Growth, volatility and political instability: Non-linear time-series evidence for Argentina, 1896-2000

What is the relationship between economic growth and its volatility? Does political instability affect growth directly or indirectly, through volatility? This paper tries to answer such questions using a power-ARCH framework with annual time series data for Argentina from 1896 to 2000. We show that while assassinations and strikes (what we call “informal” political instability) have a direct negative effect on economic growth, “formal” political instability (constitutional and legislative changes) has an indirect (through volatility) negative impact. We also find preliminary support for the idea that while the effects of “formal” instability are stronger in the long-run, those of “informal” instability are stronger in the short-run

O POTENCIAL DE MINAS GERAIS NO DESENVOLVIMENTO DA COMPETÊNCIA INTERCULTURAL DOS ALUNOS DE PLAc

Em um contexto de globalização caracterizado por intensos fluxos migratórios, temos presenciado uma reestruturação nos projetos de ensino de Língua Não Materna (LNM), cada vez mais alicerçados em princípios da internacionalização da educação. As configurações que temos hoje, estão estruturadas para além de uma abordagem linguístico-discursiva e se orientam por meio do desenvolvimento da competência intercultural dos aprendizes. Em meio a esse cenário, o presente artigo pretende refletir sobre a dinâmica de funcionamento do Português como Língua de Acolhimento (PLAc) no Brasil, especificamente no CEFET/MG, a partir da exploração da tríade em que o mesmo é elaborado: dimensão internacional, conhecimentos globais, contexto local. Tal reflexão será feita a partir de uma prática realizada com os alunos do PLAc do CEFET/MG, no 2º semestre de 2018, intitulada Esquema da mineiridade – uma atividade que  articulava conteúdos global e local para, evidenciando a diversidade e a produção de saberes em diferentes culturas, ensinar o português. A prática superou as expectativas iniciais, uma vez que além dos avanços no processo de aprendizagem da Língua Portuguesa, pudemos observar movimentações nos posicionamentos discursivos em relação à cultura do outro

Ganglioglioma Intraventricular Diagnosticado por Hemorragia Espontânea

Intraventricular gangliogliomas presenting with spontaneous hemorrhage are rare. Due to high density of important tracts lateral to the ventricular atrium, the intraparietal trans sulcal approach is a good option to remove lesions in this location. These tracts are displaced and sometimes destroyed by the presence of large masses. A 33-year-old male presented with a sudden headache and a generalized seizure. He had a left visual field hemianopia and left visual field neglect. Brain computer tomography and magnetic resonance imaging revealed a hemorrhagic tumor located in his right atrium. With the help of tractography an optimal corridor to the tumor through the intraparietal sulcus was planned. Gross total removal of a ganglioglioma was possible with recovery of visual impairment and control of epilepsy. The efficacy in using tractography as a planning tool for safe tumor removal is demonstrated with clinical, imagiological and histological data, and a surgical video.info:eu-repo/semantics/publishedVersio

EFECTO DE LA TEMPERATURA Y TIEMPO DE FRITURA EN LA TEXTURA Y COLOR DE UN CHIP DE OCA (Oxalis Tuberosa)

El presente trabajo tuvo como propósito elaborar un chip de oca, teniendo como variables la temperatura (160-180°C) y tiempo (30-90 segundos) de fritura. Se aplicó un diseño factorial 3k, con tres niveles para cada factor teniendo como variables depediente la textura y luminosidad del chip de oca. La Oca (Oxalis Tuberosa) tuvo las siguientes características fisicoquímicas, humedad (%) de 79.14±1.21, proteínas (%) de 1.04±0.95, extracto etéreo (%) de 0.89±0.15, cenizas (%) de 1.01±0.08 y pH de 4.52±0.21. El valor óptimo de las variables aplicando la metodología de función deseada fueron temperatura de 172°C y tiempo de 45 segundos de fritura, con respuestas óptimas de textura de 2.305 mJ y 77.3815 de luminosidad. El chip de Oca (Oxalis Tuberosa) tuvo las siguientes características fisicoquímicas, humedad (%) de 6.90 ±0.37, Proteínas (%) de 5.37 ±0.26, extracto etéreo (%) de 1.73 ±0.05, cenizas (%) de 3.75 ±0.09, textura (mJ) de 2.31 ±0.01 y luminosidad 77.13 ±0.32

DA INADEQUAÇÃO PROCEDIMENTAL DO ART. 285-A DO CPC (THE ART OF PROCEDURAL INADEQUATE. 285-A OF CPC)

RESUMO O advento do dispositivo 285-A do Código Processo Civil, promovido pela Lei 11.277, de 07 de fevereiro de 2006, trouxe consigo a discordância na notória falta de técnica do legislador sobre a redação do dispositivo, gerando controvérsias sobre a sua constitucionalidade. É de convir-se que o artigo é constitucional, porém o seu procedimento é inadequado, não fere nenhum princípio que rege o Estado Democrático de Direito, sendo necessário uma interpretação gramatical. Contudo, vale ressaltar que o dispositivo inovador se tornou célere e eficaz, sendo objeto de ação de inconstitucionalidade 3.695/06, ainda não julgada, proposta pela a OAB. Todavia, no percurso da análise da ADIN, o ministro Cezar Peluzo permitiu o Amicus Curiae (Anexo), proposto pelo IBDI, afirmando a constitucionalidade do art.285-A. PALAVRAS-CHAVE: inadequação procedimental, dispositivo 285-A do CPC. ABSTRACT The advent of the device 285-A of the Civil Procedure Code, sponsored by Law 11.277, of February 7, 2006, brought the disagreement in the notorious lack of technique of the legislature on the wording of the device, generating controversy over its constitutionality. We may agree that the article is constitutional, but his procedure is inadequate, does not violate any principle governing the democratic state, and it takes a grammatical interpretation. However, it is noteworthy that the innovative device has become swift and effective, the subject of constitutional challenge 3.695/06, yet to be decided, as proposed by the OAB. However, in the course of analysis of ADIN, Minister Cezar Peluzo allowed Amicus Curiae (Annex), proposed by IBDI, affirming the constitutionality of art.285-A. KEYWORDS: inadequate procedural, device 285-A of the CPC

Excellent outcomes of laparoscopic esophagomyotomy for achalasia in patients older than 60 years of age

The effectiveness of an esophagomyotomy for dysphagia in elderly patients with achalasia has been questioned. This study was designed to provide an answer. A total of 162 consecutive patients with achalasia who had a laparoscopic myotomy and Dor fundoplication and who were available for follow-up interview were divided by age: <60 years (range, 14–59; 118 patients), and ≥60 years (range, 60–93; 44 patients). Primary outcome measures were severity of dysphagia, regurgitation, heartburn, and chest pain before and after the operation as assessed on a four-point Likert scale, and the need for postoperative dilatation or revisional surgery. Follow-up averaged 64 months. Older patients had less dysphagia (mean score 3.6 vs. 3.9; P < 0.01) and less chest pain (1.0 vs. 1.8; P < 0.01). Regurgitation (3.0 vs. 3.2; P = not significant (NS)) and heartburn (1.6 vs. 2.0, P = NS) were similar. Older patients were no different in degree of esophageal dilation, manometric findings, number of previous pneumatic dilatations, or previous botulinum toxin therapy. None of the older patients had previously had an esophagomyotomy, whereas 14% of younger patients had (P < 0.01). After laparoscopic myotomy, older patients had better relief of dysphagia (mean score 1.0 vs 1.6; P < 0.01), less heartburn (0.8 vs. 1.1; P = 0.03), and less chest pain (0.2 vs. 0.8, P < 0.01). Complication rates were similar. Older patients did not require more postoperative dilatations (22 patients vs. 10 patients; P = 0.7) or revisional surgery for recurrent or persistent symptoms (3 vs. 1 patients; P = 0.6). Satisfaction scores did not differ, and more than 90% of patients in both groups said in retrospect they would have undergone the procedure if they had known beforehand how it would turn out. This retrospective review with long follow-up supports laparoscopic esophagomyotomy as first-line therapy in older patients with achalasia. They appeared to benefit even more than younger patients

Benchmarking of human Y-chromosomal haplogroup classifiers with whole-genome and whole-exome sequence data

In anthropological, medical, and forensic studies, the nonrecombinant region of the human Y chromosome (NRY) enables accurate reconstruction of pedigree relationships and retrieval of ancestral information. Using high-throughput sequencing (HTS) data, we present a benchmarking analysis of command-line tools for NRY haplogroup classification. The evaluation was performed using paired Illumina data from whole-genome sequencing (WGS) and whole-exome sequencing (WES) experiments from 50 unrelated donors. Additionally, as a validation, we also used paired WGS/WES datasets of 54 individuals from the 1000 Genomes Project. Finally, we evaluated the tools on data from third-generation HTS obtained from a subset of donors and one reference sample. Our results show that WES, despite typically offering less genealogical resolution than WGS, is an effective method for determining the NRY haplogroup. Y-LineageTracker and Yleaf showed the highest accuracy for WGS data, classifying precisely 98% and 96% of the samples, respectively. Yleaf outperforms all benchmarked tools in the WES data, classifying approximately 90% of the samples. Yleaf, Y-LineageTracker, and pathPhynder can correctly classify most samples (88%) sequenced with third-generation HTS. As a result, Yleaf provides the best performance for applications that use WGS and WES. Overall, our study offers researchers with a guide that allows them to select the most appropriate tool to analyze the NRY region using both second- and third-generation HTS data

A two step Bayesian approach for genomic prediction of breeding values

<p>Abstract</p> <p>Background</p> <p>In genomic models that assign an individual variance to each marker, the contribution of one marker to the posterior distribution of the marker variance is only one degree of freedom (df), which introduces many variance parameters with only little information per variance parameter. A better alternative could be to form clusters of markers with similar effects where markers in a cluster have a common variance. Therefore, the influence of each marker group of size <it>p </it>on the posterior distribution of the marker variances will be <it>p </it>df.</p> <p>Methods</p> <p>The simulated data from the 15^thQTL-MAS workshop were analyzed such that SNP markers were ranked based on their effects and markers with similar estimated effects were grouped together. In step 1, all markers with minor allele frequency more than 0.01 were included in a SNP-BLUP prediction model. In step 2, markers were ranked based on their estimated variance on the trait in step 1 and each 150 markers were assigned to one group with a common variance. In further analyses, subsets of 1500 and 450 markers with largest effects in step 2 were kept in the prediction model.</p> <p>Results</p> <p>Grouping markers outperformed SNP-BLUP model in terms of accuracy of predicted breeding values. However, the accuracies of predicted breeding values were lower than Bayesian methods with marker specific variances.</p> <p>Conclusions</p> <p>Grouping markers is less flexible than allowing each marker to have a specific marker variance but, by grouping, the power to estimate marker variances increases. A prior knowledge of the genetic architecture of the trait is necessary for clustering markers and appropriate prior parameterization.</p

Possible Race and Gender Divergence in Association of Genetic Variations with Plasma von Willebrand Factor: A Study of ARIC and 1000 Genome Cohorts

The synthesis, secretion and clearance of von Willebrand factor (VWF) are regulated by genetic variations in coding and promoter regions of the VWF gene. We have previously identified 19 single nucleotide polymorphisms (SNPs), primarily in introns that are associated with VWF antigen levels in subjects of European descent. In this study, we conducted race by gender analyses to compare the association of VWF SNPs with VWF antigen among 10,434 healthy Americans of European (EA) or African (AA) descent from the Atherosclerosis Risk in Communities (ARIC) study. Among 75 SNPs analyzed, 13 and 10 SNPs were associated with VWF antigen levels in EA male and EA female subjects, respectively. However, only one SNP (RS1063857) was significantly associated with VWF antigen in AA females and none was in AA males. Haplotype analysis of the ARIC samples and studying racial diversities in the VWF gene from the 1000 genomes database suggest a greater degree of variations in the VWF gene in AA subjects as compared to EA subjects. Together, these data suggest potential race and gender divergence in regulating VWF expression by genetic variations