Tributación : Incentivos tributarios a la exploración y explotación de las minas en Nicaragua

Nicaragua es un país rico en yacimientos minerales, para los cuales el gobierno ofrece oportunidades de invertir en la exploración y explotación de estos, brindando un sinnúmero de incentivos tributarios con el objetivo de beneficiar a las inversiones que en su mayoría son de capital extranjero. El presente trabajo propone un análisis desde una perspectiva más formal en el que el gobierno de Nicaragua presente una buena base de incentivos cuando de lo tributario se refiere en pro del beneficio de las empresas inversionista en este sector los cuales van desde un pago mínimo establecido por uso del área para la exploración y exploración de estos materiales preciosos hasta la suspensión de impuestos fiscales y municipales por tratarse de un sector económica que genera fuertes ingresos al país mediante la producción y exportación de dichos materiales. Se preparo un caso práctico donde se estableció la aprobación de una concesión minera a una empresa inversionista de capital extranjero por 10 años donde se realizo una proyección de los costos y gastos de inversión en la instalación y funcionamiento del proyecto hasta por la cantidad de 5 millones de dólares aplicando en esa varios de los beneficios que el gobierno de Nicaragua brinda a estos, lo cual dio como resultado un retribución tributaria en incentivos hasta por 500,000 dólares equivalente al 10% de la inversión proyectada la cual presentada una rentabilidad aceptable en el mercado nacional. Así mismo se tomó en consideración del tema de la protección de los recursos naturales ante los trabajos de minería donde hay leyes y reglamentos los cuales deben ser acatados por dichos concesionarias mineras en Nicaragua

Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein

RNA-dependent RNA polymerases (RdRps) play a key role in the life cycle of RNA viruses and impact their immunobiology. The arenavirus lymphocytic choriomeningitis virus (LCMV) strain Clone 13 provides a benchmark model for studying chronic infection. A major genetic determinant for its ability to persist maps to a single amino acid exchange in the viral L protein, which exhibits RdRp activity, yet its functional consequences remain elusive. To unravel the L protein interactions with the host proteome, we engineered infectious L protein-tagged LCMV virions by reverse genetics. A subsequent mass-spectrometric analysis of L protein pulldowns from infected human cells revealed a comprehensive network of interacting host proteins. The obtained LCMV L protein interactome was bioinformatically integrated with known host protein interactors of RdRps from other RNA viruses, emphasizing interconnected modules of human proteins. Functional characterization of selected interactors highlighted proviral (DDX3X) as well as antiviral (NKRF, TRIM21) host factors. To corroborate these findings, we infected Trim21-/-mice with LCMV and found impaired virus control in chronic infection. These results provide insights into the complex interactions of the arenavirus LCMV and other viral RdRps with the host proteome and contribute to a better molecular understanding of how chronic viruses interact with their host

Feeding Induced by Cannabinoids Is Mediated Independently of the Melanocortin System

Cannabinoids, the active components of marijuana, stimulate appetite, and cannabinoid receptor-1 (CB1-R) antagonists suppress appetite and promote weight loss. Little is known about how CB1-R antagonists affect the central neurocircuitry, specifically the melanocortin system that regulates energy balance

Monoculture of Leafcutter Ant Gardens

Background -- Leafcutter ants depend on the cultivation of symbiotic Attamyces fungi for food, which are thought to be grown by the ants in single-strain, clonal monoculture throughout the hundreds to thousands of gardens within a leafcutter nest. Monoculture eliminates cultivar-cultivar competition that would select for competitive fungal traits that are detrimental to the ants, whereas polyculture of several fungi could increase nutritional diversity and disease resistance of genetically variable gardens. Methodology/Principal Findings -- Using three experimental approaches, we assessed cultivar diversity within nests of Atta leafcutter ants, which are most likely among all fungus-growing ants to cultivate distinct cultivar genotypes per nest because of the nests' enormous sizes (up to 5000 gardens) and extended lifespans (10–20 years). In Atta texana and in A. cephalotes, we resampled nests over a 5-year period to test for persistence of resident cultivar genotypes within each nest, and we tested for genetic differences between fungi from different nest sectors accessed through excavation. In A. texana, we also determined the number of Attamyces cells carried as a starter inoculum by a dispersing queens (minimally several thousand Attamyces cells), and we tested for genetic differences between Attamyces carried by sister queens dispersing from the same nest. Except for mutational variation arising during clonal Attamyces propagation, DNA fingerprinting revealed no evidence for fungal polyculture and no genotype turnover during the 5-year surveys. Conclusions/Significance -- Atta leafcutter ants can achieve stable, fungal monoculture over many years. Mutational variation emerging within an Attamyces monoculture could provide genetic diversity for symbiont choice (gardening biases of the ants favoring specific mutational variants), an analog of artificial selection.The research was supported by National Science Foundation awards DEB-0920138, DEB-0639879, and DEB-0110073 to UGM; DEB-0949689 to T.R. Schultz, N. Mehdiabadi, and UGM; and a Fellowship (02/05) from the Conselho Nacional de Desenvolvimento Científico e Tecnológico to AR. The funding agencies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Biological Sciences, School o

A facility and community-based assessment of scabies in rural Malawi.

Background Scabies is a neglected tropical disease of the skin, causing severe itching, stigmatizing skin lesions and systemic complications. Since 2015, the DerMalawi project provide an integrated skin diseases clinics and Tele-dermatology care in Malawi. Clinic based data suggested a progressive increase in scabies cases observed. To better identify and treat individuals with scabies in the region, we shifted from a clinic-based model to a community based outreach programme. Methodology/principal findings From May 2015, DerMalawi project provide integrated skin diseases and Tele-dermatological care in the Nkhotakota and Salima health districts in Malawi. Demographic and clinical data of all patients personally attended are recorded. Due to a progressive increase in the number of cases of scabies the project shifted to a community-based outreach programme. For the community outreach activities, we conducted three visits between 2018 to 2019 and undertook screening in schools and villages of Alinafe Hospital catchment area. Treatment was offered for all the cases and school or household contacts. Scabies increased from 2.9% to 39.2% of all cases seen by the DerMalawi project at clinics between 2015 to 2018. During the community-based activities approximately 50% of the population was assessed in each of three visits. The prevalence of scabies was similar in the first two rounds, 15.4% (2392) at the first visit and 17.2% at the second visit. The prevalence of scabies appeared to be lower (2.4%) at the third visit. The prevalence of impetigo appeared unchanged and was 6.7% at the first visit and 5.2% at the final visit. Conclusions/significance Prevalence of scabies in our setting was very high suggesting that scabies is a major public health problem in parts of Malawi. Further work is required to more accurately assess the burden of disease and develop appropriate public health strategies for its control

Mainstreaming Community Energy: Is the Renewable Energy Directive a Driver for Renewable Energy Communities in Germany and Italy?

By 30 June 2021, EU Member States were expected to transpose the recast Renewable Energy Directive (RED II) which includes provisions for renewable energy communities (RECs) and to develop an enabling framework to promote the development of RECs. Although there is a growing number of studies analysing the emergence of various forms of community energy, comparative studies investigating the transposition and creation of enabling frameworks for RECs in a multi-level governance (MLG) perspective are scarce. This article examines the transposition in Germany and Italy and compares elements of the respective enabling frameworks. Key methods include context and MLG analysis combined with methods of descriptive (legal) studies. Insights and participatory observations of the stakeholder desks established in the Horizon2020 project COME RES complement the spectrum of methods deployed. Although community energy development is more advanced in Germany, the transposition of the RED II provisions has been slow and piecemeal so far. Conversely, in Italy, RED II played a catalyst role; the transposition has been rather dynamic and encouraged a continuous growth of REC initiatives. Nevertheless, a widespread uptake of RECs requires structural adjustments of the governance system in both countries and attention to MLG as well as vertical policy coordination

Mainstreaming Community Energy: Is the Renewable Energy Directive a Driver for Renewable Energy Communities in Germany and Italy?

By 30 June 2021, EU Member States were expected to transpose the recast Renewable Energy Directive (RED II) which includes provisions for renewable energy communities (RECs) and to develop an enabling framework to promote the development of RECs. Although there is a growing number of studies analysing the emergence of various forms of community energy, comparative studies investigating the transposition and creation of enabling frameworks for RECs in a multi-level governance (MLG) perspective are scarce. This article examines the transposition in Germany and Italy and compares elements of the respective enabling frameworks. Key methods include context and MLG analysis combined with methods of descriptive (legal) studies. Insights and participatory observations of the stakeholder desks established in the Horizon2020 project COME RES complement the spectrum of methods deployed. Although community energy development is more advanced in Germany, the transposition of the RED II provisions has been slow and piecemeal so far. Conversely, in Italy, RED II played a catalyst role; the transposition has been rather dynamic and encouraged a continuous growth of REC initiatives. Nevertheless, a widespread uptake of RECs requires structural adjustments of the governance system in both countries and attention to MLG as well as vertical policy coordination