Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination

Objectives: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy. Methods: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The reference was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used. Results: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P <0.0001) and that of anti-hepatitis D virus (HDV) remained stable (9.3% vs 8.3%). In both cohorts, about 25% of the patients had cirrhosis, and those in the PITER cohort were older. HBeAg-positive was 5.0% vs 12.6% (P <0.0001) and anti-HDV positive 24.8% vs 17.5% (P <0.0017). In the logistic model, the variables associated with cirrhosis were anti-HDV-positive (odds ratio = 10.08; confidence interval 7.63-13.43), age, sex, and body mass index; the likelihood of cirrhosis was reduced by 40% in the PITER cohort. Among non-Italians, 12.3% were HBeAg-positive (vs 23.4% in the MASTER cohort; P <0.0001), and 12.3% were anti-HDV-positive (vs 11.1%). Overall, the adherence to the European Association for the Study of the Liver recommendations for antiviral treatment increased over time. Conclusion: Chronic hepatitis B virus infection appears to be in the process of becoming under control in Italy; however, HDV infection is still a health concern in patients with cirrhosis and in migrants

CUBES: a UV spectrograph for the future

In spite of the advent of extremely large telescopes in the UV/optical/NIR range, the current generation of 8-10m facilities is likely to remain competitive at ground-UV wavelengths for the foreseeable future. The Cassegrain U-Band Efficient Spectrograph (CUBES) has been designed to provide high-efficiency (>40%) observations in the near UV (305-400 nm requirement, 300-420 nm goal) at a spectral resolving power of R>20,000, although a lower-resolution, sky-limited mode of R ~ 7,000 is also planned. CUBES will offer new possibilities in many fields of astrophysics, providing access to key lines of stellar spectra: a tremendous diversity of iron-peak and heavy elements, lighter elements (in particular Beryllium) and light-element molecules (CO, CN, OH), as well as Balmer lines and the Balmer jump (particularly important for young stellar objects). The UV range is also critical in extragalactic studies: the circumgalactic medium of distant galaxies, the contribution of different types of sources to the cosmic UV background, the measurement of H2 and primordial Deuterium in a regime of relatively transparent intergalactic medium, and follow-up of explosive transients. The CUBES project completed a Phase A conceptual design in June 2021 and has now entered the Phase B dedicated to detailed design and construction. First science operations are planned for 2028. In this paper, we briefly describe the CUBES project development and goals, the main science cases, the instrument design and the project organization and management

Dust Environment Model of the Interstellar Comet 2I/Borisov

2I/Borisov is the first interstellar comet discovered on 2019 August 30, and it soon showed a coma and a dust tail. This study reports the results of images obtained at the Telescopio Nazionale Galileo telescope, on La Palma - Canary Islands, in 2019 November and December. The images have been obtained with the R filter in order to apply our dust tail model. The model has been applied to the comet 67P/Churyumov-Gerasimenko and compared to the Rosetta dust measurements showing a very good agreement. It has been applied to the comet 2I/Borisov, using almost the same parameters, obtaining a dust environment similar to that of 67P/Churyumov-Gerasimenko, suggesting that the activity may be very similar. The dust tail analysis provided a dust-loss rate Qd ≍ 35 kg s-1 in 2019 November and Qd ≍ 30 kg s-1 in 2019 December

CUBES : the Cassegrain U-band Efficient Spectrograph

In the era of Extremely Large Telescopes, the current generation of 8-10m facilities are likely to remain competitive at ground-UV wavelengths for the foreseeable future. The Cassegrain U-Band Efficient Spectrograph (CUBES) has been designed to provide high-efficiency (> 40%) observations in the near UV (305-400 nm requirement, 300-420 nm goal) at a spectral resolving power of R >20, 000 (with a lower-resolution, sky-limited mode of R ~7, 000). With the design focusing on maximizing the instrument throughput (ensuring a Signal to Noise Ratio (SNR) ~20 per high-resolution element at 313 nm for U ~18.5 mag objects in 1h of observations), it will offer new possibilities in many fields of astrophysics, providing access to key lines of stellar spectra: a tremendous diversity of iron-peak and heavy elements, lighter elements (in particular Beryllium) and light-element molecules (CO, CN, OH), as well as Balmer lines and the Balmer jump (particularly important for young stellar objects). The UV range is also critical in extragalactic studies: the circumgalactic medium of distant galaxies, the contribution of different types of sources to the cosmic UV background, the measurement of H2 and primordial Deuterium in a regime of relatively transparent intergalactic medium, and follow-up of explosive transients. The CUBES project completed a Phase A conceptual design in June 2021 and has now entered the detailed design and construction phase. First science operations are planned for 2028

CO

C/2017 K2 (Pan-STARRS) is an Oort cloud comet discovered in May 2017. Ground observations have revealed that this long-period comet was active at heliocentric distance of 35 au. At such a distance, activity cannot be driven by the sublimation or the exothermic crystallization of water ice. We assume that the activity of comet C/2017 K2 may be driven by the sublimation of super-volatile ices such as CO and CO2. The nature of parent molecules driving the unprecedented activity of comet C/2017 K2 can be investigated by analyzing its spectrum. In particular, the analysis of atomic oxygen emission lines and the calculation of the green (5577.339 Å) to red (6300.304 and 6363.776 Å) line intensity ratio (hereafter G/R) can reveal the nature of molecules driving cometary activity. We report on the detection of atomic oxygen lines in the spectra of comet C/2017 K2 (Pan-STARRS) from high-resolution spectra obtained at the Telescopio Nazionale Galileo (TNG) on 24 June and 2 July 2022 using the High Accuracy Radial velocity Planet Searcher North (HARPS-N) echelle spectrograph. We found G/R ratios equal to 0.29±0.02 (24 July 2022) and 0.27±0.01 (2 July 2022), which are consistent with a cometary activity driven by CO2, even if located at 2.8 au from the Sun. To better define the nature of the driving molecule, we measured the width of the three oxygen lines and found that the green line in the spectrum of 24 July 2022 is wider than either of the two red lines. This allows us to argue that CO2 is dissociated by highly energetic solar photons that produce O(1S) with a large excess velocity

A high-spectral-resolution catalog of emission lines in the visible spectrum of comet C/2020 F3 (NEOWISE)

Aims. Comet C/2020 F3 (NEOWISE) is considered to be the brightest comet observed in the northern hemisphere since the passage of comet C/1995 O1 (Hale-Bopp) in 1997. Since the study of comets offers a unique opportunity to investigate the early stages of the formation and evolution of our Sun and the Solar System, we obtained high-resolution optical spectra (R = λ/Δλ = 11 5000) of comet NEOWISE. The unique passage and its brightness yielded spectra with a large number of emission lines, providing information on the coma composition and the physical and chemical processes occurring in the nucleus. The spectra have been used to generate a catalog of emission lines to be used for future studies of comets since there are no catalogs in the literature with such a high spectral resolution. Methods. Two high-resolution spectra of comet NEOWISE were obtained, on 26 July 2020 (geocentric distance of 0.7 AU) and 5 August 2020 (geocentric distance of 0.89 AU), with the High Accuracy Radial velocity Planet Searcher for the Northern hemisphere (HARPS-N) echelle spectrograph installed on the 360 cm Telescopio Nazionale Galileo. The spectra cover the range between 383 and 693 nm, and have been extracted using the HARPS-N Data Reduction Pipeline. To analyze the spectra and compile the high-resolution catalog, we collected several laboratory molecular line lists that cover the same wavelength range as that of our spectra. To validate the final identification, we compared our catalog with other atlases that resulted from the spectral analysis of other comets. Results. We generate a high-spectral-resolution catalog of emission lines observed in comet NEOWISE, providing the identification for 4488 lines. We found cometary lines due to CN, CH, C2, C3, and NH2 and atomic lines due to NaI and [OI]

Topographic correction of HiRISE and CaSSIS images: Validation and application to color observations of Martian albedo features

The topographic correction of satellite images has to be applied to both disentangle albedo features from illumination effects induced by local topography and performspectrophotometric analyses of planetary surfaces. This work focuses on the modeling and removal of surface brightness variations induced by topography, referred astopographic shading, from high resolution images of Mars. Topographic shading can be modeled through functions of the surface illumination and observation anglescalled disk functions. We consider four disk functions that are widely used in planetary photometry: the Lambert, Lommel-Seeliger, Akimov and Minnaert diskfunctions. We test and evaluate their performances in removing topographic shading from High Resolution Imaging Science Experiment (HiRISE) and Colour andSurface Science Imaging System (CaSSIS) images. We here validate our method, moreover, we report scientific applications to single or multi-band datasets byanalyzing topographically corrected HiRISE colour observations of Martian recurring slope lineae and dust devil tracks, as well as CaSSIS panchromatic observations