Modeling the angular correlation function and its full covariance in Photometric Galaxy Surveys

Near future cosmology will see the advent of wide area photometric galaxy surveys, like the Dark Energy Survey (DES), that extent to high redshifts (z ~ 1 - 2) but with poor radial distance resolution. In such cases splitting the data into redshift bins and using the angular correlation function $w(\theta)$, or the $C_{\ell}$ power spectrum, will become the standard approach to extract cosmological information or to study the nature of dark energy through the Baryon Acoustic Oscillations (BAO) probe. In this work we present a detailed model for $w(\theta)$ at large scales as a function of redshift and bin width, including all relevant effects, namely nonlinear gravitational clustering, bias, redshift space distortions and photo-z uncertainties. We also present a model for the full covariance matrix characterizing the angular correlation measurements, that takes into account the same effects as for $w(\theta)$ and also the possibility of a shot-noise component and partial sky coverage. Provided with a large volume N-body simulation from the MICE collaboration we built several ensembles of mock redshift bins with a sky coverage and depth typical of forthcoming photometric surveys. The model for the angular correlation and the one for the covariance matrix agree remarkably well with the mock measurements in all configurations. The prospects for a full shape analysis of $w(\theta)$ at BAO scales in forthcoming photometric surveys such as DES are thus very encouraging.Comment: 23 pages, 21 figures Revised version accepted by MNRAS. Description of mocks re-structured. Mocks including redshift distortions and Photo-z publicly available at http://www.ice.cat/mic

Deficient endoplasmic reticulum-mitochondrial phosphatidylserine transfer causes liver disease

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with nonalcoholic steatohepatitis (NASH). Moreover, reduced Mfn2 levels were detected in mouse models of steatosis or NASH, and its re-expression in a NASH mouse model ameliorated the disease. Liver-specific ablation of Mfn2 in mice provoked inflammation, triglyceride accumulation, fibrosis, and liver cancer. We demonstrate that Mfn2 binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrial phosphatidylethanolamine (PE) synthesis. Consequently, hepatic Mfn2 deficiency reduces PS transfer and phospholipid synthesis, leading to endoplasmic reticulum (ER) stress and the development of a NASH-like phenotype and liver cancer. Ablation of Mfn2 in liver reveals that disruption of ER-mitochondrial PS transfer is a new mechanism involved in the development of liver disease

La stimulation magnétique trans-crânienne répétitive à basse fréquence (rTMS) au niveau de l'hémisphère gauche est-elle efficace pour la rééducation de la négligence spatiale unilatérale persistante après un AVC ?

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Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users

Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations

Plasma Energy-Balance Metabolites Discriminate Asymptomatic Patients with Peripheral Artery Disease

Peripheral artery disease (PAD) is a common disease affecting 20–25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated with other highly prevalent and related conditions, such as diabetes, dyslipidemia, and hypertension. We have measured energy-balance-associated metabolite concentrations in the plasma of PAD patients segregated by the severity of the disease and in plasma of healthy volunteers using a quantitative and targeted metabolomic approach. We found relevant associations between several metabolites (3-hydroxybutirate, aconitate, (iso)citrate, glutamate, and serine) with markers of oxidative stress and inflammation. Metabolomic profiling also revealed that (iso)citrate and glutamate are metabolites with high ability to discriminate between healthy participants and PAD patients without symptoms. Collectively, our data suggest that metabolomics provide significant information on the pathogenesis of PAD and useful biomarkers for the diagnosis and assessment of progression