A review of the role of ultrasound biomicroscopy in glaucoma associated with rare diseases of the anterior segment

Ultrasound biomicroscopy is a non-invasive imaging technique, which allows high-resolution evaluation of the anatomical features of the anterior segment of the eye regardless of optical media transparency. This technique provides diagnostically significant information in vivo for the cornea, anterior chamber, chamber angle, iris, posterior chamber, zonules, ciliary body, and lens, and is of great value in assessment of the mechanisms of glaucoma onset. The purpose of this paper is to review the use of ultrasound biomicroscopy in the diagnosis and management of rare diseases of the anterior segment such as mesodermal dysgenesis of the neural crest, iridocorneal endothelial syndrome, phakomatoses, and metabolic disorders

A robust MPC approach for the rebalancing of mobility on demand systems

A control-oriented model for mobility-on-demand systems is here proposed. The system is first described through dynamical stochastic state-space equations, and then suitably simplified in order to obtain a controloriented model, on which two control strategies based on Model Predictive Control are designed. The first strategy aims at keeping the expected value of the number of vehicles parked in stations within prescribed bounds; the second strategy specifically accounts for stochastic fluctuations around the expected value. The model includes the possibility of weighting the control effort, leading to control solutions that may trade off efficiency and cost. The models and control strategies are validated over a dataset of logged trips of ToBike, the bike-sharing systems in the city of Turin, Italy

Separable Multipartite Mixed States - Operational Asymptotically Necessary and Sufficient Conditions

We introduce an operational procedure to determine, with arbitrary probability and accuracy, optimal entanglement witness for every multipartite entangled state. This method provides an operational criterion for separability which is asymptotically necessary and sufficient. Our results are also generalized to detect all different types of multipartite entanglement.Comment: 4 pages, 2 figures, submitted to Physical Review Letters. Revised version with new calculation

A model predictive control approach to optimally devise a two-dose vaccination rollout: A case study on COVID-19 in Italy

The COVID-19 pandemic has led to the unprecedented challenge of devising massive vaccination rollouts, toward slowing down and eventually extinguishing the diffusion of the virus. The two-dose vaccination procedure, speed requirements, and the scarcity of doses, suitable spaces, and personnel, make the optimal design of such rollouts a complex problem. Mathematical modeling, which has already proved to be determinant in the early phases of the pandemic, can again be a powerful tool to assist public health authorities in optimally planning the vaccination rollout. Here, we propose a novel epidemic model tailored to COVID-19, which includes the effect of nonpharmaceutical interventions and a concurrent two-dose vaccination campaign. Then, we leverage nonlinear model predictive control to devise optimal scheduling of first and second doses, accounting both for the healthcare needs and for the socio-economic costs associated with the epidemics. We calibrate our model to the 2021 COVID-19 vaccination campaign in Italy. Specifically, once identified the epidemic parameters from officially reported data, we numerically assess the effectiveness of the obtained optimal vaccination rollouts for the two most used vaccines. Determining the optimal vaccination strategy is nontrivial, as it depends on the efficacy and duration of the first-dose partial immunization, whereby the prioritization of first doses and the delay of second doses may be effective for vaccines with sufficiently strong first-dose immunization. Our model and optimization approach provide a flexible tool that can be adopted to help devise the current COVID-19 vaccination campaign, and increase preparedness for future epidemics

Data-driven extraction of uniformly stable and passive parameterized macromodels

A Robust algorithm for the extraction of reduced-order behavioral models from sampled frequency responses is proposed. The system under investigation can be any Linear and Time Invariant structure, although the main emphasis is on devices that are relevant for Signal and Power Integrity and RF design, such as electrical interconnects and integrated passive components. We assume that the device under modeling is parameterized by one or more design variables, which can be related to geometry or materials. Therefore, we seek for multivariate macromodels that reproduce the dynamic behavior over a predefined frequency band, with an explicit embedded dependence of the model equations on these external parameters. Such parameterized macromodels may be used to construct component libraries and prove very useful in fast system-level numerical simulations in time or frequency domain, including optimization, what-if, and sensitivity analysis. The main novel contribution is the formulation of a finite set of convex constraints that are applied during model identification, which provide sufficient conditions for uniform model stability and passivity throughout the parameter space. Such constraints are characterized by an explicit control allowing for a trade-off between model accuracy and runtime, thanks to some special properties of Bernstein polynomials. In summary, we solve the longstanding problem of multivariate stability and passivity enforcement in data-driven model order reduction, which insofar has been tackled only via either overconservative or heuristic and possibly unreliable methods

Convex Passivity Enforcement of Linear Macromodels via Alternate Subgradient Iterations

This paper introduces a new algorithm for passivity enforcement of linear lumped macromodels in scattering form. As typical in most state of the art passivity enforcement methods, we start with an initial non-passive macromodel obtained by a Vector Fitting process, and we perturb its parameters to make it passive. The proposed scheme is based on a convex formulation of both passivity constraints and objective function for accuracy preservation, thus allowing a formal proof of convergence to the unique optimal passive macromodel. This is a distinctive feature that differentiates the new scheme with respect to most state of the art methods, which either do not guarantee convergence or are not able to provide the most accurate solution. The presented algorithm can thus be safely used for those cases for which existing techniques fail. We illustrate the advantages of proposed method on a few benchmarks

Phenotypic and Molecular Selection of a Superior Solanum pennellii Introgression Sub-Line Suitable for Improving Quality Traits of Cultivated Tomatoes

The Solanum pennellii Introgression Line (IL) population can be exploited to identify favorable alleles that can improve yield and fruit quality traits in commercial tomato varieties. Over the past few years, we have selected ILs that exhibit increased content of antioxidant compounds in the fruit compared to the cultivar M82, which represents the genetic background in which the different wild regions of the S. pennellii ILs were included. Recently, we have identified seven sub-lines of the IL7-3 accumulating different amounts of antioxidants in the ripe fruit. Since the wild region carried on chromosome 7 induces a low fruit production in IL7-3, the first aim of the present work was to evaluate yield performances of the selected sub-lines in three experimental fields located in the South of Italy. Another aim was to confirm in the same lines the high levels of antioxidants and evaluate other fruit quality traits. On red ripe fruit, the levels of soluble solids content, firmness, and ascorbic acid (AsA) were highly variable among the sub-lines grown in three environmental conditions, evidencing a significant genotype by environment interaction for soluble solids and AsA content. Only one sub-line (coded R182) exhibited a significantly higher firmness, even though no differences were observed for this trait between the parental lines M82 and IL7-3. The same sub-line showed significantly higher AsA content compared to M82, thus resembling IL7-3. Even though IL7-3 always exhibited a significantly lower yield, all the sub-lines showed yield variability over the three trials. Interestingly, the sub-line R182, selected for its better performances in terms of fruit quality, in all the trials showed a production comparable to that of the control line M82. A group of species-specific molecular markers was tested on R182 and on the parental genotypes in order to better define the wild genomic regions carried by the elite line R182. In these regions three candidate genes that could increase the level of AsA in the fruit were identified. In the future, the line R182 could be used as pre-breeding material in order to obtain new varieties improved for nutritional traits

Towards a Hand Exoskeleton for a Smart EVA Glove

In this paper we investigate the key factors associated with the realization of a hand exoskeleton that could be embedded in an astronaut glove for EVA (Extra Vehicular Activities). Such a project poses several and varied problems, mainly due to the complex structure of the human hand and to the extreme environment in which the glove operates. This work provides an overview of existing exoskeletons and their related technologies and lays the ground for the forthcoming prototype realization, by presenting a preliminary analysis of possible solutions in terms of mechanical structure, actuators and sensors