Physics potential of the CERN-MEMPHYS neutrino oscillation project

We consider the physics potential of CERN based neutrino oscillation experiments consisting of a Beta Beam (BB) and a Super Beam (SPL) sending neutrinos to MEMPHYS, a 440 kt water \v{C}erenkov detector at Frejus, at a distance of 130 km from CERN. The $\theta_{13}$ discovery reach and the sensitivity to CP violation are investigated, including a detailed discussion of parameter degeneracies and systematical errors. For SPL sensitivities similar to the ones of the phase II of the T2K experiment (T2HK) are obtained, whereas the BB may reach significantly better sensitivities, depending on the achieved number of total ion decays. The results for the CERN-MEMPHYS experiments are less affected by systematical uncertainties than T2HK. We point out that by a combination of data from BB and SPL a measurement with antineutrinos is not necessary and hence the same physics results can be obtained within about half of the measurement time compared to one single experiment. Furthermore, it is shown how including data from atmospheric neutrinos in the MEMPHYS detector allows to resolve parameter degeneracies and, in particular, provides sensitivity to the neutrino mass hierarchy and the octant of $\theta_{23}$.Comment: 32 pages, 17 figures, minor improvements on the text wrt to v2, version to appear in JHE

PARISROC, a Photomultiplier Array Integrated Read Out Chip

PARISROC is a complete read out chip, in AMS SiGe 0.35 !m technology, for photomultipliers array. It allows triggerless acquisition for next generation neutrino experiments and it belongs to an R&D program funded by the French national agency for research (ANR) called PMm2: ?Innovative electronics for photodetectors array used in High Energy Physics and Astroparticles? (ref.ANR-06-BLAN-0186). The ASIC (Application Specific Integrated Circuit) integrates 16 independent and auto triggered channels with variable gain and provides charge and time measurement by a Wilkinson ADC (Analog to Digital Converter) and a 24-bit Counter. The charge measurement should be performed from 1 up to 300 photo- electrons (p.e.) with a good linearity. The time measurement allowed to a coarse time with a 24-bit counter at 10 MHz and a fine time on a 100ns ramp to achieve a resolution of 1 ns. The ASIC sends out only the relevant data through network cables to the central data storage. This paper describes the front-end electronics ASIC called PARISROC.Comment: IEEE Nuclear Science Symposium an Medical Imaging Conference (2009 NSS/MIC

MEMPHYS:A large scale water Cerenkov detector at Fr\'ejus

A water \v{C}erenkov detector project, of megaton scale, to be installed in the Fr\'ejus underground site and dedicated to nucleon decay, neutrinos from supernovae, solar and atmospheric neutrinos, as well as neutrinos from a super-beam and/or a beta-beam coming from CERN, is presented and compared with competitor projects in Japan and in the USA. The performances of the European project are discussed, including the possibility to measure the mixing angle $\theta_{13}$ and the CP-violating phase $\delta$.Comment: 1+33 pages, 14 figures, Expression of Interest of MEMPHYS projec

Acyl-Imidazoles A Privileged Ester Surrogate for Enantioselective Synthesis

International audienceSince the first report by Evans in asymmetric Friedel‐Crafts reactions, the use of acyl‐imidazoles has blossomed as powerful ester/amide surrogates. The imidazole scaffold indeed displays stability and special activation features allowing both better reactivity and selectivity in traditional ester/amide functionalizations: α‐(enolate chemistry), β‐(conjugate additions), α,β‐(cycloadditions) or γ/δ‐(vinylogous). An overview of the contemporary and growing interest in acyl‐imidazoles in metal‐ and organo‐catalyzed transformations (bio‐hybrid catalytic systems will be fully described in a back‐to‐back Minireview) will be highlighted. Moreover, post‐functionalization expediencies are also going to be discussed in this Minireview

BAORadio : Cartographie 3D de la distribution de gaz HI_I dans l'Univers

3D mapping of matter distribution in the universe through the 21 cm radio emission of atomic hydrogen is a complementary approach to optical surveys for the study of the Large Scale Structures, in particular for measuring the BAO (Baryon Acoustic Oscillation) scale up to redshifts z <~ 3 and constrain dark energy. We propose to carry such a survey through a novel method, called intensity mapping, without detecting individual galaxies radio emission. This method requires a wide band instrument, 100 MHz or larger, and multiple beams, while a rather modest angular resolution of 10 arcmin would be sufficient. The instrument would have a few thousand square meters of collecting area and few hundreds of simultaneous beams. These constraints could be fulfilled with a dense array of receivers in interferometric mode, or a phased array at the focal plane of a large antenna

DNA-Based Asymmetric Inverse Electron-Demand Hetero-Diels-Alder

International audienceWhile artificial cyclases hold great promise in chemical synthesis, this work presents the first example of a DNA-catalyzed inverse electron-demand hetero-Diels-Alder (IEDHDA) between dihydrofuran and various α,β-unsaturated acyl imidazoles. The resulting fused bicyclic O,O-acetals containing three contiguous stereogenic centers are obtained in high yields (up to 99 %) and excellent diastereo- (up to >99:1 dr) and enantioselectivities (up to 95 % ee) using a low catalyst loading. Most importantly, these results show that the concept of DNA-based asymmetric catalysis can be expanded to new synthetic transformations offering an efficient, sustainable, and highly selective tool for the construction of chiral building blocks

GPCR-OKB: the G protein coupled receptor oligomer knowledge base

Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers