Sleep Disruption Medical Intervention Forecasting (SDMIF) Module for the Integrated Medical Model

The NASA Integrated Medical Model (IMM) assesses the risk, including likelihood and impact of occurrence, of all credible in-flight medical conditions. Fatigue due to sleep disruption is a condition that could lead to operational errors, potentially resulting in loss of mission or crew. Pharmacological consumables are mitigation strategies used to manage the risks associated with sleep deficits. The likelihood of medical intervention due to sleep disruption was estimated with a well validated sleep model and a Monte Carlo computer simulation in an effort to optimize the quantity of consumables. METHODS: The key components of the model are the mission parameter program, the calculation of sleep intensity and the diagnosis and decision module. The mission parameter program was used to create simulated daily sleep/wake schedules for an ISS increment. The hypothetical schedules included critical events such as dockings and extravehicular activities and included actual sleep time and sleep quality. The schedules were used as inputs to the Sleep, Activity, Fatigue and Task Effectiveness (SAFTE) Model (IBR Inc., Baltimore MD), which calculated sleep intensity. Sleep data from an ISS study was used to relate calculated sleep intensity to the probability of sleep medication use, using a generalized linear model for binomial regression. A human yes/no decision process using a binomial random number was also factored into sleep medication use probability. RESULTS: These probability calculations were repeated 5000 times resulting in an estimate of the most likely amount of sleep aids used during an ISS mission and a 95% confidence interval. CONCLUSIONS: These results were transferred to the parent IMM for further weighting and integration with other medical conditions, to help inform operational decisions. This model is a potential planning tool for ensuring adequate sleep during sleep disrupted periods of a mission

2015-2016 Philharmonia No. 1

Concert Date & Time: October 3, 2015 at 7:30 PM | October 4, 2015 at 4:00PM Program Don Quixote: Fantastic Variations on a Theme of Knightly Character, op. 35 / Richard Strauss Suite No. 2 from El Sombrero de tres picos (The Three-cornered Hat) / Manuel de Falla Conga for Orchestra / Miguel del Aguilahttps://spiral.lynn.edu/conservatory_philharmonia/1005/thumbnail.jp

Poster Session

Video provided is of MacKenzie Paul\u27s presentation. Abstracts Humanities Emma Beeler, Mississippi University for Women Adultery and Fidelity in the Lais of Marie de France Using both literary and historical analysis, I will examine contrasting depictions of adultery and fidelity within the lais written by 12th-century poet Marie de France. A lai is a type of narrative poem, ranging in length from 118 to 1184 lines. Many of Marie de France’s lais follow the literary trope known as courtly love; however, the reader is encouraged to sympathize with different characters depending on the lai. In some lais, the reader is encouraged to sympathize with the adulterous spouse, and in others, with the faithful spouse. To understand these different depictions, I will consider Medieval marriage law, church doctrine, and social factors, as well as literary aspects of the lais. Social Sciences Maddison Caldwell, Northeast Mississippi Community College Parenting Styles: Effects on Lifelong Growth This project will examine parenting styles and how each can affect lifelong development. The parenting styles authoritative, authoritarian, permissive, and uninvolved will be explored. This project will require extensive analysis through different studies and scholarly articles. Parenting styles affect a child’s behavior, social competence, personality, well-being, and career choices. A parent’s choice of a parenting style affects their child their whole entire life. The authoritative parenting style was found to be the most beneficial style that can be used by a parent, while the authoritarian style was prone to cause conflict within the family. When the permissive parenting style is used, children were found to not set boundaries for themselves. Lasty, the uninvolved parenting styles causes relationship difficulties the child inhibits. I will also include a graph to show and explain how the different styles affect different aspects of life. This project clearly explains the four parenting styles and how they affect lifelong development throughout a child’s life. MacKenzie Paul, Mississippi State University To Sweeten or Not to Sweeten: The Unique Impact of Emotional Support and Fatalism on Sugar Consumption Among Southeastern Native Americans In 2020, 14.8% of Mississippi adults and 12.6% of Louisiana adults reported having diabetes, as compared to the national average of 10.8%. Furthermore, Native Americans of Mississippi and Louisiana experience disproportionately higher diabetes prevalence at 38% and 34% respectively. Research has shown that excessive sugar consumption is associated with an increased risk of developing type-2 diabetes. Psychosocial variables such as chronic disease fatalism and emotional support may also influence diabetes self-care behaviors including food consumption patterns like sugar intake. Therefore, the objective of this study is to examine the impact of emotional support and fatalism on sugar consumption among Southeastern Native Americans. The Mississippi INBRE Telenutrition Center Community Health Assessment Survey was utilized to survey 368 adults from Mississippi and Louisiana. Eighty-one of the participants, who self-identified as Native American, were included in the study. A hierarchal linear regression analysis showed that increased emotional support was significantly related with reduced sugar consumption (β = -0.307, p = 0.004), and increased fatalism was significantly associated with elevated sugar consumption (β = 0.286, p = 0.007). More research is necessary to substantiate this relationship among a broader Southeastern Native American population and identify potential implications for diabetes management in this disparate group. STEM Shirli Salihaj, Mississippi University for Women Surface Reconstruction via the Curvature Interpolation Method The surface reconstruction for scattered data becomes a problem as the number of sample points increases to construct a continuous function that satisfies given conditions in three dimensions (3D). However, it is known that this problem does not have a definite solution and therefore requires numerical approximations. This project studies the Curvature Interpolation Method with Iterative Refinement (IR-CIM), an innovative algorithm that produces smooth and reliable surfaces from 3D point cloud data. I use pre-collected data by Light Detection and Ranging (LiDAR) technology and MATLAB to perform digital image processing. I first study interpolation on 2D data and then practice with 3D data sets with simple interpolation methods to practice the implementation of IR-CIM for LiDAR data. The research objective is to compare the efficiency and accuracy of the IR-CIM with the inverse distance weighting method. Furthermore, I will verify that the IR-CIM outperforms the inverse distance weighting method and show that it is a good alternative to replace the outdated algorithm when processing LiDAR data. Sara Lynn Sligh, Mississippi University for Women Effects of Chloride Ion Channel Activators on CFTR Expression The purpose of this research is to determine the effects of newly synthesized compounds, which have shown the ability to function as chloride ion channel activators, on the expression of Cystic Fibrosis Transmembrane-conductance Regulator (CFTR), a protein found within Cystic Fibrosis Bronchial Epithelial (CFBE) cells. Mutations in the CFTR protein cause the genetic disease Cystic Fibrosis (CF). To conduct this research, a tissue culture utilizing three main cell lines is being performed. The three main cell lines are CFBE-wild type, CFBE-ΔF508, and CFBE-41ø. CFBE-wildtype contains the normal, functional CFTR protein. CFBE-ΔF508 contains the nonfunctional CFTR protein as well as the mutation that is responsible for over 70% of CF cases. CFBE-41ø is the parental cell line and will function as a negative control. The main method used to determine the effects of the new compounds is Immunofluorescence Cytochemistry. Through this method, images are generated that identify the location of CFTR within the cell while maintaining the cell’s integrity. These experiments are being run weekly to generate data via images captured by an immunofluorescent microscope. Stephen Trest, Mississippi Gulf Coast Community College The Bonnet Carre Spillway and Its Effects on South Mississippi\u27s Economy The Bonnet Carre Spillway is a flood control system located in Saint Charles Parish, Louisiana. In recent years, this spillway has been opened longer and more often than it had in the past. As a result, there has been a much larger quantity of fresh water in the Mississippi Sound, and this has killed a large quantity of marine life. This seriously impacts our local fishing economy. Many fishers have had to take entire seasons off because it would not be profitable to operate in these conditions. On top of the effects on fishing, the excess fresh water contributes to the flesh-eating bacteria outbreak which has plagued our beaches for years. 2019 was the first time in history that the Bonnet Carre was opened twice in one year, and it was also a particularly bad year for flesh-eating bacteria on our beaches; tourism is a major industry on the coast, and the beach is the main reason for that. We need a healthy Mississippi Sound for our coastal economy to thrive, and the repeated flooding of fresh water through the Bonnet Carre is negatively affecting that. Since flooding New Orleans is not an option, I will go over the other possible solution: restoring the Mississippi River Delta

Estimating the Need for Medical Intervention due to Sleep Disruption on the International Space Station

During ISS and shuttle missions, difficulties with sleep affect more than half of all US crews. Mitigation strategies to help astronauts cope with the challenges of disrupted sleep patterns can negatively impact both mission planning and vehicle design. The methods for addressing known detrimental impacts for some mission scenarios may have a substantial impact on vehicle specific consumable mass or volume or on the mission timeline. As part of the Integrated Medical Model (IMM) task, NASA Glenn Research Center is leading the development of a Monte Carlo based forecasting tool designed to determine the consumables required to address risks related to sleep disruption. The model currently focuses on the International Space Station and uses an algorithm that assembles representative mission schedules and feeds this into a well validated model that predicts relative levels of performance, and need for sleep (SAFTE Model, IBR Inc). Correlation of the resulting output to self-diagnosed needs for hypnotics, stimulants, and other pharmaceutical countermeasures, allows prediction of pharmaceutical use and the uncertainty of the specified prediction. This paper outlines a conceptual model for determining a rate of pharmaceutical utilization that can be used in the IMM model for comparison and optimization of mitigation methods with respect to all other significant medical needs and interventions

Generalized support and formal development of constraint propagators

Constraint programming is a family of techniques for solving combinatorial problems, where the problem is modelled as a set of decision variables (typically with finite domains) and a set of constraints that express relations among the decision variables. One key concept in constraint programming is propagation: reasoning on a constraint or set of constraints to derive new facts, typically to remove values from the domains of decision variables. Specialized propagation algorithms (propagators) exist for many classes of constraints.The concept of support is pervasive in the design of propagators. Traditionally, when a domain value ceases to have support, it may be removed because it takes part in no solutions. Arc-consistency algorithms such as AC2001 make use of support in the form of a single domain value. GAC algorithms such as GAC-Schema use a tuple of values to support each literal. We generalize these notions of support in two ways. First, we allow a set of tuples to act as support. Second, the supported object is generalized from a set of literals (GAC-Schema) to an entire constraint or any part of it.We design a methodology for developing correct propagators using generalized support. A constraint is expressed as a family of support properties, which may be proven correct against the formal semantics of the constraint. We show how to derive correct propagators from the constructive proofs of the support properties. The framework is carefully designed to allow efficient algorithms to be produced. Derived algorithms may make use of dynamic literal triggers or watched literals for efficiency. Finally, three case studies of deriving efficient algorithms are given

2013-2014 Lynn Philharmonia Season Program

Wind Ensemble September 15, 2013 at 4:00 PM The Wind Symphony, Movement 2 Kenneth Amis, director and conductor Symphonie Militaire / François Joseph Gossec -- Sinfonietta, op. 188 (1873) / Joseph Joachim Raff -- La Vita Symphony in Three Scenes (1998) / Yasuhide Ito -- Symphony for Winds and Percussion / Donald Grantham Philharmonia No. 1 October 5, 2013 at 7:30 PM and October 6, 2013 at 4:00 PM Jon Robertson, guest conductor Crown Imperial March / William Walton -- Symphony No. 38 in D major, K. 504 ( Prague ) / Wolfgang Amadeus Mozart -- Symphony No. 4 in E-flat Major (1888 version) / Anton Bruckner Philharmonia No. 2 October 26, 2013 at 7:30 PM and October 27, 2013 at 4:00 PM Jon Robertson, guest conductor Orchestral Suite No. 3 in D major, BWV 1068 / Johann Sebastian Bach -- Symphony No. 1 in D major, op. 25 ( Classical ) / Sergei Prokofiev -- Symphony No. 9 in E Minor, op. 95 ( From the New World ) / Antonín Dvořák Philharmonia No. 3 November 16, 2013 at 7:30 PM and November 17, 2013 at 4:00 PM 2013 Concerto Competition Winners Guillermo Figueroa, conductor ; Doniyor Zuparov, cello ; Anna Brumbaugh, clarinet ; Vladislav Kosminov, piano ; Timothy Nemzin, trumpet ; Brenton Caldwell, viola Overture to Benvenuto Cellini, op. 23 / Hector Berlioz -- Concerto in E Minor for Violoncello, op. 61 / Edward Elgar -- Concerto Fantasia on Motives from Verdi\u27s Opera Rigoletto / Luigi Bassi, orchestrated by Kenneth Lee Richmond -- Capriccio Espagnol, op. 34 / Nicolai Rimsky-Korsakov -- Concerto No. 1 in C Minor for Piano, op. 35 / Dmitri Shostakovich -- Concerto for Viola (1962 version) / William Walton Philharmonia No. 4 January 18, 2014 at 7:30 PM and January 19, 2014 at 4:00 PM Guillermo Figueroa, conductor ; Carol Cole, violin ; David Cole, cello Overture to Le Nozze di Figaro (The Marriage of Figaro), K. 492 / Wolfgang Amadeus Mozart -- Concerto for Violin, Cello and Orchestra in A Minor, op. 102 / Johannes Brahms -- Fandangos / Roberto Sierra -- Suite from Der Rosenkavalier (The Knight of the Rose), op. 59 / Richard Strauss Philharmonia No. 5 February 8, 2014 at 7:30 PM and February 9, 2014 at 4:00 PM Guillermo Figueroa, conductor Overture to Guillaume Tell (William Tell) / Gioachino Rossini -- Don Juan, op. 20 / Richard Strauss -- Symphony No. 4 in F Minor, op. 36 / Pyotr Ilyich Tchaikovsky Philharmonia No. 6 March 22, 2014 at 7:30 PM and March 23, 2014 at 4:00 PM Guillermo Figueroa, conductor ; Abigail Santos Villalobos, soprano ; Gabriela García, mezzo-soprano ; Master Chorale of South Florida ; Brett Karlin, artistic director Symphony No. 2 in C minor ( Resurrection ) / Gustav Mahlerhttps://spiral.lynn.edu/conservatory_philharmonia/1017/thumbnail.jp

Mercury Levels in an Urban Pregnant Population in Durham County, North Carolina

The adverse effects of prenatal mercury exposure, most commonly resulting from maternal fish consumption, have been detected at very low exposure levels. The omega-3 fatty acids found in fish, however, have been shown to support fetal brain and vision development. Using data from a prospective, cohort study of pregnant women from an inland area in the US South, we sought to understand the fish consumption habits and associated mercury levels across subpopulations. Over 30% of women had at least 1 μg/L of mercury in their blood, and about 2% had blood mercury levels above the level of concern during pregnancy (≥3.5 μg/L). Mercury levels were higher among Asian/Pacific Islander, older, higher educated, and married women. Fish consumption from any source was reported by 2/3 of the women in our study, with older women more likely to consume fish. Despite eating more fish meals per week, lower income, lower educated women had lower blood mercury levels than higher income, higher educated women. This suggests the different demographic groups consume different types of fish. Encouraging increased fish consumption while minimizing mercury exposure requires careful crafting of a complex health message