Intracavity intensity noise suppression in the inverse Compton scattering source BriXSinO exploiting carrier-envelope offset manipulation

We report on a technique that exploits the control of the carrier -envelope offset to suppress the frequency-to-intensity noise conversion in the locking of a mode-locking laser against a high-finesse optical enhancement resonator. A proper combination of the laser carrier-envelope offset and the resonator finesse allows the improvement of the signal-to-noise ratio of the optical intensity trapped into the optical resonator. In this paper, we show the application of this technique in the laser system of the inverse Compton scattering source BriXSinO, currently under development in Milan, Italy, demonstrating the possibility of achieving an intracavity intensity noise reduction of a factor of 20

Carrier-envelope offset frequency measurement by means of an external optical resonator

A general-purpose method based on the implementation of the asymmetric Pound-Drever-Hall (PDH) technique is proposed to measure the carrier-envelope offset (CEO) frequency of a mode-locked laser using an external optical cavity. By analyzing the synchronously demodulated signal of the spectrally filtered cavity reflection when the optical resonator is locked to the mode-locked laser, a discriminating signal depending on the relative frequency offset between the mode-locked and optical cavity comb-like spectra is obtained. For a given geometry and group delay dispersion (GDD) of the cavity parameters (i.e., a known cavity mode offset), this signal can be used to retrieve the laser CEO. This approach turns out to be advantageous in terms of setup complexity with respect to other well-known techniques that rely on non-linear frequency generation, such as f-2f interferometers. In addition, this method can be used to precisely determine the laser-cavity spectral coupling, which is an important topic in cavity-enhanced spectroscopy and non-linear optics applications. After the theoretical description of the generalized asymmetric PDH signal, an experimental validation of the proposed method is reported using an Er-doped fiber frequency comb source centered at 1,550 nm, with a repetition rate of 250 MHz, locked to a linear optical cavity with a 1 GHz free spectral range. The theoretical effect of the GDD is confirmed experimentally using different cavity configurations. Moreover, the comparison with the CEO frequency values measured using an f-2f interferometer demonstrates the feasibility of the proposed method

Estudio ecocardiográfico y de la concentración de NT-proBNP en pacientes diabéticos tipo 2 con y sin cardiopatía isquémica

The aim of this study was to determine whether there are differences in echocardiographic findings or in the level of a biochemical marker (i.e. N-terminal probrain natriuretic peptide [NT-proBNP]) between controls and type-2 diabetic patients with or without ischemic heart disease. Echocardiography was used to assess left ventricular function and morphology. In addition, the plasma NT-proBNP concentration was measured. The prevalence of diastolic dysfunction was greater in diabetics without ischemic heart disease than in controls (88% vs. 74%, respectively; P< .001) and the NT-proBNP concentration was higher (350.6+/-197.8 vs. 281.7+/-190.4 fmol/mL; P< .001). Diabetics with ischemic heart disease had a higher NT-proBNP concentration than those without (720.4+/-278.1 vs. 350.6+/-197.8 fmol/mL, respectively; P< .001). An NT-proBNP concentration >490 fmol/mL had a sensitivity of 84% and a specificity of 75% for detecting ischemic heart disease in diabetics

Design and Optimization of a Pneumatic Clamping System for Direct-Driven Rotary Tables

Modern direct-driven and high-speed rotary tables with torque motor are optimally suited for all handling and assembly applications that require the shortest indexing times and flexible positioning. The following paper is devoted to the study, the design, and the optimization of an innovative table clamping system (brake for accurate positioning) actuated by pneumatic energy, working at a maximum clamping pressure of 6 bar. The challenge for the aforementioned application is related to developing a solution able to provide a maximum tangential torque (with clamping actuated) in the range of thousands of Nm without leveraging the use of high-pressure hydraulic energy. The optimization of the proposed solution is based on the precise calculation of the stresses in order to perform a fatigue assessment and on the elastic deformation of the clamps in order to set the correct tolerances between the mating parts. Eventually, an experimental campaign is carried out in order to tune the numerical model, which is then used to validate the proposed design solution

Insuficiencia cardíaca. Tratamiento farmacológico actual

Treatment of heart failure (HF) has changed in recent years, despite the paucity of new approved drugs. Current treatment is directed not only towards improving symptoms, but also to preventing the development from asymptomatic systolic dysfunction to symptomatic heart failure, to preventing cardiac remodelling, renal dysfunction and to reducing mortality. The main families of drugs currently used are: cardiac glycosides, diuretics, angiotensin-converting enzyme inhibitors (ACEI), beta-blocking drugs (BB), angiotensin-II receptor blockers (ARB) and aldosterone receptor antagonists. The combination isosorbide dinitrate + hydralazine is hardly used due to its side effects and none of the new positive inotropic drugs has been approved in chronic HF, because all of them increase mortality. Levosimendan is a new positive inotropic agent approved for acute HF by an intravenous route, with a favourable effect on prognosis vs placebo and vs dobutamine (which worsens the prognosis). The approved oral drugs can be given at the same time if the patient tolerates them, because their beneficial effect is additive. Mortality in two years in mild to moderate HF is 34% with glycosides + diuretics. It falls to 22% when an ACEI is added, to 14% when a BB is added and to 10% when an aldosterone antagonist is added. ARB can be given instead of an ACEI or be added to the other drugs

Patient-reported experiences of cancer care related to the COVID-19 pandemic in Switzerland.

This study aims to describe the experience of Swiss oncological patients during the COVID-19 pandemic. A national multi-center study including five hospitals covering the three main language regions of Switzerland was conducted between March and July 2021. Patients with melanoma, breast, lung, or colon cancer receiving active systemic anti-cancer treatment at the time of the COVID-19 pandemic were included. We conducted semi-structured telephone or onsite interviews alongside the administration of distress and resilience-validated questionnaires. Thematic analysis was performed for the qualitative data and descriptive statistics for the quantitative data. Sixty-two cancer patients with a mean age of 61 (SD=14) (58% female) were interviewed. Based on the interviews, we identified that the experience of having cancer during the COVID-19 pandemic was related to five dimensions: psychological, social, support, healthcare, and vaccination. Three themes transverse the five dimensions: (a) needs, (b) positive changes, and (c) phases of the pandemic. In general, patients did not experience delays or disruptions in their cancer treatment nor felt additionally burdened by the pandemic. Lockdown and isolation were reported as mixed experiences (positive and negative), and access to vaccination reassured patients against the risk of infection and instilled hope to return to normalcy. Additionally, we found low distress levels (M=2.9; SD=2.5) and high resilience scores (M=7; SD=1.3) in these patients. Swiss patients with cancer did not express major needs or disruptions in their care during this period of the COVID-19 pandemic. Results identify the mixed experiences of patients and highlight the high resilience levels

Medicine expenses and obesity in Brazil: an analysis based on the household budget survey

Abstract\ud \ud Background\ud Obesity can be considered a global public health problem that affects virtually all countries worldwide and results in greater use of healthcare services and higher healthcare costs. We aimed to describe average monthly household medicine expenses according to source of funding, public or private, and to estimate the influence of the presence of obese residents in households on total medicine expenses.\ud \ud \ud Methods\ud This study was based on data from the 2008–2009 Brazilian Household Budget Survey, with a representative population sample of 55,970 households as study units. Information on nutritional status and medicines acquired and their cost in the past 30 days were analyzed. A two-part model was employed to assess the influence of obesity on medicine expenses, with monthly household medicine expenses per capita as outcome, presence of obese in the household as explanatory variable, and adjustment for confounding variables.\ud \ud \ud Results\ud Out-of-pocket expenses on medicines were always higher than the cost of medicines obtained through the public sector, and 32 % of households had at least one obese as resident. Monthly household expenses on medicines per capita in households with obese was US$ 20.40, 16 % higher than in households with no obese. An adjusted model confirmed that the presence of obese in the households increased medicine expenses.\ud \ud \ud Conclusion\ud Obesity is associated with additional medicine expenses, increasing the negative impact on household budgets and public expenditure.We are grateful to the the Fundação de Amparo à Pesquisa do Estado de\ud São Paulo (FAPESP) for the research grant (process number 2012/17977-4)\ud and to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior\ud (CAPES) for the doctoral scholarship to DSC

Superconducting RFQs

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Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women

Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling and in-vivo chemogenetic manipulations in mice, we first show that a time-series metric estimated from fMRI BOLD signal, the Hurst exponent (H), can be an index for underlying change in the synaptic E:I ratio. In autism we find that H is reduced, indicating increased excitation, in the medial prefrontal cortex (MPFC) of autistic males but not females. Increasingly intact MPFC H is also associated with heightened ability to behaviorally camouflage social-communicative difficulties, but only in autistic females. This work suggests that H in BOLD can index synaptic E:I ratio and that E:I imbalance affects autistic males and females differently