34 research outputs found

    Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness

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    In response to the COVID-19 pandemic, many governments have taken drastic measures to avoid an overflow of intensive care units. Accurate metrics of disease spread are critical for the reopening strategies. Here, we show that self-reports of smell/taste changes are more closely associated with hospital overload and are earlier markers of the spread of infection of SARS-CoV-2 than current governmental indicators. We also report a decrease in self-reports of new onset smell/taste changes as early as 5 days after lockdown enforcement. Cross-country comparisons demonstrate that countries that adopted the most stringent lockdown measures had faster declines in new reports of smell/taste changes following lockdown than a country that adopted less stringent lockdown measures. We propose that an increase in the incidence of sudden smell and taste change in the general population may be used as an indicator of COVID-19 spread in the population

    Contribution de l’anthropologie sensorielle à l’étude du COVID-19

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    En réponse à la pandémie COVID-19, de nombreux gouvernements ont pris des mesures sans précédent pour éviter un engorgement des unités de réanimation. En raison du lourd impact sociétal et économique de ces initiatives, des indicateurs épidémiologiques précis de la propagation de la maladie sont essentiels aux autorités de santé publique. Dans le même temps, la perturbation des perceptions des odeurs et du goût ont été identifiés comme l’un des symptômes les plus spécifiques de la maladie COV..

    Santé mentale et population universitaire : un laboratoire-vivant au service de la communauté : rapport de recherche

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    Cette étude a trois objectifs : 1) Identifier les principaux enjeux de santé des étudiant·es et des employé·es de l’UQAC en contexte pandémique, 2) Répertorier l’ensemble des mesures de soutien à la santé mises à la disposition des étudiant·es et des employé·es de l’UQAC, et 3) Identifier de nouvelles solutions à mettre en place afin de pallier les manques et de soutenir les étudiant·es et les employé·es de l’UQAC

    The gut microbial metabolite formate exacerbates colorectal cancer progression

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    The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, the crosstalk between the gut microbiome and the host in relation to tumour cell metabolism remains largely unexplored. Here we show that formate, a metabolite produced by the CRC-associated bacterium Fusobacterium nucleatum, promotes CRC development. We describe molecular signatures linking CRC phenotypes with Fusobacterium abundance. Cocultures of F. nucleatum with patient-derived CRC cells display protumorigenic effects, along with a metabolic shift towards increased formate secretion and cancer glutamine metabolism. We further show that microbiome-derived formate drives CRC tumour invasion by triggering AhR signalling, while increasing cancer stemness. Finally, F. nucleatum or formate treatment in mice leads to increased tumour incidence or size, and Th17 cell expansion, which can favour proinflammatory profiles. Moving beyond observational studies, we identify formate as a gut-derived oncometabolite that is relevant for CRC progression

    Les troubles du comportement chez le chien et leurs traitements

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    AIX-MARSEILLE2-BU Pharmacie (130552105) / SudocSudocFranceF
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