Magnetic field and prominences of the young, solar-like, ultra-rapid rotator V530 Persei

This work benefited from the support of Programme National de Physique Stellaire (PNPS). T.C. would like to acknowledge financial support from the China Scholarship Council (CSC). J.F.D. and A.A.V. acknowledges funding from from the European Research Council (ERC) under the H2020 research & innovation programme (grant agreement # 740651 NewWorlds and # 817540 ASTROFLOW).Context. Young solar analogs reaching the main sequence experience very strong magnetic activity, generating angular momentum losses through wind and mass ejections. Aims. We investigate signatures of magnetic fields and activity at the surface and in the prominence system of the ultra-rapid rotator V530 Per, a G-type solar-like member of the young open cluster α Persei. This object has a rotation period that is shorter than all stars with available magnetic maps. Methods. With a time-series of spectropolarimetric observations gathered with ESPaDOnS over two nights on the Canada-France-Hawaii Telescope, we reconstructed the surface brightness and large-scale magnetic field of V530 Per using the Zeeman-Doppler imaging method, assuming an oblate stellar surface. We also estimated the short term evolution of the brightness distribution through latitudinal differential rotation. Using the same data set, we finally mapped the spatial distribution of prominences through tomography of the Hα emission.  Results. The brightness map is dominated by a large, dark spot near the pole, accompanied by a complex distribution of bright and dark features at lower latitudes. Taking the brightness map into account, the magnetic field map is reconstructed as well. Most of the large-scale magnetic field energy is stored in the toroidal field component. The main radial field structure is a positive region of about 500 G, at the location of the dark polar spot. The brightness map of V530 Per is sheared by solar-like differential rotation, with roughly a solar value for the difference in rotation rate between the pole and equator. It is important to note that Hα is observed in emission and it is mostly modulated by the stellar rotation period over one night. The prominence system is organized in a ring at the approximate location of the corotation radius, and displays significant evolution between the two observing nights.  Conclusions. V530 Per is the first example of a solar-type star to have its surface magnetic field and prominences mapped together, which will bring important observational constraints to better understand the role of slingshot prominences in the angular momentum evolution of the most active stars.Publisher PDFPeer reviewe

Angular Momentum Mixing in Crystalline Color Superconductivity

In crystalline color superconductivity, quark pairs form at non-zero total momentum. This crystalline order potentially enlarges the domain of color superconductivity in cold dense quark matter. We present a perturbative calculation of the parameters governing the crystalline phase and show that this is indeed the case. Nevertheless, the enhancement is modest, and to lowest order is independent of the strength of the color interaction.Comment: 9 pages, 2 figures, Revte

Precise determination of stellar parameters of the ZZ Ceti and DAZ white dwarf GD 133 through asteroseismology

An increasing number of white dwarf stars show atmospheric chemical composition polluted by heavy elements accreted from debris disk material. The existence of such debris disks strongly suggests the presence of one or more planet(s) whose gravitational interaction with rocky planetesimals is responsible for their disruption by tidal effect. The ZZ Ceti pulsator and polluted DAZ white dwarf GD 133 is a good candidate for searching for such a potential planet. We started in 2011 a photometric follow-up of its pulsations. As a result of this work in progress, we used the data gathered from 2011 to 2015 to make an asteroseismological analysis of GD 133, providing the star parameters from a best fit model with $M$/$M_{\odot}$ = 0.630 $\pm$ 0.002, $T_{\rm eff}$ = 12400 K $\pm$ 70 K, log($M_{\rm He}/M$) = -2.00 $\pm$ 0.02, log($M_{\rm H}/M$) = -4.50 $\pm$ 0.02 and determining a rotation period of $\approx$ 7 days.Comment: 10 pages, 13 figures, accepted by MNRA

The SPIRou Legacy Survey Rotation period of quiet M dwarfs from circular polarization in near-infrared spectral lines: I. The SPIRou APERO analysis

Context. The rotation period of stars is an important parameter along with mass, radius, effective temperature. It is an essential parameter for any radial velocity monitoring, as stellar activity can mimic the presence of a planet at the stellar rotation period. Several methods exist to measure it, including long sequences of photometric measurements or temporal series of stellar activity indicators. Aims. Here, we use the circular polarization in near-infrared spectral lines for a sample of 43 quiet M dwarfs and compare the measured rotation periods to those obtained with other methods. Methods. From Stokes V spectropolarimetric sequences observed with SPIRou at CFHT and the data processed with the APERO pipeline, we compute the least squares deconvolution profiles using different masks of atomic stellar lines with known Land\'e factor appropriate to the effective temperature of the star. We derive the longitudinal magnetic field to examine its possible variation along the 50 to 200 observations of each star. For determining the stellar rotation period, we apply a Gaussian process regression enabling us to determine the rotation period of stars with evolving longitudinal field. Results. Among the 43 stars of our sample, we were able to measure a rotation period for 27 stars. For 8 stars, the rotation period was previously unknown. We find a good agreement of our rotation periods with periods found in the literature based on photometry and activity indicators and confirm that near-infrared spectropolarimetry is an important tool to measure rotation periods, even for magnetically quiet stars. Furthermore, we compute ages for 20 stars of our sample using gyrochronology

Neural circuits controlling behavior and autonomic functions in medicinal leeches

In the study of the neural circuits underlying behavior and autonomic functions, the stereotyped and accessible nervous system of medicinal leeches, Hirudo sp., has been particularly informative. These leeches express well-defined behaviors and autonomic movements which are amenable to investigation at the circuit and neuronal levels. In this review, we discuss some of the best understood of these movements and the circuits which underlie them, focusing on swimming, crawling and heartbeat. We also discuss the rudiments of decision-making: the selection between generally mutually exclusive behaviors at the neuronal level

Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience

Rituximab is a human/murine, chimeric anti-CD20 monoclonal antibody with established efficacy, and a favorable and well-defined safety profile in patients with various CD20-expressing lymphoid malignancies, including indolent and aggressive forms of B-cell non-Hodgkin lymphoma. Since its first approval 20 years ago, intravenously administered rituximab has revolutionized the treatment of B-cell malignancies and has become a standard component of care for follicular lymphoma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia, and mantle cell lymphoma. For all of these diseases, clinical trials have demonstrated that rituximab not only prolongs the time to disease progression but also extends overall survival. Efficacy benefits have also been shown in patients with marginal zone lymphoma and in more aggressive diseases such as Burkitt lymphoma. Although the proven clinical efficacy and success of rituximab has led to the development of other anti-CD20 monoclonal antibodies in recent years (e.g., obinutuzumab, ofatumumab, veltuzumab, and ocrelizumab), rituximab is likely to maintain a position within the therapeutic armamentarium because it is well established with a long history of successful clinical use. Furthermore, a subcutaneous formulation of the drug has been approved both in the EU and in the USA for the treatment of B-cell malignancies. Using the wealth of data published on rituximab during the last two decades, we review the preclinical development of rituximab and the clinical experience gained in the treatment of hematologic B-cell malignancies, with a focus on the well-established intravenous route of administration. This article is a companion paper to A. Davies, et al., which is also published in this issue

Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi

BACKGROUND: Smoking is known to cause chronic inflammatory changes in the bronchi and to contribute to airway hyper-reactivity, such as in bronchial asthma. To study the effect of smoking on the endothelin system in rat airways, bronchial segments were exposed to DMSO-soluble smoking particles (DSP) from cigarette smoke, to nicotine and to DMSO, respectively. METHODS: Isolated rat bronchial segments were cultured for 24 hours in the presence or absence of DSP, nicotine or DMSO alone. Contractile responses to sarafotoxin 6c (a selective agonist for ET(B )receptors) and endothelin-1 (an ET(A )and ET(B )receptor agonist) were studied by use of a sensitive myograph. Before ET-1 was introduced, the ET(B )receptors were desensitized by use of S6c. The remaining contractility observed was considered to be the result of selective activation of the ET(A )receptors. ET(A )and ET(B )receptor mRNA expression was analyzed using real-time quantitative PCR. The location and concentration of ET(A )and ET(B )receptors were studied by means of immunohistochemistry together with confocal microscopy after overnight incubation with selective antibodies. RESULTS: After being cultured together with DSP for 24 hours the bronchial segments showed an increased contractility mediated by ET(A )and ET(B )receptors, whereas culturing them together with nicotine did not affect their contractility. The up-regulation of their contractility was blunted by cycloheximide treatment, a translational inhibitor. No significant change in the expression of ET(A )and ET(B )receptor mRNA through exposure to DMSO or to nicotine exposure alone occurred, although immunohistochemistry revealed a clear increase in ET(A )and ET(B )receptors in the smooth muscle after incubation in the presence of DSP. Taken as a whole, this is seen as the presence of a translation mechanism. CONCLUSION: The increased contractility of rat bronchi when exposed to DSP appears to be due to a translation mechanism

Computer-Based Screening of Functional Conformers of Proteins

A long-standing goal in biology is to establish the link between function, structure, and dynamics of proteins. Considering that protein function at the molecular level is understood by the ability of proteins to bind to other molecules, the limited structural data of proteins in association with other bio-molecules represents a major hurdle to understanding protein function at the structural level. Recent reports show that protein function can be linked to protein structure and dynamics through network centrality analysis, suggesting that the structures of proteins bound to natural ligands may be inferred computationally. In the present work, a new method is described to discriminate protein conformations relevant to the specific recognition of a ligand. The method relies on a scoring system that matches critical residues with central residues in different structures of a given protein. Central residues are the most traversed residues with the same frequency in networks derived from protein structures. We tested our method in a set of 24 different proteins and more than 260,000 structures of these in the absence of a ligand or bound to it. To illustrate the usefulness of our method in the study of the structure/dynamics/function relationship of proteins, we analyzed mutants of the yeast TATA-binding protein with impaired DNA binding. Our results indicate that critical residues for an interaction are preferentially found as central residues of protein structures in complex with a ligand. Thus, our scoring system effectively distinguishes protein conformations relevant to the function of interest