105 research outputs found
Minimum quadratic helicity states
Building on previous results on the quadratic helicity in
magnetohydrodynamics (MHD) we investigate particular minimum helicity states.
Those are eigenfunctions of the curl operator and are shown to constitute
solutions of the quasi-stationary incompressible ideal MHD equations. We then
show that these states have indeed minimum quadratic helicity.Comment: 13 pages, 2 figure
Calculations for the Practical Applications of Quadratic Helicity in MHD
For the quadratic helicity Ï(2), we present a generalization of the Arnol'd inequality which relates the magnetic energy to the quadratic helicity, which poses a lower bound. We then introduce the quadratic helicity density using the classical magnetic helicity density and its derivatives along magnetic field lines. For practical purposes, we also compute the flow of the quadratic helicity and show that for an α2-dynamo setting, it coincides with the flow of the square of the classical helicity. We then show how the quadratic helicity can be extended to obtain an invariant even under compressible deformations. Finally, we conclude with the numerical computation of Ï(2) which show cases the practical usage of this higher order topological invariant
Ideal relaxation of the Hopf fibration
Ideal MHD relaxation is the topology-conserving reconfiguration of a magnetic
field into a lower energy state where the net force is zero. This is achieved
by modeling the plasma as perfectly conducting viscous fluid. It is an
important tool for investigating plasma equilibria and is often used to study
the magnetic configurations in fusion devices and astrophysical plasmas. We
study the equilibrium reached by a localized magnetic field through the
topology conserving relaxation of a magnetic field based on the Hopf fibration
in which magnetic field lines are closed circles that are all linked with one
another. Magnetic fields with this topology have recently been shown to occur
in non-ideal numerical simulations. Our results show that any localized field
can only attain equilibrium if there is a finite external pressure, and that
for such a field a Taylor state is unattainable. We find an equilibrium plasma
configuration that is characterized by a lowered pressure in a toroidal region,
with field lines lying on surfaces of constant pressure. Therefore, the field
is in a Grad-Shafranov equilibrium. Localized helical magnetic fields are found
when plasma is ejected from astrophysical bodies and subsequently relaxes
against the background plasma, as well as on earth in plasmoids generated by
e.g.\ a Marshall gun. This work shows under which conditions an equilibrium can
be reached and identifies a toroidal depression as the characteristic feature
of such a configuration
HCC development is associated to peripheral insulin resistance in a mouse model of NASH
NAFLD is the most common liver disease worldwide but it is the potential evolution to NASH and eventually to hepatocellular carcinoma (HCC), even in the absence of cirrhosis, that makes NAFLD of such clinical importance. Aim: we aimed to create a mouse model reproducing the pathological spectrum of NAFLD and to investigate the role of possible co-factors in promoting HCC. Methods: mice were treated with a choline-deficient L-amino-acid-defined-diet (CDAA) or its control (CSAA diet) and subjected to a low-dose i.p. injection of CCl 4 or vehicle. Insulin resistance was measured by the euglycemic-hyperinsulinemic clamp method. Steatosis, fibrosis and HCC were evaluated by histological and molecular analysis. Results: CDAA-treated mice showed peripheral insulin resistance at 1 month. At 1-3 months, extensive steatosis and fibrosis were observed in CDAA and CDAA+CCl4 groups. At 6 months, equal increase in steatosis and fibrosis was observed between the two groups, together with the appearance of tumor. At 9 months of treatment, the 100% of CDAA+ CCl4 treated mice revealed tumor versus 40% of CDAA mice. Insulin-like Growth Factor-2 (IGF-2) and Osteopontin (SPP-1) were increased in CDAA mice versus CSAA. Furthermore, Immunostaining for p-AKT, p-c-Myc and Glypican-3 revealed increased positivity in the tumors. Conclusions: the CDAA model promotes the development of HCC from NAFLD-NASH in the presence of insulin resistance but in the absence of cirrhosis. Since this condition is increasingly recognized in humans, our study provides a model that may help understanding mechanisms of carcinogenesis in NAFLD. © 2014 De Minicis et al
Simulations of galactic dynamos
We review our current understanding of galactic dynamo theory, paying
particular attention to numerical simulations both of the mean-field equations
and the original three-dimensional equations relevant to describing the
magnetic field evolution for a turbulent flow. We emphasize the theoretical
difficulties in explaining non-axisymmetric magnetic fields in galaxies and
discuss the observational basis for such results in terms of rotation measure
analysis. Next, we discuss nonlinear theory, the role of magnetic helicity
conservation and magnetic helicity fluxes. This leads to the possibility that
galactic magnetic fields may be bi-helical, with opposite signs of helicity and
large and small length scales. We discuss their observational signatures and
close by discussing the possibilities of explaining the origin of primordial
magnetic fields.Comment: 28 pages, 15 figure, to appear in Lecture Notes in Physics "Magnetic
fields in diffuse media", Eds. E. de Gouveia Dal Pino and A. Lazaria
Effects of fieldline topology on energy propagation in the corona
We study the effect of photospheric footpoint motions on magnetic field
structures containing magnetic nulls. The footpoint motions are prescribed on
the photospheric boundary as a velocity field which entangles the magnetic
field. We investigate the propagation of the injected energy, the conversion of
energy, emergence of current layers and other consequences of the non-trivial
magnetic field topology in this situation. These boundary motions lead
initially to an increase in magnetic and kinetic energy. Following this, the
energy input from the photosphere is partially dissipated and partially
transported out of the domain through the Poynting flux. The presence of
separatrix layers and magnetic null-points fundamentally alters the propagation
behavior of disturbances from the photosphere into the corona. Depending on the
field line topology close to the photosphere, the energy is either trapped or
free to propagate into the corona.Comment: 14 pages, 15 figure
Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth
BACKGROUND/AIMS:
Incidence of cholangiocarcinoma is increasing worldwide, yet remaining highly aggressive and with poor prognosis. The mechanisms that drive cholangiocyte transition towards malignant phenotype are obscure. Cholangiocyte benign proliferation is subjected to a self-limiting mechanism based on the autocrine release of endogenous opioid peptides. Despite the presence of both, ligands interact with delta opioid receptor (OR), but not with microOR, with the consequent inhibition of cell growth. We aimed to verify whether cholangiocarcinoma growth is associated with failure of opioidergic regulation of growth control.
METHODS:
We evaluated the effects of OR selective agonists on cholangiocarcinoma cell proliferation, migration and apoptosis. Intracellular signals were also characterised.
RESULTS:
Activation of microOR, but not deltaOR, increases cholangiocarcinoma cell growth. Such an effect is mediated by ERK1/2, PI3K and Ca(2+)-CamKIIalpha cascades, but not by cAMP/PKA and PKCalpha. microOR activation also enhances cholangiocarcinoma cell migration and reduces death by apoptosis. The anti-apoptotic effect of microOR was PI3K dependent.
CONCLUSIONS:
Our data indicate that cholangiocarcinoma growth is associated with altered opioidergic regulation of cholangiocyte biology, thus opening new scenarios for future surveillance or early diagnostic strategies for cholangiocarcinoma
Do current and magnetic helicities have the same sign?
Current helicity, H c , and magnetic helicity, H m , are two main quantities used to characterize magnetic fields. For example, such quantities have been widely used to characterize solar active regions and their ejecta (magnetic clouds). It is commonly assumed that H c and H m have the same sign, but this has not been rigorously addressed beyond the simple case of linear force-free fields. We aim to answer whether H m H c â„ 0 in general, and whether it is true over some useful set of magnetic fields. This question is addressed analytically and with numerical examples. The main focus is on cylindrically symmetric straight flux tubes, referred to as flux ropes (FRs), using the relative magnetic helicity with respect to a straight (untwisted) reference field. Counterexamples with H m H c < 0 have been found for cylindrically symmetric FRs with finite plasma pressure, and for force-free cylindrically symmetric FRs in which the poloidal field component changes direction. Our main result is a proof that H m H c â„ 0 is true for force-free cylindrically symmetric FRs where the toroidal field and poloidal field components are each of a single sign, and the poloidal component does not exceed the toroidal component. We conclude that the conjecture that current and magnetic helicities have the same sign is not true in general, but it is true for a set of FRs of importance to coronal and heliospheric physics
Current status of turbulent dynamo theory: From large-scale to small-scale dynamos
Several recent advances in turbulent dynamo theory are reviewed. High
resolution simulations of small-scale and large-scale dynamo action in periodic
domains are compared with each other and contrasted with similar results at low
magnetic Prandtl numbers. It is argued that all the different cases show
similarities at intermediate length scales. On the other hand, in the presence
of helicity of the turbulence, power develops on large scales, which is not
present in non-helical small-scale turbulent dynamos. At small length scales,
differences occur in connection with the dissipation cutoff scales associated
with the respective value of the magnetic Prandtl number. These differences are
found to be independent of whether or not there is large-scale dynamo action.
However, large-scale dynamos in homogeneous systems are shown to suffer from
resistive slow-down even at intermediate length scales. The results from
simulations are connected to mean field theory and its applications. Recent
work on helicity fluxes to alleviate large-scale dynamo quenching, shear
dynamos, nonlocal effects and magnetic structures from strong density
stratification are highlighted. Several insights which arise from analytic
considerations of small-scale dynamos are discussed.Comment: 36 pages, 11 figures, Spa. Sci. Rev., submitted to the special issue
"Magnetism in the Universe" (ed. A. Balogh
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