7,349 research outputs found
Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens, and toxins from the gut lumen into the circulation. The equilibrium between the rate of apoptosis and shedding of senescent epithelial cells at the villus tip, and the generation of new cells in the crypt, is key to maintaining tissue homeostasis. However, in both localized and systemic inflammation, this balance may be disturbed as a result of pathological IEC shedding. Shedding of IECs from the epithelial monolayer may cause transient gaps or microerosions in the epithelial barrier, resulting in increased intestinal permeability. Although pathological IEC shedding has been observed in mouse models of inflammation and human intestinal conditions such as inflammatory bowel disease, understanding of the underlying mechanisms remains limited. This process may also be an important contributor to systemic and intestinal inflammatory diseases and gut barrier dysfunction in domestic animal species. This review aims to summarize current knowledge about intestinal epithelial cell shedding, its significance in gut barrier dysfunction and host-microbial interactions, and where research in this field is directed
Sustainable Urban Transformation and the Green Urban Economy
This chapter explores the connections between the concepts of sustainable urban transformation and the green urban economy, proposes a framework for understanding how these concepts “fit” together, and makes some practical suggestions for local governments (and national and international policy)
Engaging Undergraduates in Science Research: Not Just About Faculty Willingness.
Despite the many benefits of involving undergraduates in research and the growing number of undergraduate research programs, few scholars have investigated the factors that affect faculty members' decisions to involve undergraduates in their research projects. We investigated the individual factors and institutional contexts that predict faculty members' likelihood of engaging undergraduates in their research project(s). Using data from the Higher Education Research Institute's 2007-2008 Faculty Survey, we employ hierarchical generalized linear modeling to analyze data from 4,832 science, technology, engineering, and mathematics (STEM) faculty across 194 institutions to examine how organizational citizenship behavior theory and social exchange theory relate to mentoring students in research. Key findings show that faculty who work in the life sciences and those who receive government funding for their research are more likely to involve undergraduates in their research project(s). In addition, faculty at liberal arts or historically Black colleges are significantly more likely to involve undergraduate students in research. Implications for advancing undergraduate research opportunities are discussed
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Pressure-induced suppression of ferromagnetism in the itinerant ferromagnet LaCrSb3
We have performed an extensive pressure-dependent structural, spectroscopic, and electrical transport study of LaCrSb3. The ferromagnetic phase (TC=120 K at p = 0 GPa) is fully suppressed by p = 26.5 GPa and the Cr moment decreases steadily with increasing pressure. The unit-cell volume decreases smoothly up to p = 55 GPa. We find that the bulk modulus and suppression of the magnetism are in good agreement with theoretical predictions, but the Cr moment decreases smoothly with pressure, in contrast to steplike drops predicted by theory. The ferromagnetic ordering temperature appears to be driven by the Cr moment
Visual representation of National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network criteria for anaphylaxis
We present a user-friendly visual representation of The National Institute of Allergy and Infectious Disease and the Food Allergy and Anaphylaxis Network criteria so as to enhance recognition of anaphylaxis and active teaching and learning
Interfacial Tensions near Critical Endpoints: Experimental Checks of EdGF Theory
Predictions of the extended de Gennes-Fisher local-functional theory for the
universal scaling functions of interfacial tensions near critical endpoints are
compared with experimental data. Various observations of the binary mixture
isobutyric acid water are correlated to facilitate an analysis of the
experiments of Nagarajan, Webb and Widom who observed the vapor-liquid
interfacial tension as a function of {\it both} temperature and density.
Antonow's rule is confirmed and, with the aid of previously studied {\it
universal amplitude ratios}, the crucial analytic ``background'' contribution
to the surface tension near the endpoint is estimated. The residual singular
behavior thus uncovered is consistent with the theoretical scaling predictions
and confirms the expected lack of symmetry in . A searching test of
theory, however, demands more precise and extensive experiments; furthermore,
the analysis highlights, a previously noted but surprising, three-fold
discrepancy in the magnitude of the surface tension of isobutyric acid
water relative to other systems.Comment: 6 figure
‘The phoenix that always rises from the ashes’: an exploratory qualitative study of the experiences of an initiative informed by principles of psychological first aid following the Beirut blast
BACKGROUND: On 4 August 2020, an explosion occurred in Beirut, Lebanon. Hundreds of people were killed, thousands injured and displaced. An initiative was rapidly initiated to provide remote support informed by psychological first aid for the mental health of Lebanese young adults affected by the blast. However, little is known about recipients’ experiences of such initiatives. OBJECTIVES: This study aimed to qualitatively explore the experiences of supporters and recipients in the community-led initiative following the blast. METHOD: We recruited a diverse sample of four supporters and four Lebanese recipients who took part in the Beirut initiative. Semi-structured interviews were conducted with participants. Reflexive thematic analysis was used to analyse the qualitative data. RESULTS: We developed five themes from the qualitative interviews, which highlighted ideas around accessibility, alienation, the relationship, elements of the safe space created by the initiative, and unmet needs and areas for improvement. Recipients described the detrimental impact of the blast on their mental health within the Lebanese context and beyond. Recipients and supporters elucidated complex experiences of the support and its impact. CONCLUSIONS: Our findings suggest remote support has the potential to be acceptable for young adults in Lebanon. Further research into support informed by psychological first aid after similar crisis events is warranted
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