Principato Citra. A.4, n.2 (1986)

A.4, n.2 (1986): V. Cimmelli, L'imposizione della decima ed il partito del grano ad Angri sai finire del secolo XVI, P. 5 ; G. Guardia, Salerno: l’immagine scritta tra '600 e '700, P. 19 ; P. Cantalupo, Due ignorate testimonianze archeologiche: i frammenti di sarcofago a Vatolla ed i ruderi sull'isoletta di Licosa, P. 27 ; S. Borsi, Alle origini del Grand Tour: le antichità campane e i maestri rinascimentali, P. 35 ; D. Sinigalliesi, Un pittore napoletano del Cinquecento: Severo Ierace, P. 47 ; D. Galasso, Considerazioni su Francesco Guarino da Solofra, P. 55 ; G. Trassari, Appunti sui problemi d'indagine relativi ai processi di deterioramento ed alle morfologie dei degradi delle matrici in rame incise. In margine al « restauro » della pianta di Napoli del duca di Noja, P. 65 ; G. Guardia, « Andrea da Salerno nel Rinascimento meridionale ». Note in margine alla mostra, P. 73