Intentional Forgetting Benefits From Thought Substitution

This study provides both experimental and correlational evidence that forgetting in the think/no-think paradigm (Anderson & Green, 2001) is sensitive to the substitution of thoughts about new events forthoughts that are to be suppressed. All the participants learned a list of adjective-noun pairs. Then the adjectives were presented as cues for recalling half of the nouns and as cues for suppressing the other half, 0, 2, or 12 times. Aided participants were provided with substitute nouns, to use during suppression. On a final test that requested recall of all initially learned nouns, aided participants showed evidence of below-baseline forgetting of suppressed nouns. Unaided participants produced below-baseline forgetting only if their later self-reports indicated that they had complied relatively well with instructions for suppression. Independently, forgetting in the unaided condition was more successful when the participants reportedly thought about something else during suppression trials. In general, the use of self-initiated strategies seems to affect the degree of forgetting in the think/no-think paradigm

Subtracting Race from the Reasonable Calculus : An End to Racial Profiling? \u3cem\u3eUnited States V. Montero-Camargo\u3c/em\u3e 208 F.3D 1122 (9th Cir. 2000) Cert. Denied Sub Nom

This Case Note presents the facts of Montero-Camargo, describes the decision of the Ninth Circuit Court in historical context, and analyzes the effect of the Court\u27s holding. The Case Note argues that while the Ninth Circuit\u27s decision to prohibit the use of race as a factor in determining the reasonableness calculus in traffic stops is progressive in spirit, implementing the decision will be difficult. Thus far, mechanisms designed to limit officers\u27 use of race in traffic stops have been ineffective and have left victims with little recourse, resulting in a disproportionate number of innocent African American and Latino drivers being stopped pretextually

Cloud resource orchestration in the multi-cloud landscape: a systematic review of existing frameworks

The number of both service providers operating in the cloud market and customers consuming cloud-based services is constantly increasing, proving that the cloud computing paradigm has successfully delivered its potential. Nevertheless, the unceasing growth of the cloud market is posing hard challenges on its participants. On the provider side, the capability of orchestrating resources in order to maximise profits without failing customers’ expectations is a matter of concern. On the customer side, the efficient resource selection from a plethora of similar services advertised by a multitude of providers is an open question. In such a multi-cloud landscape, several research initiatives advocate the employment of software frameworks (namely, cloud resource orchestration frameworks - CROFs) capable of orchestrating the heterogeneous resources offered by a multitude of cloud providers in a way that best suits the customer’s need. The objective of this paper is to provide the reader with a systematic review and comparison of the most relevant CROFs found in the literature, as well as to highlight the multi-cloud computing open issues that need to be addressed by the research community in the near future

ARE SUSCEPTIBILITY to INFECTIVE ENDOCARDITIS and EFFECTIVENESS of ANTIBIOTIC PROPHYLAXIS LINKED to FLUCTUATIONS of the IMMUNE SYSTEM? A NOVEL HYPOTHESIS

Introduction: An amendment incorporated into the 2007 AHA and 2009 ESC guidelines on infective endocarditis led to a substantial restriction in indications for the administration of antibiotic prophylaxis. This may have resulted in a subsequent steady increase in the number of cases of infective endocarditis worldwide. Methods: It has been hypothesised that susceptibility to infective endocarditis, together with effectiveness of antibiotic prophylaxis, may be linked to fluctuations of the immune system. Throughout a person’s lifetime, individual susceptibility to infective endocarditis may vary in an identical situation of risk. As a consequence, a personalised targeted approach should be adopted when prescribing antibiotic prophylaxis to prevent onset of endocarditis, taking into account a series of factors including age, comorbidities, cortisol levels, and ethnicity. Children affected by bicuspid aortic valve and injection drug users are amongst the newly-emerging higher risk populations. Conclusion: This up-to-dated narrative review summarizes all the available scientific evidence concerning the variable influence of the immune system on susceptibility to infective endocarditis

Laparoscopic nephrectomy in crossed fused kidney ectopia with severe hydronephrosis in 2 year-old child

Introduction: There are no specific recommendations for the surgical management of crossed fused renal ectopia (CFRE), but a laparoscopy has been proposed in a limited number of children. We report the case of a complex CFRE with severe hydronephrosis in a child treated by laparoscopic nephrectomy. Case report: A 2-year-old boy was admitted for hip and abdominal pain. A CFRE was diagnosed. Laparoscopic nephrectomy was suggested. The right crossed ectopic kidney appeared fused at its upper pole to the lower pole of the left kidney. The left kidney was in total rotation postero superiorly The left ureter crossing over the ectopic dilated right pelvis deliniated the fusion line between both kidneys. The right ureter was dissected distally. The right artery and vein were dissected and the right kidney pelvis opened making the separation of the kidneys easier and so reducing the danger of damaging the lower pole of the left kidney. During the dissection an aberrant vein arising from the left iliac vein and draining from both kidneys was identified. The right vein was dissected preserving the left vein, and the nephrectomy completed. Conclusions: Laparoscopy is a recommended option to treat CFRE, offering all advantages of this approach

Hydrological control of soil thickness spatial variability on the initiation of rainfall-induced shallow landslides using a three-dimensional model

Thickness and stratigraphic settings of soils covering slopes potentially control susceptibility to initiation of rainfall-induced shallow landslides due to their local effect on slope hydrological response. Notwithstanding the relevance of the assessment of hazard to shallow landsliding at a distributed scale by approaches based on a coupled modelling of slope hydrological response and slope stability, the spatial variability of soil thickness and stratigraphic settings are factors poorly considered in the literature. Under these premises, this paper advances the well-known case study of rainfall-induced shallow landslides involving ash-fall pyroclastic soils covering the peri-Vesuvian mountains (Campania, southern Italy). In such a unique geomorphological setting, the soil covering is formed by alternating loose ash-fall pyroclastic deposits and paleosols, with high contrasts in hydraulic conductivity and total thickness decreasing as the slope angle increases, thus leading to the establishment of lateral flow and an increase of pore water pressure in localised sectors of the slope where soil horizon thickness is less. In particular, we investigate the effects, on hillslope hydrological regime and slope stability, of irregular bedrock topography, spatial variability of soil thickness and vertical hydraulic heterogeneity of soil horizons, by using a coupled three-dimensional hydrological and a probabilistic infinite slope stability model. The modelling is applied on a sample mountain catchment, located on Sarno Mountains (Campania, southern Italy), and calibrated using physics-based rainfall thresholds derived from the literature. The results obtained under five simulated constant rainfall intensities (2.5, 5, 10, 20 and 40 mm h−1) show an increase of soil pressure head and major failure probability corresponding to stratigraphic and morphological discontinuities, where a soil thickness reduction occurs. The outcomes obtained from modelling match the hypothesis of the formation of lateral throughflow due to the effect of intense rainfall, which leads to the increase of soil water pressure head and water content, up to values of near-saturation, in narrow zones of the slope, such as those of downslope reduction of total soil thickness and pinching out of soil horizons. The approach proposed can be conceived as a further advance in the comprehension of slope hydrological processes at a detailed scale and their effects on slope stability under given rainfall and antecedent soil hydrological conditions, therefore in predicting the most susceptible areas to initiation of rainfall-induced shallow landslides and the related I-D rainfall thresholds. Results obtained demonstrate the occurrence of a slope hydrological response depending on the spatial variability of soil thickness and leading to focus slope instability in specific slope sectors. The approach proposed is conceived to be potentially exportable to other slope environments for which a spatial modelling of soil thickness would be possible

High-resolution tracking in a GEM-Emulsion detector

SHiP (Search for Hidden Particles) is a beam dump experiment proposed at the CERN SPS aiming at the observation of long lived particles very weakly coupled with ordinary matter mostly produced in the decay of charmed hadrons. The beam dump facility of SHiP is also a copious factory of neutrinos of all three kinds and therefore a dedicated neutrino detector is foreseen in the SHiP apparatus. The neutrino detector exploits the Emulsion Cloud Chamber technique with a modular structure, alternating walls of target units and planes of electronic detectors providing the time stamp to the event. GEM detectors are one of the possible choices for this task. This paper reports the results of the first exposure to a muon beam at CERN of a new hybrid chamber, obtained by coupling a GEM chamber and an emulsion detector. Thanks to the micrometric accuracy of the emulsion detector, the position resolution of the GEM chamber as a function of the particle inclination was evaluated in two configurations, with and without the magnetic fiel

Quaternary deformation in SE Sicily: Insights into the life and cycles of forebulge fault systems

Integrated geological, geomorphological, and differential interferometry synthetic aperture radar (DInSAR) data are used to constrain the timing and modes of activity of Quaternary fault systems in the Hyblean Plateau. This area, which represents a unique natural laboratory for studying surface deformation in relation to deep slab dynamics, has grown since middle Miocene times as a doubly plunging forebulge associated with slab rollback during NW-directed subduction. Bimodal extension has produced two mutually orthogonal normal fault systems. The detailed stratigraphic record provided by synrift sediments and postrift marine terraces allowed us to define the timing of activity of an early Pleistocene, flexure-related fault system, thus constraining the duration of a typical foreland extensional tectonic event to ~1.5 m.y. Subsequent late Quaternary to present deformation was dominated by strike-slip faulting associated with NW-oriented horizontal compression. During this latest stage, regional uplift progressively increased toward the thrust front to the NW and was accompanied by differential uplift accommodated by dip-slip components of motion along active NNW-trending faults. The general active tectonic setting of the study area, characterized by NW-oriented horizontal compression consistent with major plate convergence, and the regional uplift pattern can both be explained within the framework of intraplate shortening and foreland rebound following complete slab detachment, a major geodynamic event interpreted to have taken place at ca. 0.7 Ma in southern Italy

Microenvironment in neuroblastoma: Isolation and characterization of tumor-derived mesenchymal stromal cells

Background: It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterized MSCs isolated and expanded from tumor tissues of pediatric patients diagnosed with neuroblastomas (NB-MSCs) to define interactions with the tumor microenvironment. Methods: Specimens were obtained from 7 pediatric patients diagnosed with neuroblastoma (NB). Morphology, immunophenotype, differentiation capacity, proliferative growth, expression of stemness and neural differentiation markers were evaluated. Moreover, the ability of cells to modulate the immune response, i.e. inhibition of phytohemagglutinin (PHA) activated peripheral blood mononuclear cells (PBMCs) and natural killer (NK) cytotoxic function, was examined. Gene expression profiles, known to be related to tumor cell stemness, Wnt pathway activation, epithelial-mesenchymal transition (EMT) and tumor metastasis were also evaluated. Healthy donor bone marrow-derived MSCs (BM-MSC) were employed as controls. Results: NB-MSCs presented the typical MSC morphology and phenotype. They showed a proliferative capacity superimposable to BM-MSCs. Stemness marker expression (Sox2, Nanog, Oct3/4) was comparable to BM-MSCs. NB-MSC in vitro osteogenic and chondrogenic differentiation was similar to BM-MSCs, but NB-MSCs lacked adipogenic differentiation capacity. NB-MSCs reached senescence phases at a median passage of P7 (range, P5-P13). NB-MSCs exhibited greater immunosuppressive capacity on activated T lymphocytes at a 1:2 (MSC: PBMC) ratio compared with BM-MSCs (p = 0.018). NK cytotoxic activity was not influenced by co-culture, either with BM-MSCs or NB-MSCs. Flow-cytometry cell cycle analysis showed that NB-MSCs had an increased number of cells in the G0-G1 phase compared to BM-MSCs. Transcriptomic profiling results indicated that NB-MSCs were enriched with EMT genes compared to BM-MSCs. Conclusions: We characterized the biological features, the immunomodulatory capacity and the gene expression profile of NB-MSCs. The NB-MSC gene expression profile and their functional properties suggest a potential role in promoting tumor escape, invasiveness and metastatic traits of NB cancer cells. A better understanding of the complex mechanisms underlying the interactions between NB cells and NB-derived MSCs should shed new light on potential novel therapeutic approaches

One step minilaparotomy-assisted transmesenteric portal vein recanalization combined with transjugular intrahepatic portosystemic shunt placement: A novel surgical proposal in pediatrics

Transjugular intrahepatic portosystemic shunt (TIPS) placement is a standard procedure for the treatment of portal hypertension complications. When this conventional approach is not feasible, alternative procedures for systemic diversion of portal blood have been proposed. A one-step interventional approach, combining minilaparotomy-assisted transmesenteric (MAT) antegrade portal recanalization and TIPS, is described in an adolescent with recurrent esophageal varice bleeding and portal cavernoma (PC). A 16-year-old girl was admitted to our Unit because of repeated bleeding episodes over a short period of time due to esophageal varices in the context of a PC. A portal vein recanalization through an ileocolic vein isolation with the MAT approach followed by TIPS during the same session was performed. In the case of failed portal recanalization, this approach, would also be useful for varice endovascular embolization. Postoperative recovery was uneventful. Treatment consisting of propanolol, enoxaparin and a proton pump inhibitor was prescribed after the procedure. One month post-op, contrast enhanced computed tomography confirmed the patency of the portal and intrahepatic stent grafts. No residual peritoneal fluid was detected nor opacification of the large varices. Endoscopy showed good improvement of the varices. Doppler ultrasound confirmed the accelerated flow in the portal stent and hepatopetal flow inside the intrahepatic portal branches. Three months post-op, TIPS maintained its hourglass shape despite a slight expansion. Portal hypertension and life threatening conditions related to PC would benefit from one-step portal recanalization. MAT-TIPS is feasible and safe for the treatment of PC even in children. This minimally invasive procedure avoids or delays surgical treatment or re-transplantation when necessary in pediatric patients