Alien Registration- Campbell, Agnes (Falmouth, Cumberland County)

https://digitalmaine.com/alien_docs/23595/thumbnail.jp

Photograph of Agnes Campbell, Hobart, Tasmania

Photograph of Agnes Campbell. The photographer was Henry Hall Baily who had studios in Elizabeth and Liverpool Streets, Hobart from 1865 until 1918

Gambian women, violence and its intersection with HIV/AIDS: agency through feminist participatory research

Research has identified a strong correlation between HIV/AIDS and gender-based violence, yet few studies centre the experiential knowledge of HIV sero-positive women and practitioners. This thesis, based on fieldwork conducted in the Gambia, is grounded in data on HIV positive women’s experiences of violence and practices of resistance, revealing context specific complexities and challenges. Data collection methods included diaries, focus groups and in-depth individual interviews with a participant group of sixty sero-positive women in six Gambian HIV Support Societies, and twenty field practitioners working in the areas of violence and HIV/AIDS. I argue in this thesis that there are intersecting underlying factors (patriarchy, gerontocracy and structural violence) that contribute to women’s experiences of violence and abuse that render them vulnerable to HIV. In addition, that alongside the more visible gendered violences which intersect with HIV/AIDS. Accounts of women living with HIV revealed that stigma is discreditable and discredited attributes. It contends that stigma should be seen as an ‘everyday’ practice of normalised violence, which has very harmful emotional, psychological, economic and physical effects. The research also suggests that violence against women in the context of HIV is not limited solely to male perpetrators. In the Gambia there has been limited success in the translation of women’s rights agendas into concrete and effective interventions, partly due to a lack of attention to socio-cultural context and the lived experiences of HIV positive women. The thesis concludes that culturally specific, integrated health and social justice approaches are necessary, which are grounded in women’s everyday practices of agency and resistance, and which in particular address the fear of dethronement (loss of power, privileges and prestige) amongst men and older members of society

Addressing the mental health needs of children affected by HIV in Rwanda: validation of a rapid depression screening tool for children 7–14 years old

Background: Depression in children presents a significant health burden to society and often co-exists with chronic illnesses, such as human immunodeficiency virus (HIV). Research has demonstrated that 10–37% of children and adolescents living with HIV also suffer from depression. Low-and-middle income countries (LMICs) shoulder a disproportionate burden of HIV among other health challenges, but reliable estimates of co-morbid depression are lacking in these settings. Prior studies in Rwanda, a LMIC of 12 million people in East Africa, found that 25% of children living with HIV met criteria for depression. Though depression may negatively affect adherence to HIV treatment among children and adolescents, most LMICs fail to routinely screen children for mental health problems due to a shortage of trained health care providers. While some screening tools exist, they can be costly to implement in resource-constrained settings and are often lacking a contextual appropriateness. Methods: Relying on international guidelines for diagnosing depression, Rwandan health experts developed a freely available, open-access Child Depression Screening Tool (CDST). To validate this tool in Rwanda, a sample of 296 children with a known diagnosis of HIV between ages 7–14 years were recruited as study participants. In addition to completing the CDST, all participants were evaluated by a mental health professional using a structured clinical interview. The validity of the CDST was assessed in terms of sensitivity, specificity, and a receiver operating characteristic (ROC) curve. Results: This analysis found that depression continues to be a co-morbid condition among children living with HIV in Rwanda. For identifying these at-risk children, the CDST had a sensitivity of 88.1% and specificity of 96.5% in identifying risk for depression among children living with HIV at a cutoff score of 6 points. This corresponded with an area under the ROC curve of 92.3%. Conclusions: This study provides evidence that the CDST is a valid tool for screening depression among children affected by HIV in a resource-constrained setting. As an open-access and freely available tool in LMICs, the CDST can allow any health practitioner to identify children at risk of depression and refer them in a timely manner to more specialized mental health services. Future work can show if and how this tool has the potential to be useful in screening depression in children suffering from other chronic illnesses

Prevalence of Dating Partner Violence and Suicidal Ideation Among Male and Female University Students Worldwide

This paper presents findings from the International Dating Violence study regarding the prevalence of physical assault, sexual coercion, and suicidal ideation among university students and explores the relationships between suicidal ideation and dating violence. Nearly 16,000 university students from 22 sites in 21 countries were recruited through convenience sampling. The results showed that although there were large differences between countries, the lowest rates of dating violence were still quite high. Male and female students were remarkably similar in the proportion of those who physically assaulted a partner or reported being a victim of sexual coercion. Correlation analysis revealed that perpetrators and victims of physical assault had an increased rate of suicidal ideation. Depression accounted for the relationship between dating violence and suicidal ideation. This study highlights a need for the development of universal screening and targeted services for violence, depression, and suicide prevention. © 2008 American College of Nurse-Midwives.postprin

Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer

Tyrosine kinase (TK) fusions are attractive drug targets in cancers. However, rapid identification of these lesions has been hampered by experimental limitations. Our in silico analysis of known cancer-derived TK fusions revealed that most breakpoints occur within a defined region upstream of a conserved GXGXXG kinase motif. We therefore designed a novel DNA-based targeted sequencing approach to screen systematically for fusions within the 90 human TKs; it should detect 92% of known TK fusions. We deliberately paired ‘in-solution’ DNA capture with 454 sequencing to minimize starting material requirements, take advantage of long sequence reads, and facilitate mapping of fusions. To validate this platform, we analyzed genomic DNA from thyroid cancer cells (TPC-1) and leukemia cells (KG-1) with fusions known only at the mRNA level. We readily identified for the first time the genomic fusion sequences of CCDC6-RET in TPC-1 cells and FGFR1OP2-FGFR1 in KG-1 cells. These data demonstrate the feasibility of this approach to identify TK fusions across multiple human cancers in a high-throughput, unbiased manner. This method is distinct from other similar efforts, because it focuses specifically on targets with therapeutic potential, uses only 1.5 µg of DNA, and circumvents the need for complex computational sequence analysis

Natational Dress: Functionality, Fashion and the Fracturing of Separate Spheres in Victorian Britain

In 1873, The Englishwoman's Domestic Magazine extolled the values of swimming for women and gave advice on the best form of bathing dress, one which preserved modesty and met the demands of contemporary fashion. This essentially impractical type of bathing outfit has been the subject of much of the historiography surrounding female swimming costumes but it was not the only swimming dress on show during the “long” Victorian period. The women of all classes who participated in more serious swimming required something functional rather than fashionable while working-class professional natationists, who appeared regularly in water shows throughout the country, wore attire that combined functionality, tight to the body while allowing freedom of movement, with public appeal, a critical consideration for female exhibitors. Their activities and costumes challenged prevailing notions of “separate spheres” and this paper explores Victorian aquatic dress in the context of class, gender and social space

ShORRT (Short, all-Oral Regimens for Rifampicin-resistant Tuberculosis) Research Package

TDR in close collaboration with the Global TB Programme at WHO and technical partners the WHO Global TB Programme is leading the development of ShORRT (Short, all-Oral Regimens For Rifampicin-resistant Tuberculosis), an operational research package to assess the effectiveness, safety, feasibility, acceptability, cost and impact (including on health-related quality of life) of the use of all-oral shorter drug regimens for adults and children with MDR/RR-TB