Construccion de un prototipo sobre la base de indicadores de gestion y tecnologia OLAP para el apoyo a la toma de decisiones en el area de operacion comercial en Aguas Nuevo Sur del Maule S.A

89 p.La Empresa Aguas Nuevo Sur del Maule S.A. (ANSMI S.A.), como toda empresa, determina objetivos estratégicos para guiar su gestión, los cuales deben estar directamente relacionados con los objetivos de cada área funcional. Dentro de la organización de la empresa, se encuentra el área de Servicio al Cliente la que se divide en dos sub-áreas que son: Subgerencia de Operación Comercial y Subgerencia de Desarrollo Comercial. El presente proyecto se desarrolla sobre la Subgerencia de Operación Comercial. Ella utiliza como base los objetivos estratégicos definidos por la empresa para definir sus propias metas. El cumplimiento de estas, se mide a través de un conjunto de Indicadores de Gestión que se enmarca dentro de un proceso de Control de Gestión, el que permite monitorear el proceso de Plantación Estratégica y determinar las desviaciones para poder tomar las medidas correctivas que correspondan. La finalidad del proyecto consiste en desarrollar el prototipo de un sistema informático de apoyo a la toma de decisiones que permita obtener el conjunto de indicadores conducentes a evaluar el cumplimiento de los objetivos planteados para el área de Operación Comercial en ANSM S.A. El conjunto de indicadores debe conformar una familia coherente de criterios, la cual cumpla con las condiciones de: Exhaustividad, Cohesión y No Redundancia (Bernard, 1996). Con ello se espera que el conjunto de indicadores sea suficiente para medir el cumplimiento de los objetivos del área en cuestión, para tomar las decisiones necesarias que permitan lograr los resultados deseados

Heptapeptide HP3 acts as a potent inhibitor of experimental imiquimod-induced murine psoriasis and impedes the trans-endothelial migration of mononuclear cells

During the progression of psoriatic lesions, abundant cellular infiltration of myeloid cells, such as macrophages and activated dendritic cells, occurs in the skin and the infiltrating cells interact with naive lymphoid cells to generate a T helper (Th)1 and Th17 environment. Therapies to treat psoriasis include phototherapy, non-steroidal and steroidal drugs, as well as antibodies to block tumor necrosis factor-alpha, interleukin (IL)-17-A and IL-12/IL-23, which all focus on decreasing the proinflammatory hallmark of psoriasis. The present study obtained the heptapeptide HP3 derived from phage display technology that blocks mononuclear cell adhesion to endothelial cells and inhibits trans-endothelial migrationin vitro. The activity of the heptapeptide in a murine model of psoriasis was also assessed, which indicated that early administration inhibited the development of psoriatic lesions. Therefore, the results suggested that HP3 may serve as a potential therapeutic target for psoriasis.Funding Agencies|IPN-Multidisciplinary Projects [SIP-1773, SIP-20149]; CONACyTConsejo Nacional de Ciencia y Tecnologia (CONACyT); BEIFI-IPN</p

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field