Los derechos humanos en México : ¿retórica o compromiso?

Nacionalidad de la autora: mexicana.Con base en fuentes documentales y en perspectiva histórica, se hace un análisis de las prácticas y discurso de derechos humanos de los diferentes gobiernos mexicanos y su efecto en la situación de los derechos humanos en México. Primero se expone el marco conceptual de la socialización de las normas, el surgimiento de la red trasnacional de cabildeo e influencia, el efecto bumerang y, la teoría del espiral; se describe el surgimiento y trabajo de la red en México a lo largo de tres sexenios (Salinas 1989-1994; Zedillo 1995-2000 y Fox 2001–2006) y las respuestas o cambios en dichos gobiernos a la presión internacional y se evalúa la pertinencia del modelo para México mediante unas conclusiones analíticas señalando los principales problemas para aplicar el modelo a México, debido a que los indicadores para colocar a un país en una etapa específica del modelo del espiral, no aplican tan linealmente para este caso

Transcription factors in metastatic colorectal cancer [Running title]

44 p.-7 fig.We investigated new transcription and splicing factors associated with the metastatic phenotype in colorectal cancer. A concatenated tandem array of consensus transcription factor (TF)-response elements was used to pull down nuclear extracts in two different pairs of colorectal cancer cells, KM12SM/KM12C and SW620/480, genetically related but differing in metastatic ability. Proteins were analyzed by label-free LC-MS and quantified with MaxLFQ. We found 240 proteins showing a significant dysregulation in highly metastatic KM12SM cells relative to nonmetastatic KM12C cells and 257 proteins in metastatic SW620 versus SW480. In both cell lines there were similar alterations in genuine TFs and components of the splicing machinery like UPF1, TCF7L2/TCF-4, YBX1, or SRSF3. However, a significant number of alterations were cell-line specific. Functional silencing of MAFG, TFE3, TCF7L2/TCF-4, and SRSF3 in KM12 cells caused alterations in adhesion, survival, proliferation, migration, and liver homing, supporting their role in metastasis. Finally, we investigated the prognostic value of the altered TFs and splicing factors in cancer patients. SRSF3 and SFPQ showed significant prognostic value. We observed that SRSF3 displayed a gradual loss of expression associated with cancer progression. Loss of SRSF3 expression was significantly associated with poor survival and shorter disease-free survival, particularly in early stages, in colorectal cancer.This research was supported by grants BIO2015-66489-R from the MINECO, Foundation Ramón Areces and PRB2 (IPT13/0001-ISCIIISGEFI/FEDER).Peer reviewe

Emoticómic

La introducción de las tecnologías en el proceso de enseñanza y aprendizaje ha supuesto una rápida adaptación por parte del alumnado, el profesorado e incluso los padres. Este hecho ha provocado que hayan proliferado una serie de emociones con las que hay que lidiar. Este cómic comienza haciendo un recorrido por algunas de las emociones, tanto positivas como negativas, que afectan a los alumnos en la vida diaria en la escuela y especialmente en el uso de las tecnologías y, posteriormente, plantea algunas claves y orientaciones dirigidas a los alumnos, los docentes y las familias, para hacer frente a estas emociones para regularlas y controlarlas cuando se usan las tecnologías de la informaciónES

Early Colorectal Cancers Provide New Evidence for a Lynch Syndrome-to-CMMRD Phenotypic Continuum

International audienceLynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, caused by heterozygous mutations in the mismatch repair (MMR) genes. Biallelic mutations in these genes lead however, to constitutive mismatch repair deficiency (CMMRD). In this study, we follow the diagnostic journey of a 12-year old patient with CRC, with a clinical phenotype overlapping CMMRD. We perform molecular and functional assays to discard a CMMRD diagnosis then identify by exome sequencing and validation in a cohort of 134 LS patients, a candidate variant in the MLH1 UTR region in homozygosis. We propose that this variant, together with other candidates, could be responsible for age-of-onset modulation. Our data support the idea that low-risk modifier alleles may influence early development of cancer in LS leading to a LS-to-CMMRD phenotypic continuum. Therefore, it is essential that larger efforts are directed to the identification and study of these genetic modifiers, in order to provide optimal cancer prevention strategies to these patients

Children living with HIV in Europe: do migrants have worse treatment outcomes?

International audienceTo assess the effect of migrant status on treatment outcomes among children living with HIV in Europe