157 research outputs found
Climate Change and Its Impact on Wheat Production in Kansas
This paper studies the effect of climate change on wheat production in Kansas using annual time series data from 1949 to 2014. For the study, an error correction model is developed in which the price of wheat, the price of oats (substitute good), average annual temperature and average annual precipitation are used as explanatory variables with total output of wheat being the dependent variable. Time series properties of the data series are diagnosed using unit root and cointegration tests. The estimated results suggest that Kansas farmers are supply responsive to both wheat as well as its substitute (oat) prices in the short run as well as in the long run. Climate variables; temperature has a positive effect on wheat output in the short run but an insignificant effect in the long run. Precipitation has a positive effect in the short run but a negative effect in the long run
Strained band edge characteristics from hybrid density functional theory and empirical pseudopotentials: GaAs, GaSb, InAs and InSb
The properties of a semiconductor are drastically modified when the crystal point group symmetry is broken under an arbitrary strain. We investigate the family of semiconductors consisting of GaAs, GaSb, InAs and InSb, considering their electronic band structure and deformation potentials subject to various strains based on hybrid density functional theory. Guided by these first-principles results, we develop strain-compliant local pseudopotentials for use in the empirical pseudopotential method (EPM). We demonstrate that the newly proposed empirical pseudopotentials perform well close to band edges and under anisotropic crystal deformations. Using the EPM, we explore the heavy hole-light hole mixing characteristics under different stress directions, which may be useful in manipulating their transport properties and optical selection rules. The very low 5 Ry cutoff targeted in the generated pseudopotentials paves the way for large-scale EPM-based electronic structure computations involving these lattice mismatched constituents. © 2016 IOP Publishing Ltd
Heterogeneous Delays in Neural Networks
We investigate heterogeneous coupling delays in complex networks of excitable
elements described by the FitzHugh-Nagumo model. The effects of discrete as
well as of uni- and bimodal continuous distributions are studied with a focus
on different topologies, i.e., regular, small-world, and random networks. In
the case of two discrete delay times resonance effects play a major role:
Depending on the ratio of the delay times, various characteristic spiking
scenarios, such as coherent or asynchronous spiking, arise. For continuous
delay distributions different dynamical patterns emerge depending on the width
of the distribution. For small distribution widths, we find highly synchronized
spiking, while for intermediate widths only spiking with low degree of
synchrony persists, which is associated with traveling disruptions, partial
amplitude death, or subnetwork synchronization, depending sensitively on the
network topology. If the inhomogeneity of the coupling delays becomes too
large, global amplitude death is induced
INCF/OCNS Software Working Group
Neuroscience cannot exist without its ecosystem of community-developed software tools that many of us rely heavily upon. The newly established Software Working Group, a community working group shared by the International Neuroinformatics Coordinating Facility (INCF) and the Organization for Computational Neurosciences (OCNS), aims to undertake activities that focus on these software tools. Members of the working group will find and discuss relevant software tools, learn and teach how to use them, test and review them, and report bugs to inform tool developers of issues when required. The working group will also strive to learn how these tools work to get involved in their development and maintenance. The aim is to ensure that the tools that our community depends on continue to be maintained by actively engaged community members, and to bring end users into close collaboration with tool developers. Since the working group includes many tool developers, it also serves as a platform to exchange design and development ideas, and will assist in improving interoperability between related tools. Another related goal of the working group is to help members define, improve, and teach transferable skills in the area of modern research software development, particularly in but not limited to, computational neuroscience. The working group is designed to be flexible, instead of being linked to a particular goal. This approach allows the group to pursue timely projects that its members value and are interested in working on. The current goals of the working group are: - To set up and maintain a living document of the current best practices in research software development to serve as a reference for the research community, especially tool developers - To host regular “developer sessions” where developer teams of various tools discuss their development pipelines (or workflows)—to disseminate various development practices, and help potential contributors get started. The activities of the working group can be followed on its website at https://ocns.github.io/SoftwareWG
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded future for European DILI research. This Roadmap aims to identify key challenges, define a shared vision across all stakeholders for the opportunities to overcome these challenges and propose a high-quality research program to achieve progress on the prediction, prevention, diagnosis and management of this condition and impact on healthcare practice in the field of DILI. This will involve 1. Creation of a database encompassing optimised case report form for prospectively identified DILI cases with well-characterised controls with competing diagnoses, biological samples, and imaging data; 2. Establishing of preclinical models to improve the assessment and prediction of hepatotoxicity in humans to guide future drug safety testing; 3. Emphasis on implementation science and 4. Enhanced collaboration between drug-developers, clinicians and regulatory scientists. This proposed operational framework will advance DILI research and may bring together basic, applied, translational and clinical research in DILI.Funding for open access charge: Universidad de Malaga/CBUA. The present study has been supported by grants from Instituto de Salud Carlos III (ISCIII) (contract numbers: PID2022–140169OB-C21; PI21/01248; PI19/00883) and from ConsejerĂa de Salud de AndalucĂa (contract number: PEMP-0127–2020, Spain), cofounded by the European Union. This research was funded by HORIZON-HLTH-2022-STAYHLTH-02, grant number 101095679. Funded by the European Union. Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them. MK was partially supported by Grant UID/BIM/0009/2020 of the Portuguese Fundação para a CiĂŞncia e a Tecnologia (FCT). MVP and IAA hold Sara Borrell research contracts from ISCIII (CD21/00198 and CD20/00083, respectively). This research was supported by CIBERehd – Consorcio Centro de InvestigaciĂłn BiomĂ©dica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Ministerio de Ciencia e InnovaciĂłn and UniĂłn Europea – European Regional Development Fund. JIG and GPA are supported by NIHR Nottingham Biomedical Research Centre [NIHR203310]. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health. This publication is based upon work from COST Action “CA17112—Prospective European Drug-Induced Liver Injury Network” supported by COST (European Cooperation in Science and Technology); www.cost.eu
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
\ua9 2024 The AuthorsIn the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, focused, and better funded future for European DILI research. This Roadmap aims to identify key challenges, define a shared vision across all stakeholders for the opportunities to overcome these challenges and propose a high-quality research program to achieve progress on the prediction, prevention, diagnosis and management of this condition and impact on healthcare practice in the field of DILI. This will involve 1. Creation of a database encompassing optimised case report form for prospectively identified DILI cases with well-characterised controls with competing diagnoses, biological samples, and imaging data; 2. Establishing of preclinical models to improve the assessment and prediction of hepatotoxicity in humans to guide future drug safety testing; 3. Emphasis on implementation science and 4. Enhanced collaboration between drug-developers, clinicians and regulatory scientists. This proposed operational framework will advance DILI research and may bring together basic, applied, translational and clinical research in DILI
Low dimensional nanostructures of fast ion conducting lithium nitride
As the only stable binary compound formed between an alkali metal and nitrogen, lithium nitride possesses remarkable properties and is a model material for energy applications involving the transport of lithium ions. Following a materials design principle drawn from broad structural analogies to hexagonal graphene and boron nitride, we demonstrate that such low dimensional structures can also be formed from an s-block element and nitrogen. Both one- and two-dimensional nanostructures of lithium nitride, Li3N, can be grown despite the absence of an equivalent van der Waals gap. Lithium-ion diffusion is enhanced compared to the bulk compound, yielding materials with exceptional ionic mobility. Li3N demonstrates the conceptual assembly of ionic inorganic nanostructures from monolayers without the requirement of a van der Waals gap. Computational studies reveal an electronic structure mediated by the number of Li-N layers, with a transition from a bulk narrow-bandgap semiconductor to a metal at the nanoscale
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A Scaleable and License Free 5G Internet of Radio Light Architecture for Services in Train Stations
In this paper we present a 5G Internet Radio-
Light (IoRL) architecture for underground train stations that
can be readily deployed because it utilizes unlicensed visible light
and millimeter wave part of the spectrum, which does not require
Mobile Network Operator (MNO) permission to deploy and
which is used to provide travelers with accurate location,
interaction, access to Internet and Cloud based Services, such as
high resolution video on a Tablet PC. The paper describes the
train station use cases and the IoRL architecture.European Commissio
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