Deaths due to oral cancer in Chile in the period 2002-2012

Indexación: Scopus; Scielo.Background: Oral cancer is the 15th most common cause of cancer death in the world. In Chile, 1% of all cancer deaths are related to oral and pharyngeal cancer. Aim: To determine mortality rates for oral cancer in Chile and its regions between 2002-2012. Material and Methods: Deaths and their causes between the years 2002-2012 were obtained from the Chilean National Statistics Institute. Crude and adjusted rates by age and sex were calculated for the country and its regions. The denominator was Chilean population on June 30, 2012 and the WHO standard population. Results: In the period studied, 1,611 individuals with a mean age of 67.6 years (63% men) died because of oral cancer. The most common location of the tumor was the tongue in 27% of cases and the parotid gland in 16%. The adjusted mortality rate in Chile was 0.85/100,000 inhabitants (1.13 and 0.58 in men and women, respectively). The regions with the highest rates were Antofagasta (1.51), Aysén (1.22) and Magallanes (1.17). Deaths among men occurred at younger ages than women. Conclusions: Mortality rates due to oral cancer in Chile are lower than abroad. The highest rates observed in some regions may be influenced by environmental factors such as arsenic contamination in Antofagasta and the lack of specialists and specialized care centers in Aysén and Magallanes. © 2018, Sociedad Medica de Santiago. All rights reserved.https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000400487&lng=en&nrm=iso&tlng=e

Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential

Marine alkaloids belonging to the lamellarins family, which incorporate a 5,6-dihydro-1-phenylpyrrolo[2,1-a]isoquinoline (DHPPIQ) moiety, possess various biological activities, spanning from antiviral and antibiotic activities to cytotoxicity against tumor cells and the reversal of multidrug resistance. Expanding a series of previously reported imino adducts of DHPPIQ 2-carbaldehyde, novel aliphatic and aromatic Schiff bases were synthesized and evaluated herein for their cytotoxicity in five diverse tumor cell lines. Most of the newly synthesized compounds were found noncytotoxic in the low micromolar range (<30 μM). Based on a Multi-fingerprint Similarity Search aLgorithm (MuSSeL), mainly conceived for making protein drug target prediction, some DHPPIQ derivatives, especially bis-DHPPIQ Schiff bases linked by a phenylene bridge, were prioritized as potential hits addressing Alzheimer's disease-related target proteins, such as cholinesterases (ChEs) and monoamine oxidases (MAOs). In agreement with MuSSeL predictions, homobivalent para-phenylene DHPPIQ Schiff base 14 exhibited a noncompetitive/mixed inhibition of human acetylcholinesterase (AChE) with Ki in the low micromolar range (4.69 μM). Interestingly, besides a certain inhibition of MAO A (50% inhibition of the cell population growth (IC50) = 12 μM), the bis-DHPPIQ 14 showed a good inhibitory activity on self-induced β-amyloid (Aβ)1-40 aggregation (IC50 = 13 μM), which resulted 3.5-fold stronger than the respective mono-DHPPIQ Schiff base 9

Cosmic ray spectrum and anisotropies from the knee to the second knee

We consider the scenario in which the knee in the cosmic ray spectrum is due to a change in the escape mechanism of cosmic rays from the Galaxy from one dominated by transverse diffusion to one dominated by drifts. We show that this scenario explains not only the changes in spectral slope at the knee and at the second knee, but can also account for the main characteristics of the observed energy dependent anisotropy amplitude and phase of first harmonic in the energy range between $10^{15}$ and $10^{18}$ eV. This provides a useful handle to distinguish this diffusion/drift model from other scenarios proposed to explain the knee in the spectrum.Comment: 13 pages, 3 figures; revised version with minor changes. To appear in JCA

Comparative study of an Eden model for the irreversible growth of spins and the equilibrium Ising model

The Magnetic Eden Model (MEM) with ferromagnetic interactions between nearest-neighbor spins is studied in $(d+1)-$dimensional rectangular geometries for $d = 1,2$. In the MEM, magnetic clusters are grown by adding spins at the boundaries of the clusters. The orientation of the added spins depends on both the energetic interaction with already deposited spins and the temperature, through a Boltzmann factor. A numerical Monte Carlo investigation of the MEM has been performed and the results of the simulations have been analyzed using finite-size scaling arguments. As in the case of the Ising model, the MEM in $d = 1$ is non-critical (only exhibits an ordered phase at $T= 0$). In $d = 2$ the MEM exhibits an order-disorder transition of second-order at a finite temperature. Such transition has been characterized in detail and the relevant critical exponents have been determined. These exponents are in agreement (within error bars) with those of the Ising model in 2 dimensions. Further similarities between both models have been found by evaluating the probability distribution of the order parameter, the magnetization and the susceptibility. Results obtained by means of extensive computer simulations allow us to put forward a conjecture which establishes a nontrivial correspondence between the MEM for the irreversible growth of spins and the equilibrium Ising model. This conjecture is certainly a theoretical challenge and its confirmation will contribute to the development of a framework for the study of irreversible growth processes.Comment: 21 pages, 11 figure

A study on the sharp knee and fine structures of cosmic ray spectra

The paper investigates the overall and detailed features of cosmic ray (CR) spectra in the knee region using the scenario of nuclei-photon interactions around the acceleration sources. Young supernova remnants can be the physical realities of such kind of CR acceleration sites. The results show that the model can well explain the following problems simultaneously with one set of source parameters: the knee of CR spectra and the sharpness of the knee, the detailed irregular structures of CR spectra, the so-called "component B" of Galactic CRs, and the electron/positron excesses reported by recent observations. The coherent explanation serves as evidence that at least a portion of CRs might be accelerated at the sources similar to young supernova remnants, and one set of source parameters indicates that this portion mainly comes from standard sources or from a single source.Comment: 13 pages, 4 figures, accepted for publication in SCIENCE CHINA Physics, Mechanics & Astronomy

Superprocesses as models for information dissemination in the Future Internet

Future Internet will be composed by a tremendous number of potentially interconnected people and devices, offering a variety of services, applications and communication opportunities. In particular, short-range wireless communications, which are available on almost all portable devices, will enable the formation of the largest cloud of interconnected, smart computing devices mankind has ever dreamed about: the Proximate Internet. In this paper, we consider superprocesses, more specifically super Brownian motion, as a suitable mathematical model to analyse a basic problem of information dissemination arising in the context of Proximate Internet. The proposed model provides a promising analytical framework to both study theoretical properties related to the information dissemination process and to devise efficient and reliable simulation schemes for very large systems

Results from the KASCADE, KASCADE-Grande, and LOPES experiments

The origin of high-energy cosmic rays in the energy range from 10^14 to 10^18 eV is explored with the KASCADE and KASCADE-Grande experiments. Radio signals from air showers are measured with the LOPES experiment. An overview on results is given.Comment: Talk at The ninth International Conference on Topics in Astroparticle and Underground Physics, TAUP 2005, Zaragoza, September 10-14, 200

Anomalous behavior of the irreversible magnetization and time relaxation in YBa2_2Cu3_3O7_7 single crystals with splayed tracks

We have studied the angular dependence of the irreversible magnetization and its time relaxation in YBa$_2$Cu$_3$O$_7$ single crystals with one or two families of columnar defects inclined with respect to the c-axis. At high magnetic fields, the magnetization shows the usual maximum centered at the mean tracks' orientation and an associated minimum in the normalized relaxation rate. In contrast, at low fields we observe an anomalous local minimum in the magnetization and a maximum in the relaxation rate. We present a model to explain this anomaly based on the slowing down of the creep processes arising from the increase of the vortex-vortex interactions as the applied field is tilted away from the mean tracks' direction.Comment: 15 pages, 6 figures. Submitted to Phys. Rev .