Feasibility study of a combi-pv panel for greenhouse energy supply and water recovery by nightly radiation towards the sky

In southern European areas, characterized by high irradiation, the use of water for both evaporative cooling systems and hydroponic fertigation, represents a serious drawback for crop cultivation under cover. Water recovery systems seem to be an attractive solution, especially when they are integrated in the greenhouse construction. In this research, a feasibility study of applying a water recovery system driven by a combi-PV panel, in a semi-closed greenhouse was carried out. The prototype combi-PV panel was made by coupling an amorphous silicon panel with a sump stacked on the rear PV panel surface and filled with saline water. The system is driven by a cold-heat sink which is the PV panel itself. During night, the combi-PV panel exploits the radiative cooling of a ‘gray’ surface towards clear sky, chilling the water in the sump. In opposition, during day-time, the water in the sump is heated at a temperature higher than the environment. Thus, the water vapour will be condensing on the rear panel surface during night, being the warm air circulation facilitated by bouyancy effect. The evaluation of the system is in progress in order to assess the real amount of energy irradiated and consequently the water-drips to be collected on a proper surface inside the sump. The condensed water can be mixed with saline water to reduce the salinity and be used for fertigation

Vertical Greenery as Natural Tool for Improving Energy Efficiency of Buildings

The European Construction Sector Observatory outlined that green building envelopes as green roofs and walls contribute to the reduction of energy demand and CO2 emissions due to the air conditioning in summer periods, and the mitigation of heat islands in urban areas. For this reason, the understanding about the contribution of urban greening infrastructures on buildings to sustainable energy use for air conditioning is urgent. This paper focuses on the analysis of a vertical surface provided with a Parthenocissus quinquefolia (L.) Planch., a winter deciduous species, as green cover of a building, assessing the reduction of the solar radiation energy absorbed by the facade and, consequently, the heat flux (HF) transmitted into the internal ambient. This research shows that, in July, surface temperatures (STs) on the vegetated facade were up to 13 degrees C lower than on the unvegetated (bare) facade. Under the climate and environmental conditions of the green wall located at ENEA Casaccia Research Center, a saving of 2.22 and 1.94 kWh(e)/m(2) , respectively in 2019 and 2020, for the summer cooling electricity load, was achieved. These energy reductions also allowed the saving of 985 and 862 g CO2/m(2) emissions, respectively, in 2019 and 2020. Ultimately, a green factor named K-v* was also elaborated to evaluate the influence of vegetation on the STs as well as on HFs transmitted into the indoor ambient and adapted to the case of a detached vertical green cover. Measurements of K-v* factor lasting three years showed the suitability of this index for defining the shading capacity of the vegetation on the building facade surfaces, which can be used to predict thermal gains and effects in a building endowed of a vertical green system

Green roofs and green façades for improving sustainability of towns

Nowadays, buildings in Europe account for a consumption of 40% of total energy use and about 65% of total electricity consumption. According to the European Directive on the energy performance of buildings (EPBD Directive), solutions such as green roofs and green walls can help to reduce energy consumptions and the greenhouse gases emissions by buildings. The installation of plant systems covering some surfaces of the building allows to reach an improvement of the building's energy efficiency mainly by reducing the energy demand for cooling in warm periods. The green layers used for buildings contribute to improve thermal insulation, since they reduce the direct solar radiation while the evaporative cooling contributes to create a better local microclimate. This paper provides the first data collected by a green wall prototype in progress at ENEA Casaccia Centre to investigate the effects of this natural green solution on the energy efficiency of buildings. The project was funded by the Programme Research of Electrical System, and is being carried out in cooperation with the Universities of Pisa, Bari and Viterbo

Integrated Genomic, Functional, and Prognostic Characterization of Atypical Chronic Myeloid Leukemia

Atypical chronic myeloid leukemia (aCML) is a BCR-ABL1-negative clonal disorder, which belongs to the myelodysplastic/myeloproliferative group. This disease is characterized by recurrent somatic mutations in SETBP1, ASXL1 and ETNK1 genes, as well as high genetic heterogeneity, thus posing a great therapeutic challenge. To provide a comprehensive genomic characterization of aCML we applied a high-throughput sequencing strategy to 43 aCML samples, including both whole-exome and RNA-sequencing data. Our dataset identifies ASXL1, SETBP1, and ETNK1 as the most frequently mutated genes with a total of 43.2%, 29.7 and 16.2%, respectively. We characterized the clonal architecture of 7 aCML patients by means of colony assays and targeted resequencing. The results indicate that ETNK1 variants occur early in the clonal evolution history of aCML, while SETBP1 mutations often represent a late event. The presence of actionable mutations conferred both ex vivo and in vivo sensitivity to specific inhibitors with evidence of strong in vitro synergism in case of multiple targeting. In one patient, a clinical response was obtained. Stratification based on RNA-sequencing identified two different populations in terms of overall survival, and differential gene expression analysis identified 38 significantly overexpressed genes in the worse outcome group. Three genes correctly classified patients for overall survival

Pain and Frailty in Hospitalized Older Adults

Introduction: Pain and frailty are prevalent conditions in the older population. Many chronic diseases are likely involved in their origin, and both have a negative impact on quality of life. However, few studies have analysed their association. Methods: In light of this knowledge gap, 3577 acutely hospitalized patients 65 years or older enrolled in the REPOSI register, an Italian network of internal medicine and geriatric hospital wards, were assessed to calculate the frailty index (FI). The impact of pain and some of its characteristics on the degree of frailty was evaluated using an ordinal logistic regression model after adjusting for age and gender. Results: The prevalence of pain was 24.7%, and among patients with pain, 42.9% was regarded as chronic pain. Chronic pain was associated with severe frailty (OR = 1.69, 95% CI 1.38–2.07). Somatic pain (OR = 1.59, 95% CI 1.23–2.07) and widespread pain (OR = 1.60, 95% CI 0.93–2.78) were associated with frailty. Osteoarthritis was the most common cause of chronic pain, diagnosed in 157 patients (33.5%). Polymyalgia, rheumatoid arthritis and other musculoskeletal diseases causing chronic pain were associated with a lower degree of frailty than osteoarthritis (OR = 0.49, 95%CI 0.28–0.85). Conclusions: Chronic and somatic pain negatively affect the degree of frailty. The duration and type of pain, as well as the underlying diseases associated with chronic pain, should be evaluated to improve the hospital management of frail older people

The multifaceted spectrum of liver cirrhosis in older hospitalised patients: Analysis of the REPOSI registry

Background: Knowledge on the main clinical and prognostic characteristics of older multimorbid subjects with liver cirrhosis (LC) admitted to acute medical wards is scarce. Objectives: To estimate the prevalence of LC among older patients admitted to acute medical wards and to assess the main clinical characteristics of LC along with its association with major clinical outcomes and to explore the possibility that well-distinguished phenotypic profiles of LC have classificatory and prognostic properties. Methods: A cohort of 6,193 older subjects hospitalised between 2010 and 2018 and included in the REPOSI registry was analysed. Results: LC was diagnosed in 315 patients (5%). LC was associated with rehospitalisation (age-sex adjusted hazard ratio, [aHR] 1.44; 95% CI, 1.10-1.88) and with mortality after discharge, independently of all confounders (multiple aHR, 2.1; 95% CI, 1.37-3.22), but not with in-hospital mortality and incident disability. Three main clinical phenotypes of LC patients were recognised: relatively fit subjects (FIT, N = 150), subjects characterised by poor social support (PSS, N = 89) and, finally, subjects with disability and multimorbidity (D&M, N = 76). PSS subjects had an increased incident disability (35% vs 13%, P < 0.05) compared to FIT. D&M patients had a higher mortality (in-hospital: 12% vs 3%/1%, P < 0.01; post-discharge: 41% vs 12%/15%, P < 0.01) and less rehospitalisation (10% vs 32%/34%, P < 0.01) compared to PSS and FIT. Conclusions: LC has a relatively low prevalence in older hospitalised subjects but, when present, accounts for worse post-discharge outcomes. Phenotypic analysis unravelled the heterogeneity of LC older population and the association of selected phenotypes with different clinical and prognostic features

Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population

Tirosine kinase inhibitors adverse events

The authors discuss dasatinib as a tyrosine kinase inhibitor with cardiovascular toxicity, which Lenihan and Kowey did not include in their article “Overview and Management of Cardiac Adverse Events Associated With Tyrosine Kinase Inhibitors.