MIGRAÇÃO DO CANAL NA PLANÍCIE FLUVIAL DO RIO CLARO – BACIA DO RIO ARAGUAIA, GOIÁS, BRASIL

Ambientes produzidos pela migração de meandros são altamente biodiversos. Erosão e deposição são processos inerentes em rios meândricos. Este trabalho identifica os processos de migração dos meandros em dois trechos do baixo rio Claro, afluente do rio Araguaia, entre 1988 e 2012, situados entre trechos retilíneos com forte controle estrutural. Verificou-se uma migração intensa, com predomínio do processo de expansão de meandros e ambienteis flúvio-lacustres provenientes do abandono de meandros

Urinary pyridinoline cross-links as biomarkers of osteogenesis imperfecta.

Osteogenesis imperfecta (OI) is a group of genetic heterogeneous connective tissue disorders characterized by increased bone fragility and susceptibility to fractures. Laboratory diagnosis relies on time-consuming and cost-intensive biochemical and molecular genetics analyses. Therefore, it is desirable to identify and establish new diagnostic markers for OI that are reliable, cost-effective and easily accessible. In our study we have identified the ratio of the urinary pyridinoline cross-links lysyl-pyridinoline and hydroxylysyl-pyridinoline as a promising, time- and cost-effective biomarker for osteogenesis imperfecta, that could be used furthermore to investigate cases of suspected non-accidental injury in infants

CFT/CFT interpolating RG flows and the holographic c-function

We consider holographic RG flows which interpolate between non-trivial ultra-violet (UV) and infra-red (IR) conformal fixed points. We study the ``superpotentials'' which characterize different flows and discuss their expansions near the fixed points. Then we focus on the holographic $c$-function as defined from the two-point function of the stress-energy tensor. We point out that the equation for the metric fluctuations in the background flow is equivalent to a scattering problem and we use this to obtain an expression for the $c$-function in terms of the associated Jost functions. We propose two explicit models that realize UV-IR flows. In the first example we consider a thin wall separating two AdS spaces with different radii, while in the second one the UV region is replaced with an asymptotically AdS space. We find that the holographic $c$-function obeys the expected properties. In particular it reduces to the correct -- nonzero -- central charge in the IR limit.Comment: 20 pages, discussion at the end of sec. 3 and sec. 4.1 change

Movimentação Vertical Do íon Potássio Em Neossolos Quartzarênicos Sob Cultivo Com Cana-de-açúcar

The objective of this work was to determine the vertical movement of the potassium ion in the profile of Quartzipsamment Entisols cultivated with sugarcane. Two experiments were conducted in field conditions. The first one consisted of an assessment of ion movement in the soil profile, down to 1.80-m depth, for two years, in an area cultivated with sugarcane and in another one under cerrado. The second one consisted of the evaluation of ion movement to a depth of 1.00 m, under two water regimes: Natural and controlled. In the experiment under controlled conditions, evaluations were done with 0.5-m2 plots, delimited by galvanized sheets, receiving 80 kg ha-1 K2O followed by the addition of 1,200 mm of water. The area cropped with sugarcane showed greater soil organic matter content, greater pH, and, consequently, greater retention capacity of K+ in the superficial layers of the soil profile than the cerrado area. Moreover, in the area with sugarcane crop, the evaluation of K+ availability in the profile of the Quartzipsamment Entisol profile was affected by the adopted water regime (natural or controlled rainfall). Regardless of soil use, K+ moves rapidly through the soil profile.5191548155

Heavy metals and micronutrients in soils under dairy grazing right on top of the river Paranaíba basin in the state of Goiás, Brazil

In Brazil, the agricultural activity is among the most competitive sectors of national economy, in which milk production has a very significant contribution. Concern about environmental contamination by this activity is related to the fact that dairy cattle manure heavy metals present in the constitution; the creation of such animals in the grazing system directly questions the possibility of any contamination by these metals in the watery, area where these animals congregate at certain times of day for drinking water and where they defecate. This study aimed to evaluate the content of copper, iron, manganese, zinc, cadmium, lead and chromium in watery areas and in conservation areas (control) of 28 properties, grouped into six “otto-basins” forming the upper basin of the Paranaíba River in the State of Goiás. The simple soil samples were collected at three depths (0-10, 10-20 and 20-30 cm) obtained from such a composite sample for each depth in the areas watered and preserved. The analysis of PCA metals pollutants in soils watery areas analyzed did not indicate the occurrence of contamination in these environments when compared to the preserved area. Observed random distribution of average levels of metals in the three studied depths in all treatments, which complicates the definition of the potential for soil contamination by feces of dairy farming originated in watery areas, under rotational grazing.A preocupação quanto à contaminação do ambiente por meio da atividade leiteira está relacionada ao fato dos dejetos destes bovinos apresentarem metais poluentes em sua constituição; na criação desses animais no sistema de pastejo direto questiona-se a possibilidade da ocorrência de contaminação por estes metais nas aguadas, área onde esses animais se aglomeram em determinados períodos do dia para beberem água e onde defecam. O presente estudo objetivou avaliar os teores dos metais cobre, ferro, manganês, zinco, cádmio, chumbo e cromo em áreas de aguadas e em áreas preservadas (testemunha) de 28 propriedades, agrupadas em seis Ottobacias hidrográficas formadoras do alto da bacia do Rio Paranaíba, no Estado de Goiás. As amostras simples de solos foram coletadas em três profundidades (0-10, 10-20 e 20-30 cm), a partir destas foram obtidas uma amostra composta para cada profundidade nas áreas de aguadas e preservadas. Pela análise de PCA os metais poluentes analisados nos solos de aguada não indicou a ocorrência de contaminação nestes ambientes quando comparados à área preservada. A distribuição aleatória dos teores médios dos metais nas três profundidades estudadas em todos os tratamentos dificulta a definição do potencial de contaminação do solo pelos dejetos originados da atividade leiteira em áreas de aguadas, sob pastejo direto3052582590Alvarenga, M.I.N., Davide, A.C., Características físicas e químicas de um Latossolo Vermelho-Escuro e a sustentabilidade de agroecossistemas (1999) Revista Brasileira de Ciência do Solo, 23 (4), pp. 933-942. , ViçosaByers, H.L., Cabrera, M.L., Matthews, M., Franklin, D.H., Andrae, J.G., Radcliffe, D.E., McCann, M.A., Calvert Jr, V.H., Phosphorus, sediment and Escherichia coli loads in unfenced streams of the Georgia Piedmont, USA (2005) Journal of Environmental Quality, 34 (11), pp. 2293-2300. , MadisonCorreia, P.R.M., Ferreira, M.M.C., Reconhecimento de padrões por métodos não supervisionados: Explorando procedimentos quimiométricos para o tratamento de dados analíticos (2007) Revista Química Nova, 30 (2), pp. 48-487. , São PauloEMBRAPA-Embrapa Informação Tecnológica, (2003) Pesquisa, desenvolvimento e inovação para o agronegócio brasileiro: Cenários 2002-2012, 92p. , Embrapa/Secretaria de Gestão e Estratégia. Brasília: Embrapa Informação TecnológicaIBGE-Instituto Brasileiro de Geografia e Estatística. Indicadores: Produção pecuária, , http://www.ibge.gov.br/home/mapa_site/mapa_site.php, Disponível em, Acesso em: 02 abr. 2012McGechan, M.B., Topp, C.F.E., Modelling environmental impacts of deposition of excreted nitrogen by grazing dairy cows (2004) Agriculture, Ecossystems e Environment, 103 (1), pp. 149-164. , AmsterdamMoura, M.C.S., Lopes, A.N.C., Moita, G.C., Moita Neto, J.M., Estudo multivariado de solos urbanos da cidade de Teresina (2006) Revista Química Nova, 29 (3), pp. 429-435. , São PauloOliver, M.A., Soil and human health: A review (1997) Journal Science Soil, 48 (4), pp. 573-592. , OxfordPereira, A.A., Borges, J.D., Leandro, W.M., Metais poluentes e micronutrientes no solo e em folhas de brachiaria decumbens às margens de rodovias (2010) Bioscience Journal, 26 (3), pp. 347-357. , UberlândiaPfafstetter, O., (1989) Classificação de bacias hidrográficas: Metodologia de codificação, 19p. , Rio de Janeiro, RJ: Departamento Nacional de Obras de Saneamento (DNOS), Trabalho não publicadoQuaggio, J.A., van Raij, B., Comparação de métodos rápidos para determinação da matéria orgânica em solo (1979) Revista Brasileira de. Ciência do Solo, 3 (3), pp. 184-187. , CampinasSEPIN-Superintendência de Pesquisa e Informação, (2012) Anuário Estatístico do Estado de Goiás-2005, , http://www.segplan.go.gov.br/, Disponível em: Acesso em: 22 junWijewardena, J.D.H., Gunaratne, S.P., Heavy metal in commonly used animal manure (2004) Annals of the Sri Lanka Dapartment of agriculture, 6 (2), pp. 245-253. , BombuwelaIn Brazil, the agricultural activity is among the most competitive sectors of national economy, in which milk production has a very significant contribution. Concern about environmental contamination by this activity is related to the fact that dairy cattle manure heavy metals present in the constitution; the creation of such animals in the grazing system directly questions the possibility of any contamination by these metals in the watery, area where these animals congregate at certain times of day for drinking water and where they defecate. This study aimed to evaluate the content of copper, iron, manganese, zinc, cadmium, lead and chromium in watery areas and in conservation areas (control) of 28 properties, grouped into six “otto-basins” forming the upper basin of the Paranaíba River in the State of Goiás. The simple soil samples were collected at three depths (0-10, 10-20 and 20-30 cm) obtained from such a composite sample for each depth in the areas watered and preserved. The analysis of PCA metals pollutants in soils watery areas analyzed did not indicate the occurrence of contamination in these environments when compared to the preserved area. Observed random distribution of average levels of metals in the three studied depths in all treatments, which complicates the definition of the potential for soil contamination by feces of dairy farming originated in watery areas, under rotational grazin

Structure-antifouling activity relationship and molecular targets of bio-inspired(Thio)xanthones

The development of alternative ecological and effective antifouling technologies is still challenging. Synthesis of nature-inspired compounds has been exploited, given the potential to assure commercial supplies of potential ecofriendly antifouling agents. In this direction, the antifouling activity of a series of nineteen synthetic small molecules, with chemical similarities with natural products, were exploited in this work. Six (4, 5, 7, 10, 15 and 17) of the tested xanthones showed in vivo activity toward the settlement of Mytilus galloprovincialis larvae (EC50: 3.53–28.60 µM) and low toxicity to this macrofouling species (LC50 > 500 µM and LC50/EC50: 17.42–141.64), and two of them (7 and 10) showed no general marine ecotoxicity (<10% of Artemia salina mortality) after 48 h of exposure. Regarding the mechanism of action in mussel larvae, the best performance compounds 4 and 5 might be acting by the inhibition of acetylcholinesterase activity (in vitro and in silico studies), while 7 and 10 showed specific targets (proteomic studies) directly related with the mussel adhesive structure (byssal threads), given by the alterations in the expression of Mytilus collagen proteins (PreCols) and proximal thread proteins (TMPs). A quantitative structure-activity relationship (QSAR) model was built with predictive capacity to enable speeding the design of new potential active compounds.This research was supported by national funds through FCT - Foundation for Science and Technology within the scope of UIDB/04423/2020 and UIDP/04423/2020 and under the project PTDC/AAG-TEC/0739/2014 (reference POCI-01-0145-FEDER-016793) supported through national funds provided by FCT and ERDF - European Regional Development Fund through the COMPETE - Programa Operacional Factores de Competitividade (POFC) programme and RIDTI - Reforçar a Investigação, o Desenvolvimento Tecnológico e a Inovação (project 9471) and the project NASCEM PTDC/BTA-BTA/31422/2017 (POCI-01-0145-FEDER-031422) also financed by FCT, COMPETE2020 and PORTUGAL2020

Identification of potential non-invasive biomarkers in diastrophic dysplasia.

Diastrophic dysplasia (DTD) is a recessive chondrodysplasia caused by pathogenic variants in the SLC26A2 gene encoding for a cell membrane sulfate/chloride antiporter crucial for sulfate uptake and glycosaminoglycan (GAG) sulfation. Research on a DTD animal model has suggested possible pharmacological treatment approaches. In view of future clinical trials, the identification of non-invasive biomarkers is crucial to assess the efficacy of treatments. Urinary GAG composition has been analyzed in several metabolic disorders including mucopolysaccharidoses. Moreover, the N-terminal fragment of collagen X, known as collagen X marker (CXM), is considered a real-time marker of endochondral ossification and growth velocity and was studied in individuals with achondroplasia and osteogenesis imperfecta. In this work, urinary GAG sulfation and blood CXM levels were investigated as potential biomarkers for individuals affected by DTD. Chondroitin sulfate disaccharide analysis was performed on GAGs isolated from urine by HPLC after GAG digestion with chondroitinase ABC and ACII, while CXM was assessed in dried blood spots. Results from DTD patients were compared with an age-matched control population. Undersulfation of urinary GAGs was observed in DTD patients with some relationship to the clinical severity and underlying SLC26A2 variants. Lower than normal CXM levels were observed in most patients, even if the marker did not show a clear pattern in our small patient cohort because CXM values are highly dependent on age, gender and growth velocity. In summary, both non-invasive biomarkers are promising assays targeting various aspects of the disorder including overall metabolism of sulfated GAGs and endochondral ossification

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

Acknowledgements This work was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01- 0145-FEDER-000013), the Fundação para a Ciência e Tecnologia (FCT) (SFRH/BD/136814/2018 to S.M.G., SFRH/BD/141127/2018 to C.D.O., PD/BD/137680/2018 to D.A., IF/00474/2014 to N.S.O., IF/01390/2014 to E.T., IF/00959/2014 to S.C., IF/00021/2014 to R.S., PTDC/SAU-SER/29635/2017 and CEECIND/04601/2017 to C.C., and CEECIND/03628/2017 to A.C.), the Institut Mérieux (Mérieux Research Grant 2017 to C.C.), and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Research Grant 2017 to A.C.). M.G.N. was supported by a Spinoza grant of the Netherlands Organization for Scientific Research. A.A.B. was supported by the Deutsche Forschungsgemeinschaft Collaborative Research Center/Transregio TR124 FungiNet (project A1). G.D.B. was funded by the Wellcome Trust (102705), the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1).Peer reviewedPublisher PD