Estatuto de protección al menor de edad en el Código del Trabajo de 1931

This article analyzes the characteristics of legal regulation of child labor, since the Labor Code of 1931 to the specific regulation of Decree Law No. 2200, known as "Labor Plan". Previously, it analyzes the political, economic and legal conditions that made possible and necessary a special regulation for child labor, since the Industrial Revolution, which created the conditions for the widespread use of such labor, to the phenomenon of decoding, which led to the enactment of special laws in detriment of a Civil Code, which increasingly lost more regulatory power.El presente artículo analiza las características de la regulación legal del trabajo de menores, desde el Código del Trabajo de 1931 hasta la específica regulación del Decreto Ley N° 2.200, conocido como “Plan Laboral”. Previo a ello, analiza las condiciones políticas, económicas y jurídicas que posibilitaron e hicieron necesaria una regulación especial para el trabajo de menores, desde la revolución industrial, que generó las condiciones para la utilización masiva de mano de obra infantil, hasta el fenómeno de la descodificación, que dio paso a la dictación de leyes especiales en detrimento de un Código Civil, que perdía cada vez más fuerza regulatoria

Optical properties of microstructured fibre tuned by filling with magnetic liquids

Alternative for adjust optical fiber light-guiding properties by bulk glass doping is provided by microstructured optical fibers, which allows access directly to the light guiding core via their microstructure. Following paper will report utilizing of suspended-core, so-called high-delta, microstructured optical fiber as an optimal medium for tuning and developing optical devices. Means of filling such fiber with variety of liquids will be presented and guided light affection in bare silica glass fiber will be demonstrated

Neural networks for classification of strokes in electrical impedance tomography on a 3D head model

We consider the problem of the detection of brain hemorrhages from three dimensional (3D) electrical impedance tomography (EIT) measurements. This is a condition requiring urgent treatment for which EIT might provide a portable and quick diagnosis. We employ two neural network architectures -- a fully connected and a convolutional one -- for the classification of hemorrhagic and ischemic strokes. The networks are trained on a dataset with $40\,000$ samples of synthetic electrode measurements generated with the complete electrode model on realistic heads with a 3-layer structure. We consider changes in head anatomy and layers, electrode position, measurement noise and conductivity values. We then test the networks on several datasets of unseen EIT data, with more complex stroke modeling (different shapes and volumes), higher levels of noise and different amounts of electrode misplacement. On most test datasets we achieve $\geq 90\%$ average accuracy with fully connected neural networks, while the convolutional ones display an average accuracy $\geq 80\%$. Despite the use of simple neural network architectures, the results obtained are very promising and motivate the applications of EIT-based classification methods on real phantoms and ultimately on human patients.Comment: 17 pages, 11 figure

Computational framework for applying electrical impedance tomography to head imaging

This work introduces a computational framework for applying absolute electrical impedance tomography to head imaging without accurate information on the head shape or the electrode positions. A library of fifty heads is employed to build a principal component model for the typical variations in the shape of the human head, which leads to a relatively accurate parametrization for head shapes with only a few free parameters. The estimation of these shape parameters and the electrode positions is incorporated in a regularized Newton-type output least squares reconstruction algorithm. The presented numerical experiments demonstrate that strong enough variations in the internal conductivity of a human head can be detected by absolute electrical impedance tomography even if the geometric information on the measurement configuration is incomplete to an extent that is to be expected in practice.Comment: 25 pages, 12 figure

Role of the European Food Safety Authority (EFSA) in providing scientific advice on the welfare of food producing animals

The survey describes the work of the Animal Health and Welfare (AHAW) Panel of the European Food Safety Authority (EFSA) in the provision of scientific advice on the welfare of food producing animals including animal health and food safety aspects, where relevant, and on the impact of these scientific assessments on the EU regulatory framework. EFSA was created in 2002 with the mission to provide advice and scientific and technical support for the Community legislation and policies in all fields which have a direct or indirect impact on food and feed safety, plant health, environment and animal health and animal welfare. When providing objective and independent science-based advice, the risk assessment approach should be followed, whenever possible. The AHAW Panel of EFSA provides specific advices on risk factors related to animal diseases and welfare, mainly of food producing animals, including fish. According to EFSA's remit, ethical, socio-economic, cultural and religious aspects are outside the scope of the EFSA's assessments. Since 2004, the Animal Health and Welfare Panel of EFSA adopted a total of 21 scientific opinions on animal welfare. Animal diseases and food safety aspects have also been taken into account, where relevant. Animal welfare aspects have been considered in some scientific opinions on animal diseases (e.g. AI, FMD). The AHAW Panel is currently working on five scientific opinions on the welfare of dairy cows and on the welfare aspects of the stunning and killing of farmed fish for eight fish species (salmon, trout, carp, eel, tuna, sea bass, sea bream and turbot). The possible interactions and implications for food safety and animal disease have been considered, when relevant, in most of the AW scientific opinions, involving other areas of expertise in EFSA, like Biohazards, Contaminants and Plant Health. The final aim of EFSA's scientific assessments on animal welfare is to support animal welfare EU legislation on the basis of the available scientific evidence. Many examples illustrate how EFSA's scientific opinions are taken into consideration when legislative measures are proposed by the European Commission. In order to evaluate the overall impact of animal welfare, factors with possible incidence on animal diseases and food safety should also be considered. The evaluation of the interactions between animal welfare, animal disease and food safety could help the development of control and monitoring plans at farm level

Toward Risk Assessment for Amniotic Fluid Embolisms

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A hybrid time-frequency parametric modelling of medical ultrasound signal transmission

Medical ultrasound imaging is the most widespread real-time non-invasive imaging system and its formulation comprises signal transmission, signal reception, and image formation. Ultrasound signal transmission modelling has been formalized over the years through different approaches by exploiting the physics of the associated wave problem. This work proposes a novel computational framework for modelling the ultrasound signal transmission step in the time-frequency domain for a linear-array probe. More specifically, from the impulse response theory defined in the time domain, we derived a parametric model in the corresponding frequency domain, with appropriate approximations for the narrowband case. To validate the model, we implemented a numerical simulator and tested it with synthetic data. Numerical experiments demonstrate that the proposed model is computationally feasible, efficient, and compatible with realistic measurements and existing state-of-the-art simulators. The formulated model can be employed for analyzing how the involved parameters affect the generated beam pattern, and ultimately for optimizing measurement settings in an automatic and systematic way

Size matters for in vitro gene delivery: investigating the relationships among complexation protocol, transfection medium, size and sedimentation

Although branched and linear polyethylenimines (bPEIs and lPEIs) are gold standard transfectants, a systematic analysis of the effects of the preparation protocol of polyplexes and the composition of the transfection medium on their physicochemical behaviour and effectiveness in vitro have been much neglected, undermining in some way the identification of precise structure-function relationships. This work aimed to address these issues. bPEI/DNA and lPEI/DNA, prepared using two different modes of addition of reagents, gave rise to polyplexes with exactly the same chemical composition but differing in dimensions. Upon dilution in serum-free medium, the size of any kind of polyplex promptly rose over time while remained invariably stable in complete DMEM. Of note, the bigger the dimension of polyplexes (in the nano- to micrometer range), the greater their efficiency in vitro. Besides, centrifugal sedimentation of polyplexes displaying different dimensions to speed up and enhance their settling onto cells boosted transfection efficiencies. Conversely, transgene expression was significantly blunted in cells held upside-down and transfected, definitively pointing out the impact of gravitational sedimentation of polyplexes on their transfection efficiency. Overall, much more attention must be paid to the actual polyplex size that relies on the complexation conditions and the transfection medium

Microfluidic Platform for Adherent Single Cell High-Throughput Screening

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.Traditionally, in vitro investigations on biology and physiology of cells rely on averaging the responses eliciting from heterogeneous cell populations, thus being unsuitable for assessing individual cell behaviors in response to external stimulations. In the last years, great interest has thus been focused on single cell analysis and screening, which represents a promising tool aiming at pursuing the direct and deterministic control over cause-effect relationships guiding cell behavior. In this regard, a high-throughput microfluidic platform for trapping and culturing adherent single cells was presented. A single cell trapping mechanism was implemented based on dynamic variation of fluidic resistances. A round-shaped culture chamber (Φ=250μm, h=25μm) was conceived presenting two connections with a main fluidic path: (i) an upper wide opening, and (ii) a bottom trapping junction which modulates the hydraulic resistance. Several layouts of the chamber were designed and computationally validated for the optimization of the single cell trapping efficacy. The optimized chamber layouts were integrated in a polydimethylsiloxane (PDMS) microfluidic platform presenting two main functionalities: (i) 288 chambers for trapping single cells, and (ii) a chaoticmixer based serial dilution generator for delivering both soluble factors and non-diffusive molecules under spatio-temporally controlled chemical patterns. The devices were experimentally validated and allowed for trapping individual U87-MG (human glioblastoma-astrocytoma epithelial-like) cells and culturing them up to 3 days