Clinician miscalibration of survival estimate in hypothermic cardiac arrest: HOPE-estimated survival probabilities in extreme cases.

Patients with hypothermic cardiac arrest may survive with an excellent outcome after extracorporeal life support rewarming (ECLSR). The HOPE (Hypothermia Outcome Prediction after ECLS) score is recommended to guide the in-hospital decision on whether or not to initiate ECLSR in patients in cardiac arrest following accidental hypothermia. We aimed to assess the HOPE-estimated survival probabilities for a set of survivors of hypothermic cardiac arrest who had extreme values for the variables included in the HOPE score. Survivors were identified and selected through a systematic literature review including case reports. We calculated the HOPE score for each patient who presented extraordinary clinical parameters. We identified 12 such survivors. The HOPE-estimated survival probability was ≥10% for all (n = 11) patients for whom we were able to calculate the HOPE score. Our study confirms the robustness of the HOPE score for outliers and thus further confirms its external validity. These cases also confirm that hypothermic cardiac arrest is a fundamentally different entity than normothermic cardiac arrest. Using HOPE for extreme cases may support the proper calibration of a clinician's prognosis and therapeutic decision based on the survival chances of patients with accidental hypothermic cardiac arrest

Capillary Electrophoresis Separation of Protein Composition of γ-Irradiated Food Pathogens Listeria monocytogenes and Staphylococcus aureus

which were previously treated at different irradiation doses., one protein (50 S ribosomal protein) with the MW of 16.3 kDa was significantly decreased at a low dose of irradiation treatment and the other protein (transcriptional regulator CtsR) with the MW of 17.7 kDa was increased significantly (P≤0.05) at all doses of irradiation treatment compared to control.. The research further confirmed that capillary electrophoresis is a useful method to separate and analyse proteins expression which may be related to the resistance or sensitivity of food pathogens to γ-irradiation

2020 State of Open at the University of Colorado Boulder: An Update on Open Access Practices Based on Data from 2019

Using data from 2019, this report is the second annual update to the &ldquo;State of Open at the University of Colorado Boulder: A Baseline Analysis of Open Access Practices from 2012 to 2018&rdquo;: ​https://doi.org/10.25810/vprn-v113​. It includes analyses of open access (OA) journal publishing, OA repository usage, and open data practices by researchers at the University of Colorado Boulder (CU Boulder). Data used to produce this report can be found here: ​https://doi.org/10.25810/p5fa-y621​. Key findings from this report include: 9.95% of all articles published in 2019 by CU Boulder authors were published in full OA journals, which is up slightly from 9.63% in 2018; In 2019, the CU Boulder Libraries OA Fund funded author fees totalling $100,588.42 for 65 journal articles published by CU Boulder authors in full OA journals (up from$91,041.36 for 57 articles in 2018); As of January 2020, there were 11,426 OA items in the CU Scholar institutional repository (up from 10,638 at the time of the previous report), and these items were downloaded a total of 760,400 times in 2019 (up from 625,325 in 2018); In the annual Faculty Report of Professional Activities (FRPA), faculty reported 65 published data sets in 2019 (up from 56 in 2018) with 44 of these citations including Digital Object Identifiers (DOIs) (up from 34 in 2018) and 56 identifying a formal data repository (reported for the first time in this report); The Libraries and its partners registered 197 DataCite DOIs for published data sets in 2019 (up from 112 in 2018). </div

The amino acid and hydrocarbon contents of the Paris meteorite: Insights into the most primitive CM chondrite

International audienc

Aluminum-, Calcium- And Titanium-Rich Oxide Stardust In Ordinary Chondrite Meteorites

We report isotopic data for a total of 96 presolar oxide grains found in residues of several unequilibrated ordinary chondrite meteorites. Identified grain types include Al2O3, MgAl2O4, hibonite (CaAl12O19) and Ti oxide. This work greatly increases the presolar hibonite database, and is the first report of presolar Ti oxide. O-isotopic compositions of the grains span previously observed ranges and indicate an origin in red giant and asymptotic giant branch (AGB) stars of low mass (<2.5 MSun) for most grains. Cool bottom processing in the parent AGB stars is required to explain isotopic compositions of many grains. Potassium-41 enrichments in hibonite grains are attributable to in situ decay of now-extinct 41Ca. Inferred initial 41Ca/40Ca ratios are in good agreement with model predictions for low-mass AGB star envelopes, provided that ionization suppresses 41Ca decay. Stable Mg and Ca isotopic ratios of most of the hibonite grains reflect primarily the initial compositions of the parent stars and are generally consistent with expectations for Galactic chemical evolution, but require some local interstellar chemical inhomogeneity. Very high 17O/16O or 25Mg/24Mg ratios suggest an origin for some grains in binary star systems where mass transfer from an evolved companion has altered the parent star compositions. A supernova origin for the hitherto enigmatic 18O-rich Group 4 grains is strongly supported by multi-element isotopic data for two grains. The Group 4 data are consistent with an origin in a single supernova in which variable amounts of material from the deep 16O-rich interior mixed with a unique end-member mixture of the outer layers. The Ti oxide grains primarily formed in low-mass AGB stars. They are smaller and rarer than presolar Al2O3, reflecting the lower abundance of Ti than Al in AGB envelopes.Comment: Accepted for publication in ApJ; 47 pages, 13 figure

2022 State of Open at the University of Colorado Boulder: An Update on Open Access Practices Based on Data from 2021

Using data from 2021, this report is the fourth annual update to the &ldquo;State of Open at the University of Colorado Boulder: A Baseline Analysis of Open Access Practices from 2012 to 2018&rdquo;: https://doi.org/10.25810/vprn-v113. It includes analyses of open access (OA) article publishing activities, OA repository usage, and data publishing practices by researchers at the University of Colorado Boulder (CU Boulder). Data used to produce this report can be found here: https://doi.org/10.25810/tt4b-9v88 Key findings from this report include: 62% of articles published in 2021 by CU Boulder authors are available via some type of OA (Gold, Green, Hybrid, or Bronze) (up from 60% at the time of the 2020 report); In 2021, the CU Boulder Libraries OA Fund funded author fees totaling $89,761 for 53 journal articles published by CU Boulder authors in full OA journals (up from$57,769 for 34 journal articles in 2020); At the end of 2021, there were 13,791 OA items in the CU Scholar institutional repository (up from 11,810 in 2020), and these items were downloaded a total of 39,393 times in 2021 (down from 43,236 in 2020); In the annual Faculty Report of Professional Activities (FRPA), faculty reported 92 published data sets in 2021 (up from 65 in 2020) with 76 of these citations including Digital Object Identifiers (DOIs) (up from 50 in 2020) and 68 citations identifying a formal data repository (up from 54 in 2020); The Libraries and its partners registered 416 DataCite DOIs for published data sets in 2021 (up from 320 in 2020).</p

2023 State of Open at the University of Colorado Boulder: An Update on Open Access Practices Based on Data from 2022

Using data from 2022, this report is the fifth annual update to the &ldquo;State of Open at the University of Colorado Boulder: A Baseline Analysis of Open Access Practices from 2012 to 2018&rdquo;: https://doi.org/10.25810/vprn-v113. It includes analyses of open access (OA) article publishing activities, OA repository usage, and data publishing practices by researchers at the University of Colorado Boulder (CU Boulder). Data used to produce this report can be found here:&nbsp;https://doi.org/10.25810/ktb4-ce48 &nbsp; Key findings from this report include: &nbsp; 72% of articles published in 2022 by CU Boulder authors are available via some type of OA (Gold, Green, Hybrid, or Bronze) (up from 62% at the time of the 2021 report); &nbsp; In 2022, the CU Boulder Libraries OA Fund funded author fees totaling $69,804 for 41 journal articles published by CU Boulder authors in full OA journals (down from$89,761 for 53 journal articles in 2021); however, these decreases have more to do with the OA Fund being exhausted earlier in the fiscal year than an actual decrease in funding; &nbsp; At the end of 2022, there were 16,090 OA items in the CU Scholar institutional repository (up from 13,791 in 2021), and these items were downloaded a total of 36,730 times in 2022 (down from 39,393 in 2021); &nbsp; In the annual Faculty Report of Professional Activities (FRPA), faculty reported 56 published data sets in 2022 (down from 92 in 2021) with 87.5% of these citations including Digital Object Identifiers (DOIs) (up from 82.6% in 2021) and 95% of these citations identifying a formal data repository (same as 95% in 2021); &nbsp; The Libraries and its partners registered 335 DataCite DOIs for published data sets in 2022 (down from 416 in 2021); &nbsp; This is the first year there has been a decrease in either the number of reported published data sets in FRPA or the number of DataCite DOIs registered for published data sets, so it will be important to monitor these numbers in the coming years to see if this is an anomaly or the start of a new trend.</p

Perceived Hospital Preparedness Is Negatively Associated With Pandemic-Induced Psychological Vulnerability in Primary Care Employees: A Multicentre Cross-Sectional Observational Study.

The COVID-19 pandemic had a profound negative impact on the psychological wellbeing of healthcare providers (HPs), but little is known about the factors that positively predict mental health of primary care staff during these dire situations. We conducted an online questionnaire survey among 702 emergency department workers across 10 hospitals in Switzerland and Belgium following the first COVID-19 wave in 2020, to explore their psychological vulnerability, perceived concerns, self-reported impact and level of pandemic workplace preparedness. Participants included physicians, nurses, psychologists and nondirect care employees (administrative staff). We tested for predictors of psychological vulnerability through both an exploratory cross-correlation with rigorous correction for multiple comparisons and model-based path modelling. Findings showed that the self-reported impact of COVID-19 at work, concerns about contracting COVID-19 at work, and a lack of personal protective equipment were strong positive predictors of Depression, Anxiety, and Stress, and low Resilience. Instead, knowledge of the degree of preparedness of the hospital/department, especially in the presence of a predetermined contingency plan for an epidemic and training sessions about protective measures, showed the opposite effect, and were associated with lower psychological vulnerability. All effects were confirmed after accounting for confounding factors related to gender, age, geographical location and the role played by HPs in the hospital/department. Difficult working conditions during the pandemic had a major impact on the psychological wellbeing of emergency department HPs, but this effect might have been lessened if they had been informed about adequate measures for minimizing the risk of exposure