The two-mode puzzle: Confronting self-interacting neutrinos with the full shape of the galaxy power spectrum

A cosmological scenario in which the onset of neutrino free-streaming in the early universe is delayed until close to the epoch of matter-radiation equality has been shown to provide a good fit to some cosmic microwave background (CMB) data, while being somewhat disfavored by Planck CMB polarization data. To clarify this situation, we investigate in this paper CMB-independent constraints on this scenario from the Full Shape of the galaxy power spectrum. Although this scenario predicts significant changes to the linear matter power spectrum, we find that it can provide a good fit to the the galaxy power spectrum data. Interestingly, we show that the data display a modest preference for a delayed onset of neutrino free-streaming over the standard model of cosmology, which is driven by the galaxy power spectrum data on mildly non-linear scales. This conclusion is supported by both profile likelihood and Bayesian exploration analyses, showing robustness of the results. Compared to the standard cosmological paradigm, this scenario predicts a significant suppression of structure on subgalactic scales. While our analysis relies on the simplest cosmological representation of neutrino self-interactions, we argue that this persistent - and somehow consistent - picture in which neutrino free-streaming is delayed motivates the exploration of particle models capable of reconciling all CMB, large-scale structure, and laboratory data.Comment: 14 pages + references, 9 figures, 2 table

The human Schwann cell transcriptome: species-specificity, long-term stability and changes with differentiation

Cultured Schwann cells of human origin differ from those isolated from experimental animals in both phenotype and function. However, the basis for this divergence and its significance to potential clinical applications of the primary cells are not fully understood. In this study, we used RNA-seq to comprehensively analyze the human Schwann cell transcriptome and compare it to that of ratcells. We also studied the transcriptomics profiles of human Schwann cells subjected to: (1) the pro-mitogenic effect of growth factors in cells undergoing serial passaging in vitro, and (2) the pro-differentiating action of cAMP, a signal known to promote myelin gene expression in rodent cells.Despite the human Schwann cell transcriptome differedas much as 44% from that of rat Schwann cells established under identical conditions, the human cells maintained their expected Schwann cell identity regardless of sub-culture and the continued influence of mitogenic factors. Strikingly, the transcriptomes of low passage (proliferative) and late passage (senescent) human Schwann cells were essentially undistinguishable with the exception of roughly 100 differentially expressed genes in the senescentpopulations. On the contrary, the human Schwann cell transcriptome was readily and persistently shifted in response to a single treatment with cAMP analogs as highlighted by the >1,300 genes that were upregulated and the >1,700 genes that were downregulated within 1-day post-stimulation. In sum, these results confirmed that human Schwann cellsmaintain their typical gene expression profiles in culture unless challenged with a strong pro-differentiating stimulus. The observed stability of the human Schwann celltranscriptome in the face of expansion and mitogenic stimulation adds a level of safety for theuse of these glial cells in clinical transplantation.Fil: Monje, Paula. Indiana University; Estados Unidos. University of Miami; Estados UnidosFil: Sant, David. University of Miami; Estados UnidosFil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Camarena, Vladimir. University of Miami; Estados UnidosFil: Wang, Gaofeng. University of Miami; Estados UnidosXIV European Meeting on Glial cells in Health and DiseasePortoPortugalEuropean Meeting on Glial Cells in Health and Diseas

Gestión del tiempo para identificar las actividades críticas en la etapa de obra gruesa del Centro Comercial Real Plaza Este

El presente trabajo de investigación tiene como título “Gestión del tiempo para identificar las actividades críticas en la etapa de obra gruesa de Centro Comercial Real Plaza Este” cuyo objetivo principal fue identificar las actividades de mayor duración en la ejecución del proyecto. Los métodos y técnicas aplicadas en el presente estudio fueron cualitativa de tipo descriptiva. Se aplico como instrumento de recolección de datos otorgados por el Consorcio HV- DVC. La población de estudio estuvo definida por el sector 1B y 1C (FRENTE 01) de la etapa de obra gruesa del Centro Comercial Real Plaza Este. Con el método de la Línea de Balance se identificó las actividades que generaron retrasos ya que esta, asocia las actividades más incidentes las cuales fueron programadas en función al orden del proceso constructivo y a la disponibilidad de los recursos, tratando de eliminar actividades que generen retrasos, se realiza un análisis del cronograma de actividades iniciales, el método brinda una explicación sencilla pero primordial de cómo se va desarrollando la ejecución en cualquier etapa del proyecto. Los resultados obtenidos nos indicaron que se logró optimizar la duración de ejecución de las actividades del proyecto, Por medio de la representación gráfica de la recta y sus módulos. Se concluye que gracias a la aplicación del método la fecha final en la planificación del proyecto fue el 01 de julio del 2019 la cual estuvo dentro del plazo contractual, 29 días antes de la fecha límite de término del proyecto.Tesi

EEMD-MUSIC-Based Analysis for Natural Frequencies Identification of Structures Using Artificial and Natural Excitations

This paper presents a new EEMD-MUSIC- (ensemble empirical mode decomposition-multiple signal classification-) based methodology to identify modal frequencies in structures ranging from free and ambient vibration signals produced by artificial and natural excitations and also considering several factors as nonstationary effects, close modal frequencies, and noisy environments, which are common situations where several techniques reported in literature fail. The EEMD and MUSIC methods are used to decompose the vibration signal into a set of IMFs (intrinsic mode functions) and to identify the natural frequencies of a structure, respectively. The effectiveness of the proposed methodology has been validated and tested with synthetic signals and under real operating conditions. The experiments are focused on extracting the natural frequencies of a truss-type scaled structure and of a bridge used for both highway traffic and pedestrians. Results show the proposed methodology as a suitable solution for natural frequencies identification of structures from free and ambient vibration signals

L'esquí a Catalunya davant del canvi climàtic, de la incertesa a l'oportunitat

El sector turístic de neu dels Pirineus es caracteritza per ser un dels motors econòmics d'aquest territori. Alguns estudis analitzats indican que els Pirineus patiran un augment de la temperatura que influirà decisivament en la viabilitat de les estacions d'esquí, en pujar la cota de neu i disminuir la duració de la temporada. En el context de la resposta al canvi climàtic les estacions d'esquí i el sector turístic de neu poden considerar diferents mesures d'adaptació, atenent al seu grau de vulnerabilitat i les seves característiques geogràfiques pròpies. Amb sistemes de neu artificial hom preveu que bona part de les estacions podrien respondre fins el 2050, però només les estacions més altes seran viables a partir d'aquesta dècada i fins a final de segle, si be existiran grans diferencies depenent de la ubicació geogràfica. La variabilitat climàtica modificarà les destinacions triades pels turistes, amb conseqüències tant positives com negatives en la dinàmica dels fluxos turístics als Pirineus. Aquestes modificacions podrien ser una oportunitat per orientar els futurs canvis del model productiu de neu actual cap a un model productiu més estable i sostenible, amb un impacte ambiental menys intens però amb un caràcter molt més extensiu. La incertesa que genera l'impacte del canvi climàtic en les regions de muntanya podria donar pas a noves estratègies i oportunitats.El sector turístico de nieve de los Pirineos se caracteriza por ser uno de los motores económicos de este territorio. Algunos estudios analizados indican que los Pirineos sufrirán un aumento de la temperatura que influirá decisivamente en la viabilidad de las estaciones de esquí, al elevarse la cota de nieve y disminuir la duración de la temporada. En el contexto de la respuesta al cambio climático las estaciones de esquí y el sector turístico de nieve pueden considerar diferentes medidas de adaptación, atendiendo a su grado de vulnerabilidad y a sus características geográficas propias. Con sistemas de nieve artificial la mayor parte de las estaciones podrían responder hasta 2050, pero sólo las estaciones más altas serán viables a partir de esta década y hasta final de siglo, si bien existirán grandes diferencias dependiendo de la ubicación geográfica. La variabilidad climática modificará los destinos elegidos por los turistas, con consecuencias tanto positivas como negativas en la dinámica de los flujos turísticos en los Pirineos. Estas modificaciones podrían ser una oportunidad para orientar los futuros cambios del modelo productivo de nieve actual hacia un modelo productivo más estable y sostenible, con un impacto ambiental menos intenso pero con un carácter mucho más extensivo. La incertidumbre que genera el impacto del cambio climático en las regiones de montaña podría dar paso a nuevas estrategias y oportunidades.The snow tourism sector in the Pyrenees is characterized by being one of the economic engines of this territory. Some studies analyzed indicate that the Pyrenees will suffer a rise in temperature increasing temperatures in the medium and long term will have a decisive influence on the viability of ski resorts, by raising the snow level and decreasing the duration of the season. In the context of the response to climate change, ski resorts and the snow tourism sector may consider different adaptation measures, depending on their degree of vulnerability and their own geographical characteristics. With artificial snow systems, most resorts will be able to respond, but only the highest resorts will be viable from this decade until the end of the century, although there will be large differences depending on geographic location. Climate variability will change the destinations chosen by tourists, causing both positive and negative repercussions on the dynamics of tourist flows in the Pyrenees. These modifications could be an opportunity to guide future changes in the current snow production model towards a more stable and sustainable production model with a less intense environmental impact but with a much more extensive character. The uncertainty change on mountain regions could lead to new strategies and opportunities

Magnetic separation of peripheral nerve-resident cells underscores key molecular features of human Schwann cells and fibroblasts: an immunochemical and transcriptomics approach

Nerve-derived human Schwann cell (SC) cultures are irreplaceable models for basic and translational research but their use can be limited due to the risk of fibroblast overgrowth. Fibroblasts are an ill-defined population consisting of highly proliferative cells that, contrary to human SCs, do not undergo senescence in culture. We initiated this study by performing an exhaustive immunological and functional characterization of adult nerve-derived human SCs and fibroblasts to reveal their properties and optimize a protocol of magnetic-activated cell sorting (MACS) to separate them effectively both as viable and biologically competent cells. We next used immunofluorescence microscopy imaging, flow cytometry analysis and next generation RNA sequencing (RNA-seq) to unambiguously characterize the post-MACS cell products. High resolution transcriptome profiling revealed the identity of key lineage-specific transcripts and the clearly distinct neural crest and mesenchymal origin of human SCs and fibroblasts, respectively. Our analysis underscored a progenitor- or stem cell-like molecular phenotype in SCs and fibroblasts and the heterogeneity of the fibroblast populations. In addition, pathway analysis of RNA-seq data highlighted putative bidirectional networks of fibroblast-to-SC signaling that predict a complementary, yet seemingly independent contribution of SCs and fibroblasts to nerve regeneration. In sum, combining MACS with immunochemical and transcriptomics approaches provides an ideal workflow to exhaustively assess the identity, the stage of differentiation and functional features of highly purified cells from human peripheral nerve tissues.Fil: Peng, Kaiwen. Indiana University. School of Medicine; Estados Unidos. Nanfang Hospital; ChinaFil: Sant, David. University of Utah; Estados Unidos. Miami University. School of Medicine; Estados UnidosFil: Andersen, Natalia Denise. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Miami University. School of Medicine; Estados UnidosFil: Silvera, Risset. Miami University. School of Medicine; Estados UnidosFil: Camarena, Vladimir. Miami University. School of Medicine; Estados UnidosFil: Piñero, Gonzalo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Miami University. School of Medicine; Estados UnidosFil: Graham, Regina. Miami University. School of Medicine; Estados UnidosFil: Khan, Aisha. Miami University. School of Medicine; Estados UnidosFil: Xu, Xiao Ming. Indiana University. School of Medicine; Estados UnidosFil: Wang, Gaofeng. Miami University. School of Medicine; Estados UnidosFil: Monje, Paula. Indiana University. School of Medicine; Estados Unidos. Miami University. School of Medicine; Estados Unido