A new method of measuring plastic limit of fine materials

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A New Look at Mode Conversion in a Stratified Isothermal Atmosphere

Recent numerical investigations of wave propagation near coronal magnetic null points (McLaughlin and Hood: Astron. Astrophys. 459, 641,2006) have indicated how a fast MHD wave partially converts into a slow MHD wave as the disturbance passes from a low-beta plasma to a high-beta plasma. This is a complex process and a clear understanding of the conversion mechanism requires the detailed investigation of a simpler model. An investigation of mode conversion in a stratified, isothermal atmosphere, with a uniform, vertical magnetic field is carried out, both numerically and analytically. In contrast to previous investigations of upward-propagating waves (Zhugzhda and Dzhalilov: Astron. Astrophys. 112, 16, 1982a; Cally: Astrophys. J. 548, 473, 2001), this paper studies the downward propagation of waves from a low-beta to high-beta environment. A simple expression for the amplitude of the transmitted wave is compared with the numerical solution.Comment: 14 pages, 6 figure

Tautness for riemannian foliations on non-compact manifolds

For a riemannian foliation $\mathcal{F}$ on a closed manifold $M$, it is known that $\mathcal{F}$ is taut (i.e. the leaves are minimal submanifolds) if and only if the (tautness) class defined by the mean curvature form $\kappa_\mu$ (relatively to a suitable riemannian metric $\mu$) is zero. In the transversally orientable case, tautness is equivalent to the non-vanishing of the top basic cohomology group $H^{^{n}}(M/\mathcal{F})$, where n = \codim \mathcal{F}. By the Poincar\'e Duality, this last condition is equivalent to the non-vanishing of the basic twisted cohomology group $H^{^{0}}_{_{\kappa_\mu}}(M/\mathcal{F})$, when $M$ is oriented. When $M$ is not compact, the tautness class is not even defined in general. In this work, we recover the previous study and results for a particular case of riemannian foliations on non compact manifolds: the regular part of a singular riemannian foliation on a compact manifold (CERF).Comment: 18 page

3D MHD Coronal Oscillations About a Magnetic Null Point: Application of WKB Theory

This paper is a demonstration of how the WKB approximation can be used to help solve the linearised 3D MHD equations. Using Charpit's Method and a Runge-Kutta numerical scheme, we have demonstrated this technique for a potential 3D magnetic null point, ${\bf{B}}=(x,\epsilon y -(\epsilon +1)z)$. Under our cold plasma assumption, we have considered two types of wave propagation: fast magnetoacoustic and Alfv\'en waves. We find that the fast magnetoacoustic wave experiences refraction towards the magnetic null point, and that the effect of this refraction depends upon the Alfv\'en speed profile. The wave, and thus the wave energy, accumulates at the null point. We have found that current build up is exponential and the exponent is dependent upon $\epsilon$. Thus, for the fast wave there is preferential heating at the null point. For the Alfv\'en wave, we find that the wave propagates along the fieldlines. For an Alfv\'en wave generated along the fan-plane, the wave accumulates along the spine. For an Alfv\'en wave generated across the spine, the value of $\epsilon$ determines where the wave accumulation will occur: fan-plane ($\epsilon=1$), along the $x-$axis ($0<\epsilon <1$) or along the $y-$axis ($\epsilon>1$). We have shown analytically that currents build up exponentially, leading to preferential heating in these areas. The work described here highlights the importance of understanding the magnetic topology of the coronal magnetic field for the location of wave heating.Comment: 26 pages, 12 figure

Review article: MHD wave propagation near coronal null points of magnetic fields

We present a comprehensive review of MHD wave behaviour in the neighbourhood of coronal null points: locations where the magnetic field, and hence the local Alfven speed, is zero. The behaviour of all three MHD wave modes, i.e. the Alfven wave and the fast and slow magnetoacoustic waves, has been investigated in the neighbourhood of 2D, 2.5D and (to a certain extent) 3D magnetic null points, for a variety of assumptions, configurations and geometries. In general, it is found that the fast magnetoacoustic wave behaviour is dictated by the Alfven-speed profile. In a $\beta=0$ plasma, the fast wave is focused towards the null point by a refraction effect and all the wave energy, and thus current density, accumulates close to the null point. Thus, null points will be locations for preferential heating by fast waves. Independently, the Alfven wave is found to propagate along magnetic fieldlines and is confined to the fieldlines it is generated on. As the wave approaches the null point, it spreads out due to the diverging fieldlines. Eventually, the Alfven wave accumulates along the separatrices (in 2D) or along the spine or fan-plane (in 3D). Hence, Alfven wave energy will be preferentially dissipated at these locations. It is clear that the magnetic field plays a fundamental role in the propagation and properties of MHD waves in the neighbourhood of coronal null points. This topic is a fundamental plasma process and results so far have also lead to critical insights into reconnection, mode-coupling, quasi-periodic pulsations and phase-mixing.Comment: 34 pages, 5 figures, invited review in Space Science Reviews => Note this is a 2011 paper, not a 2010 pape

Model confidence sets and forecast combination: an application to age-specific mortality

Background: Model averaging combines forecasts obtained from a range of models, and it often produces more accurate forecasts than a forecast from a single model. Objective: The crucial part of forecast accuracy improvement in using the model averaging lies in the determination of optimal weights from a finite sample. If the weights are selected sub-optimally, this can affect the accuracy of the model-averaged forecasts. Instead of choosing the optimal weights, we consider trimming a set of models before equally averaging forecasts from the selected superior models. Motivated by Hansen et al. (2011), we apply and evaluate the model confidence set procedure when combining mortality forecasts. Data & Methods: The proposed model averaging procedure is motivated by Samuels and Sekkel (2017) based on the concept of model confidence sets as proposed by Hansen et al. (2011) that incorporates the statistical significance of the forecasting performance. As the model confidence level increases, the set of superior models generally decreases. The proposed model averaging procedure is demonstrated via national and sub-national Japanese mortality for retirement ages between 60 and 100+. Results: Illustrated by national and sub-national Japanese mortality for ages between 60 and 100+, the proposed model-average procedure gives the smallest interval forecast errors, especially for males. Conclusion: We find that robust out-of-sample point and interval forecasts may be obtained from the trimming method. By robust, we mean robustness against model misspecification

Coronary artery disease, left ventricular hypertrophy and diastolic dysfunction are associated with stroke in patients affected by persistent non-valvular atrial fibrillation: a case-control study

Persistent non-valvular atrial fibrillation (NVAF) is associated with an increased risk of cardiovascular events such as stroke, and its rate is expected to rise because of the ageing population. The absolute rate of stroke depends on age and comorbidity. Risk stratification for stroke in patients with NVAF derives from populations enrolled in randomized clinical trials. However, participants in clinical trials are often not representative of the general population. Many stroke risk stratification scores have been used, but they do not include transthoracic echocardiogram (TTE), pulsate wave Doppler (PWD) and tissue Doppler imaging (TDI), simple and non- invasive diagnostic tools. The role of TTE, PWD and TDI findings has not been previously determined. Our study goal was to determine the association between TTE and PWD findings and stroke prevalence in a population of NVAF prone outpatients

Patient-reported outcome results from the open-label, randomized phase III myeloma X trial evaluating salvage autologous stem-cell transplantation in relapsed multiple myeloma

Purpose: Salvage autologous stem-cell transplantation (sASCT) in patients with multiple myeloma (MM) relapsing after a prior autologous stem-cell transplantation leads to increased remission duration and overall survival. We report a comprehensive study on patient-reported outcomes, including quality of life (QoL) and pain in sASCT. Methods: Patients were randomly assigned to either sASCT or nontransplantation consolidation (NTC). Pain and QoL were assessed as secondary outcomes using validated QoL instruments (European Organisation for Research and Treatment of Cancer QLQ-C30 and myeloma-specific module, QLQ-MY20; the Brief Pain Inventory [Short Form]; and the Leeds Assessment of Neuropathic Symptoms and Signs [Self-Assessment] scale). Results: A total of 288 patients (> 96%) consented to the QoL substudy. The median follow-up was 52 months. The European Organisation for Research and Treatment of Cancer QLQ-C30 Global health status scores were higher (better) in the NTC group at 100 days after random assignment ( P = .0496), but not at later time points. Pain interference was higher (worse) in the sASCT group than in the NTC group at 6 months after random assignment ( P = .0267), with patients with sASCT reporting higher scores for Pain interference with daily living for up to 2 years after random assignment. Patients reporting lower concerns about adverse effects of treatment after sASCT had a time to progression advantage. Conclusion: Patients with sASCT with relapsed MM demonstrated a comparative reduction in QoL and greater impact of treatment adverse effects lasting for 6 months and up to 2 years for pain, after which patients who had received sASCT reported better outcomes. Patients who experienced lower adverse effects after sASCT had longer time to progression and overall survival, showing the need to improve symptom management peritransplantation. To our knowledge, this study provides the most comprehensive picture of QoL before and after sASCT in patients with relapsed MM

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele