A Commentary on Bison and Cultural Restoration: Partnership Between the National Wildlife Federation and the Intertribal Bison Cooperative

In January 1997 the National Wildlife Federation and the InterTribal Bison Cooperative signed a memorandum of understanding formally recognizing our common goals of ending the slaughter of Yellowstone bison and working to repatriate buffalo to Native American reservations. It was the first time a formal relationship had ever been established between Native Americans and a national conservation organization. The partnership had two goals. The first goal was to reestablish management of North American bison as one of the premier wildlife species of the West, by restoring bison to those tribal and public land habitats capable of supporting their long-term survival. The second goal was to enhance the availability of wild bison to Native Americans for cultural and subsistence uses. Our partnership has been a rallying point for bison advocates and illustrates the importance of repatriating bison to tribal lands. The partnership also presented opportunities for Native Americans to demonstrate their management capabilities and to affirm the importance of bison to the health of Indian people and the vitality of their culture. Our work together has opened up many new conservation avenues. One example is the National Wildlife Federation\u27s recent involvement with the newly established InterTribal Prairie Ecosystem Restoration Consortium, assisting with the development of prairie dog management plans on Indian reservations. Here we summarize the results of our partnership and look to the future of conservation and restoration of natural resources on tribal lands

CRH – Approches historiques des mondes contemporains (AhMoC)

Stéphane Audoin-Rouzeau, Marc Olivier Baruch, Christophe Prochasson, Paul-André Rosental, directeurs d’étudesLaura Lee Downs, directrice d’étudesJordi Canal, maître de conférencesVincent Duclert, professeur agrégéMarie-Laurence Netter, ingénieure d’étudesAlain Chatriot, chargé de recherche au CNRSPerrine Simon-Nahum, chargée de recherche au CNRS Histoire politique du contemporain Le programme du séminaire reposait cette année sur une série d’interrogations générales relatives à la recherche e..

Approches historiques des mondes contemporains – AhMoC

Stéphane Audoin-Rouzeau, Marc Olivier Baruch, Jacques Julliard, Laura Lee Downs, Christophe Prochasson, Paul-André Rosental, directeurs d’étudesIsabelle Backouche, Jordi Canal, maîtres de conférencesVincent Duclert, professeur agrégéMarie-Laurence Netter, ingénieur d’étudesAlain Chatriot et Perrine Simon-Nahum, chargés de recherche au CNRS L’histoire politique. État des lieux Cette année, le séminaire s’est concentré sur l’historiographie de la gauche. En 2003-2004, on s’était penché sur les ..

Montlaurès et son territoire à l'âge du Fer

Identifiant de l'opération archéologique : Date de l'opération : 1998 - 2000 (FP) ; 1998 (PT) ; 1996 (PT) ; 1991 - 1995 (FP) ; 1960 - 1964 (SD) Inventeur(s) : Chazelles Claire-Anne de (CNRS) ; Héléna Philippe ; Giry Joseph ; Solier Yves ; Mauné Stéphane ; Sanchez Corinne ; Ropiot Véronique ; Ugolini Daniela ; Genis-Armada Maria-Theresa ; Canal-Barcalà David ; Sternberg Myriam ; Chabal Lucie ; Grau Marina (Étudiant DEA et doctorant) ; Rescanières Sébastien (Étudiant DEA et doctorant) ; Jorda ..

Oxidative stress does not play a primary role in the toxicity induced with clinical doses of doxorubicin in myocardial H9c2 cells

International audienceThe implication of oxidative stress as primary mechanism inducing doxorubicin (DOX) cardiotoxicity is still questionable as many in vitro studies implied supra-clinical drug doses or unreliable methodologies for reactive oxygen species (ROS) detection. The aim of this study was to clarify whether oxidative stress is involved in compliance with the conditions of clinical use of DOX, and using reliable tools for ROS detection. We examined the cytotoxic mechanisms of 2 μM DOX 1 day after the beginning of the treatment in differentiated H9c2 rat embryonic cardiac cells. Cells were exposed for 2 or 24 h with DOX to mimic a single chronic dosage or to favor accumulation, respectively. We found that apoptosis was prevalent in cells exposed for a short period with DOX: cells showed typical hallmarks as loss of anchorage ability, mitochondrial hyperpolarization followed by the collapse of mitochondrial activity, and nuclear condensation. Increasing the exposure period favored a shift to necrosis as the cells preferentially exhibited early DNA impairment and nuclear swelling. In either case, measuring the fluorescence lifetime of 1-pyrenebutyric acid or the intensities of dihydroethidium or amplex red showed a consistent pattern in ROS production which was a slight increased level far from representative of an oxidative stress. Moreover, pre-treatment with dexrazoxane provided a cytoprotective effect although it failed to detoxify ROS. Our data support that oxidative stress is unlikely to be the primary mechanism of DOX cardiac toxicity in vitro

Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum

International audienceBackgroun

Bages-Sigean and Canet-St Nazaire lagoons (France): physico-chemical characteristics and contaminant concentrations (Cu, Cd, PCBs and PBDEs) as environmental quality of water and sediment

International audienceEnvironmental characteristics in water and sediments of two contrasted coastal Mediterranean lagoons, Bages-Sigean and Canet-St Nazaire, were measured over a three season survey. The urban pollution (treatment plant discharges) is very important in Canet-St Nazaire lagoon reflecting untreated sewages, while in Bages-Sigean, the northern part appears more impacted due to larger anthropogenic inputs. Dissolved Cd concentrations are on the whole similar in both lagoons, whereas Cu concentrations are by far higher in lagoon Canet-St Nazaire. Cu concentrations appear to be highly dependent on dissolved organic carbon whereas salinity seems to control Cd variations. Concerning the sediments, the confined northern part of lagoon Bages-Sigean shows organic carbon and total nitrogen enrichment whereas lipid concentrations are much higher in the Canet-St Nazaire lagoon. Cu complexation seems to be strongly related to organic matter as evidenced by the two significant positive relationships, on one hand between Cu and organic carbon, and on the other hand, between Cu and lipids. On the contrary, Cd concentrations appear to be mainly controlled by carbonates. PCBs and PBDEs were detected only in sediments and show relatively low concentrations compared to similar lagoon environments. Regarding the sediment quality guidelines, Cd, Cu and PCBs in both lagoons did not exceed any Probable Effect Concentration (PEC)